Impact of histamine-2 antagonist shortage on the incidence of hypersensitivity reactions to paclitaxel: a reconsideration of premedication protocols in France (PACLIREACT Study)
ConclusionWe did not find substantial evidence of an increased risk of HSR due to the absence of H2A in the premedication protocols for paclitaxel. Thus, in contrary to the existing literature on paclitaxel, our findings support the use of a premedication protocol without H2A. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - July 13, 2023 Category: Drugs & Pharmacology Source Type: research

Alectinib-induced Hemolytic Anemia with Positive Direct Antiglobulin Test in a Patient with Lung Adenocarcinoma: A Possible Drug-Drug Interaction Effect
Intern Med. 2023 Jul 12. doi: 10.2169/internalmedicine.1286-22. Online ahead of print.ABSTRACTRecent studies have reported that direct antiglobulin test (DAT) results were negative in cases of alectinib-induced hemolytic anemia with abnormal red blood cell (RBC) morphology. We herein report the case of a 72-year-old female patient who was diagnosed with alectinib-induced hemolytic anemia who-in contrast to previous reports-showed a positive DAT result. After discontinuing famotidine and alectinib, the DAT results turned negative; however, when alectinib was resumed, hemolysis recurred. Although alectinib-induced hemolytic ...
Source: Internal Medicine - July 12, 2023 Category: Internal Medicine Authors: Yuta Isomura Hiroyuki Tamiya Source Type: research

Famotidine: A potential mitigator of mast cell activation in post-COVID-19 cognitive impairment
J Psychosom Res. 2023 Jun 26;172:111425. doi: 10.1016/j.jpsychores.2023.111425. Online ahead of print.NO ABSTRACTPMID:37399740 | DOI:10.1016/j.jpsychores.2023.111425 (Source: Cell Research)
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Chia Siang Kow Dinesh Sangarran Ramachandram Syed Shahzad Hasan Source Type: research

Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects
CONCLUSION: The PD parameters of esomeprazole 10 mg were comparable to those of famotidine after multiple doses. These findings provide support for further evaluating the use of 10 mg of esomeprazole as a treatment option for gastritis.PMID:37382329 | DOI:10.5414/CP204391 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Ha-Yeon Kim Jun Gi Hwang Jae-Won Kim Chang Hwan Seong Ji Hyeon Lee Hyung Son Kim Hye Yun Kim Yu Kyong Kim Min Kyu Park Source Type: research

Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects
CONCLUSION: The PD parameters of esomeprazole 10 mg were comparable to those of famotidine after multiple doses. These findings provide support for further evaluating the use of 10 mg of esomeprazole as a treatment option for gastritis.PMID:37382329 | DOI:10.5414/CP204391 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Ha-Yeon Kim Jun Gi Hwang Jae-Won Kim Chang Hwan Seong Ji Hyeon Lee Hyung Son Kim Hye Yun Kim Yu Kyong Kim Min Kyu Park Source Type: research

Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects
CONCLUSION: The PD parameters of esomeprazole 10 mg were comparable to those of famotidine after multiple doses. These findings provide support for further evaluating the use of 10 mg of esomeprazole as a treatment option for gastritis.PMID:37382329 | DOI:10.5414/CP204391 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Ha-Yeon Kim Jun Gi Hwang Jae-Won Kim Chang Hwan Seong Ji Hyeon Lee Hyung Son Kim Hye Yun Kim Yu Kyong Kim Min Kyu Park Source Type: research

Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects
CONCLUSION: The PD parameters of esomeprazole 10 mg were comparable to those of famotidine after multiple doses. These findings provide support for further evaluating the use of 10 mg of esomeprazole as a treatment option for gastritis.PMID:37382329 | DOI:10.5414/CP204391 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Ha-Yeon Kim Jun Gi Hwang Jae-Won Kim Chang Hwan Seong Ji Hyeon Lee Hyung Son Kim Hye Yun Kim Yu Kyong Kim Min Kyu Park Source Type: research