Inhibition of Aspirin-Induced Gastrointestinal Injury: Systematic Review and Network Meta-Analysis
Conclusion: This is the first systematic review and network meta-analysis of different treatments for aspirin-induced gastrointestinal injury. Our study suggested that omeprazole plus rebamipide might be considered the best option to treat aspirin-induced gastrointestinal injury. More multicenter, high quality, large sample size randomized controlled trials will confirm the advantages of these medicines in the treatment of aspirin-induced gastrointestinal injury in the future. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 12, 2021 Category: Drugs & Pharmacology Source Type: research

A Birds-Eye (Re)View of Acid-Suppression Drugs, COVID-19, and the Highly Variable Literature
This Perspective examines a recent surge of information regarding the potential benefits of acid-suppression drugs in the context of COVID-19, with a particular eye on the great variability (and, thus, confusion) that has arisen across the reported findings, at least as regards the popular antacid famotidine. The degree of inconsistency and discordance reflects contradictory conclusions from independent, clinical-based studies that took roughly similar approaches, in terms of both experimental design (retrospective, observational, cohort-based, etc.) and statistical analysis workflows (propensity-score matching and stratif...
Source: Frontiers in Pharmacology - August 11, 2021 Category: Drugs & Pharmacology Source Type: research

Hereditary angioedema
AbstractA 14-year-old African American female presented to the emergency department with spontaneous, sudden-onset lip swelling for 1 h. On examination, there was significant water-bag edema of the upper lip extending to the philtrum and premaxilla. Nasopharyngeal laryngoscopy revealed a patent airway without edema. She was initiated on intravenous dexamethasone, famotidine, and diphenhydramine, after which her edema improved but did not resolve. She was subsequently transferred to a local pediatric hospital and upon further testing she was found to have a C1 esterase inhibitor de novo gene mutation. Angioedema causes loca...
Source: International Journal of Emergency Medicine - July 29, 2021 Category: Emergency Medicine Source Type: research

Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro
AbstractProton pump inhibitors (PPIs) have been associated with an increased risk of fragility fractures in pharmaco-epidemiological studies. The mechanism is unclear, but it has been speculated that by neutralising gastric acid, they may reduce intestinal calcium absorption, causing secondary hyperparathyroidism and bone loss. Here we investigated that hypothesis that the skeletal effects of PPI might be mediated by inhibitory effects on the bone-specific phosphatase PHOSPHO1. We found that the all PPIs tested inhibited the activity of PHOSPHO1 with IC50 ranging between 0.73  µM for esomeprazole to 19.27 µM for pantop...
Source: Calcified Tissue International - July 2, 2021 Category: Orthopaedics Source Type: research

[ASAP] Polymorphic Solubility Ratio of Famotidine and Sulfathiazole in Various Solvents
Crystal Growth& DesignDOI: 10.1021/acs.cgd.1c00064 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - April 23, 2021 Category: Chemistry Authors: Yoshihiro Takebayashi, Kiwamu Sue, Takeshi Furuya, and Satoshi Yoda Source Type: research

Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial
This study indicated that curcumin therapy could be a favorable supplementation in the symptom management of functional dyspepsia. Moreover, curcumin could help efficient eradication of H. pylori in these patients.PMID:33861441 | DOI:10.1007/978-3-030-64872-5_10 (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - April 16, 2021 Category: Research Authors: Yunes Panahi Ashraf Karbasi Ghasem Valizadegan Nayyereh Ostadzadeh Sara Saffar Soflaei Tannaz Jamialahmadi Muhammed Majeed Amirhossein Sahebkar Source Type: research

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19
Comput Biol Chem. 2021 Apr 5;92:107482. doi: 10.1016/j.compbiolchem.2021.107482. Online ahead of print.ABSTRACTComplement system plays a dual role; physiological as well as pathophysiological. While physiological role protects the host, pathophysiological role can substantially harm the host, by triggering several hyper-inflammatory pathways, referred as "hypercytokinaemia". Emerging clinical evidence suggests that exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), tricks the complement to aberrantly activate the "hypercytokinaemia" loop, which significantly contributes to the severity of the COVID19....
Source: Computational Biology and Chemistry - April 12, 2021 Category: Bioinformatics Authors: Aurosikha Das Soumendra Rana Source Type: research

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19
Comput Biol Chem. 2021 Apr 5;92:107482. doi: 10.1016/j.compbiolchem.2021.107482. Online ahead of print.ABSTRACTComplement system plays a dual role; physiological as well as pathophysiological. While physiological role protects the host, pathophysiological role can substantially harm the host, by triggering several hyper-inflammatory pathways, referred as "hypercytokinaemia". Emerging clinical evidence suggests that exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), tricks the complement to aberrantly activate the "hypercytokinaemia" loop, which significantly contributes to the severity of the COVID19....
Source: Computational Biology and Chemistry - April 12, 2021 Category: Bioinformatics Authors: Aurosikha Das Soumendra Rana Source Type: research

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19
Comput Biol Chem. 2021 Apr 5;92:107482. doi: 10.1016/j.compbiolchem.2021.107482. Online ahead of print.ABSTRACTComplement system plays a dual role; physiological as well as pathophysiological. While physiological role protects the host, pathophysiological role can substantially harm the host, by triggering several hyper-inflammatory pathways, referred as "hypercytokinaemia". Emerging clinical evidence suggests that exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), tricks the complement to aberrantly activate the "hypercytokinaemia" loop, which significantly contributes to the severity of the COVID19....
Source: Computational Biology and Chemistry - April 12, 2021 Category: Bioinformatics Authors: Aurosikha Das Soumendra Rana Source Type: research