Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation
In conclusion, in light of the results that we obtained, 50 mg/kg taxifolin was revealed to have anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.PMID:37331803 | DOI:10.1538/expanim.22-0065 (Source: Experimental Animals)
Source: Experimental Animals - June 18, 2023 Category: Research Authors: Serkan Cerrah Nergiz Akbas Fatih Özcicek Renad Mammadov Durdu Altuner Halis S üleyman Seval Bulut Source Type: research

Effect of felodipine on indomethacin-induced gastric ulcers in rats
Exp Anim. 2023 Jun 13. doi: 10.1538/expanim.23-0052. Online ahead of print.ABSTRACTFelodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically i...
Source: Experimental Animals - June 14, 2023 Category: Research Authors: Nergis Akba ş Bahad ır Süleyman Renad Mammadov Mine G ülaboğlu Emin Murat Akba ş Halis S üleyman Source Type: research

Evaluation of the Efficacy and Safety of DW1903 in Patients with Gastritis: A Randomized, Double-Blind, Noninferiority, Multicenter, Phase 3 study
CONCLUSIONS: DW1903 of a low-dose PPI was not inferior to DW1903R1 of H2RA. Thus, lowdose PPI can be a novel option for treating gastritis (ClinicalTrials.gov Identifier: NCT05163756).PMID:37309193 | DOI:10.5009/gnl220446 (Source: Gut and Liver)
Source: Gut and Liver - June 13, 2023 Category: Gastroenterology Authors: Jie-Hyun Kim Hwoon-Yong Jung In Kyung Yoo Seon-Young Park Jae Gyu Kim Jae Kyu Sung Jin Seok Jang Gab Jin Cheon Kyoung Oh Kim Tae Oh Kim Soo Teik Lee Kwang Bum Cho Hoon Jai Chun Jong-Jae Park Moo In Park Jae-Young Jang Seong Woo Jeon Jin Woong Cho Dae Hwan Source Type: research