Evaluation of the Effects of Meal Type and Acid ‐Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist
This study suggests that caution should be exercised when cilofexor is administered with ARAs under fed conditions; coadministration of cilofexor (100 or 30  mg) with ARAs under fasting conditions is not recommended with the current clinical trial formulations. (Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - February 13, 2024 Category: Drugs & Pharmacology Authors: Elijah J. Weber, Islam R. Younis, Lulu Wang, Deqing Xiao, William T. Barchuk, Ahmed A. Othman Tags: Original Article Source Type: research

Tenecteplase-associated orolingual angioedema: A case report and literature review
CONCLUSION: Although rare, OA is a potentially life-threatening complication of tenecteplase therapy and requires prompt pharmacological intervention to optimize patient outcomes. Currently, no single agent or treatment algorithm exists that has shown significant efficacy or safety in the setting of thrombolytic-associated OA. Until data are available for C1 esterase inhibitors in this application, these inhibitors should only be considered if there is continued symptom progression after intravenous administration of corticosteroids and antihistamines.PMID:38270186 | DOI:10.1093/ajhp/zxad334 (Source: American Journal of He...
Source: American Journal of Health-System Pharmacy : AJHP - January 25, 2024 Category: Drugs & Pharmacology Authors: Jeffrey K Pitts Dylan M Burns Kevin R Patellos Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Fabrication of pellets via extrusion-spheronisation for engineered delivery of Famotidine through specialized straws for Paediatrics
CONCLUSION: Finally, the fast-disintegrating pellets demonstrated excellent in vitro performance and relative ease of manufacturing as compared to other solid dosage forms. Furthermore, the developed specialized straw can be used as a convenient and attractive drug delivery device for pediatrics.PMID:38135035 | DOI:10.1016/j.pharma.2023.12.008 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - December 22, 2023 Category: Drugs & Pharmacology Authors: Shweta Purandare Shubham Khot Amelia Avachat Source Type: research

Evaluation of outpatient prescription patterns of COVID-19 drugs in Iran: comparison of real practice with local therapeutic recommendations
ConclusionIn this study, we showed frequent use of drugs with unproven efficacy in outpatient cases of Covid-19 mostly attributed to corticosteroids and antibiotics use. Our research highlights the discrepancy between recommendations for care and clinical practice and the need for strategy to bridge gaps in evidence-based informed decision-making. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - November 27, 2023 Category: Pharmaceuticals Source Type: research

pH-Sensitive Adsorption of Gastrointestinal Drugs (Famotidine and Pantoprazole) as pharmaceutical pollutants by Au-Doped@ZIF-90-Glycerol Adsorbent: Insights from Computational Modeling
J. Mater. Chem. A, 2023, Accepted Manuscript DOI: 10.1039/D3TA05221D, PaperNarjes Montazeri, Iman Salahshoori , Parivash Feyzishendi, Fatemeh Sadat Miri, Mehdi Moayed Mohseni, Hossein Ali Khonakdar Pharmaceutical pollutants, such as gastrointestinal drugs, pose a significant environmental concern due to their widespread use and potential adverse effects on ecosystems. Insights obtained from computational simulations yielded a more... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - November 9, 2023 Category: Chemistry Authors: Narjes Montazeri Source Type: research

Ranitidine Use and Incident Cancer in a Multinational Cohort
CONCLUSIONS AND RELEVANCE: In this cohort study, ranitidine use was not associated with an increased risk of cancer compared with the use of other H2RAs. Further research is needed on the long-term association of ranitidine with cancer development.PMID:37725377 | DOI:10.1001/jamanetworkopen.2023.33495 (Source: Cancer Control)
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Seng Chan You Seung In Seo Thomas Falconer Chen Yanover Talita Duarte-Salles Sarah Seager Jose D Posada Nigam H Shah Phung-Anh Nguyen Yeesuk Kim Jason C Hsu Mui Van Zandt Min-Huei Hsu Hang Lak Lee Heejoo Ko Woon Geon Shin Nicole Pratt Rae Woong Park Chris Source Type: research

A Case Report of Venezuelan Suntiger Tarantula (Psalmopoeus Irminia) Envenomation and Review of Tarantula Exposures
J Emerg Med. 2023 Jun 10:S0736-4679(23)00320-7. doi: 10.1016/j.jemermed.2023.05.022. Online ahead of print.ABSTRACTBACKGROUND: Tarantula envenomations are encountered infrequently but may increase with increased exotic animal ownership. This case report presents the first documented toxicity from a Venezuelan suntiger tarantula (VST), Psalmopoeus irminia, and provides a general framework for approaching patients with tarantula exposures.CASE REPORT: A 35-year-old man presented to an emergency department 4 h after experiencing a bite from his pet VST. He developed erythema, pain, and edema to the bite site on the left thena...
Source: Pain Physician - August 27, 2023 Category: Anesthesiology Authors: Mark Simon Christopher Hoyte Source Type: research

Impact of histamine-2 antagonist shortage on the incidence of hypersensitivity reactions to paclitaxel: a reconsideration of premedication protocols in France (PACLIREACT Study)
ConclusionWe did not find substantial evidence of an increased risk of HSR due to the absence of H2A in the premedication protocols for paclitaxel. Thus, in contrary to the existing literature on paclitaxel, our findings support the use of a premedication protocol without H2A. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - July 13, 2023 Category: Drugs & Pharmacology Source Type: research