Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
