Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects
CONCLUSION: The PD parameters of esomeprazole 10 mg were comparable to those of famotidine after multiple doses. These findings provide support for further evaluating the use of 10 mg of esomeprazole as a treatment option for gastritis.PMID:37382329 | DOI:10.5414/CP204391 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Ha-Yeon Kim Jun Gi Hwang Jae-Won Kim Chang Hwan Seong Ji Hyeon Lee Hyung Son Kim Hye Yun Kim Yu Kyong Kim Min Kyu Park Source Type: research
Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
In conclusion, in light of the results that we obtained, 50 mg/kg taxifolin was revealed to have anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.PMID:37331803 | DOI:10.1538/expanim.22-0065 (Source: Experimental Animals)
Source: Experimental Animals - June 18, 2023 Category: Research Authors: Serkan Cerrah Nergiz Akbas Fatih Özcicek Renad Mammadov Durdu Altuner Halis S üleyman Seval Bulut Source Type: research
Effect of felodipine on indomethacin-induced gastric ulcers in rats
Exp Anim. 2023 Jun 13. doi: 10.1538/expanim.23-0052. Online ahead of print.ABSTRACTFelodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically i...
Source: Experimental Animals - June 14, 2023 Category: Research Authors: Nergis Akba ş Bahad ır Süleyman Renad Mammadov Mine G ülaboğlu Emin Murat Akba ş Halis S üleyman Source Type: research
Evaluation of the Efficacy and Safety of DW1903 in Patients with Gastritis: A Randomized, Double-Blind, Noninferiority, Multicenter, Phase 3 study
CONCLUSIONS: DW1903 of a low-dose PPI was not inferior to DW1903R1 of H2RA. Thus, lowdose PPI can be a novel option for treating gastritis (ClinicalTrials.gov Identifier: NCT05163756).PMID:37309193 | DOI:10.5009/gnl220446 (Source: Gut and Liver)
Source: Gut and Liver - June 13, 2023 Category: Gastroenterology Authors: Jie-Hyun Kim Hwoon-Yong Jung In Kyung Yoo Seon-Young Park Jae Gyu Kim Jae Kyu Sung Jin Seok Jang Gab Jin Cheon Kyoung Oh Kim Tae Oh Kim Soo Teik Lee Kwang Bum Cho Hoon Jai Chun Jong-Jae Park Moo In Park Jae-Young Jang Seong Woo Jeon Jin Woong Cho Dae Hwan Source Type: research
