Effectiveness of oral famotidine in reducing the hematologic complications of radiotherapy in patients with esophageal and cardia cancers: a randomized controlled trial
Chemoradiotherapy complications has always been of great concern to both clinicians and patients during the course of treatment. The purpose of the present study was to examine the effectiveness of oral famoti... (Source: Radiation Oncology)
Source: Radiation Oncology - May 20, 2023 Category: Cancer & Oncology Authors: Mina Rostami, Omid Yelghi, Zhaleh Karimi Moghaddam, Alireza Zeraatchi, Hamed Rezaeejam and Alireza Sadeghi Tags: Research Source Type: research

Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non ‑eradication treatment of duodenal ulcer: A network meta‑analysis
In conclusion, pantoprazole (40 mg once daily) was the best choice for the initial non-eradication treatment of patients with duodenal ulcer, and cimetidine (400 mg twice daily), omeprazole (20 mg once daily), lansoprazole (15 mg once daily), ilaprazole (5 mg once daily) and rabeprazole (10 mg once daily) could be used as the first choice. If the aforementioned pharmaceuticals cannot be prescribed, famotidine (40 mg twice daily) is recommended.PMID:37206569 | PMC:PMC10189747 | DOI:10.3892/etm.2023.11971 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 19, 2023 Category: General Medicine Authors: Xiangbo Meng Xiuying Zhu Baixue Li Jibin Liu Jiawei Zhao Hua Wang Quansheng Feng Yue Su Source Type: research

Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin ®-induced gastric ulcers in Wistar rats: anxiolytic behavioural effect, antioxidant activity, and protective pathways
ConclusionData presented a significant protective effect ofAloe vera gel and geranium against Aspirin ®-induced GU; they reduced gastric mucosal injury with potential anxiolytic effects through their anti-inflammatory and antioxidant properties. Therefore, they may be considered promising agents for preventing or treating gastric ulceration. (Source: Inflammopharmacology)
Source: Inflammopharmacology - May 15, 2023 Category: Drugs & Pharmacology Source Type: research

Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease
ConclusionsThe results of this study revealed that both fixed and weight-based adaptive dosing schemes can be appropriate for target attainment across all PSZ formulations, including suspension. Additionally, covariate analysis suggests that concomitant proton pump inhibitors should be contraindicated during PSZ suspension dosing. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - May 14, 2023 Category: Drugs & Pharmacology Source Type: research

Merging konjac glucomannan with other copolymeric hydrogels as a cutting-edge liquid raft system for dual delivery of etoricoxib and famotidine
This study aimed to formulate and evaluate a floating raft system for the co-delivery of etoricoxib (ETO) and famotidine (FAM) using a combination of glucomannan with natural/semi-synthetic polysaccharides. Formulation variables affect gelation lag time (GLT), floating lag time (FLT), and release percentage of drugs after 1-8 h, Stability, and viscosity parameters were evaluated. In vivo X-ray studies, followed by the pharmacokinetic study, were performed on human volunteers. Formulations exhibited pseudoplastic behavior for ease of swallowing. The optimum raft system (ORS) comprised 1% Na alginate, 0.1% Low Methoxyl (LM) ...
Source: Drug Delivery - March 17, 2023 Category: Drugs & Pharmacology Authors: Nabil A Shoman Marwa Saady Mahmoud Teaima Rehab Abdelmonem Mohamed A El-Nabarawi Sammar Fathy Elhabal Source Type: research