A 64-Year-Old Man With Multifocal Infiltrates
Chest. 2021 Mar;159(3):e151-e154. doi: 10.1016/j.chest.2020.09.082.ABSTRACTA 64-year-old previously healthy man presented with 8 weeks of progressive dyspnea on exertion and cough. Prior to presentation, the patient was able to bicycle > 60 miles per week and work full-time in a home improvement store. He was up-to-date with age-appropriate cancer screening and immunizations, and home medications included famotidine for reflux and nonsteroidal antiinflammatories for osteoarthritis, both as-needed. He had no significant respiratory exposure, aside from previous work as an electrician. His symptoms began in mid-February 2...
Source: Chest - March 8, 2021 Category: Respiratory Medicine Authors: Dylan Werst Brittany Scarpato Sean J Callahan Mary Beth Scholand Source Type: research
A 64-Year-Old Man With Multifocal Infiltrates
Chest. 2021 Mar;159(3):e151-e154. doi: 10.1016/j.chest.2020.09.082.ABSTRACTA 64-year-old previously healthy man presented with 8 weeks of progressive dyspnea on exertion and cough. Prior to presentation, the patient was able to bicycle > 60 miles per week and work full-time in a home improvement store. He was up-to-date with age-appropriate cancer screening and immunizations, and home medications included famotidine for reflux and nonsteroidal antiinflammatories for osteoarthritis, both as-needed. He had no significant respiratory exposure, aside from previous work as an electrician. His symptoms began in mid-February 2...
Source: Chest - March 8, 2021 Category: Respiratory Medicine Authors: Dylan Werst Brittany Scarpato Sean J Callahan Mary Beth Scholand Source Type: research
The Associations Between Pharmacologic Gastric Acid Suppression and Adverse Outcomes in Patients with COVID-19
We read with interest the article by Kamal et al1 evaluating the association between famotidine or proton pump inhibitor (PPI) use and outcomes in patients with coronavirus disease 2019 (COVID-19) in a meta-analysis. The authors found that there is lack of consistent associations between pharmacological gastric acid suppression (famotidine an d PPI) and adverse outcomes in patients with COVID-19. Because their findings are important to both current practice and future research, several questions deserve attention. (Source: Gastroenterology)
Source: Gastroenterology - March 8, 2021 Category: Gastroenterology Authors: Cong Dai, Min Jiang, Yu-hong Huang Tags: Correspondence Source Type: research
In Reply –Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19
Kow and colleagues' interest in our recent letter to the editor1 regarding the potential for famotidine in COVID-19 infection was much appreciated. Obviously, their meta-analysis is small and probably not adequately powered but still suggested 37% and 7% reductions in severe disease in the general and adjusted analyses, respectively: obviously, with wide confidence intervals that were not close to statistical significance. A large-scale randomized study that was adequately powered, preferably with famotidine, started early in COVID-19, would be required to fully determine the full potential of the benefits of famotidine in...
Source: Mayo Clinic Proceedings - March 5, 2021 Category: Internal Medicine Authors: Carl J. Lavie Tags: Letter to the editor Source Type: research
Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19: A Meta-Analysis
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 5, 2021 Category: Internal Medicine Authors: Chia Siang Know, Ismail Abdul Sattar Burud, Syed Shahzad Hasan Tags: Letter to the Editor Source Type: research
In Reply – Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19: A Meta-Analysis
(Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 5, 2021 Category: Internal Medicine Authors: Carl J. Lavie Tags: Letter to the Editor Source Type: research
Use of Famotidine and Risk of Severe Course of Illness in Patients With COVID-19
The article by Ghosh et al,1 in which they discuss the potential of famotidine to regulate innate and adaptive immune responses, provides a rationale to repurpose famotidine for the treatment of coronavirus disease 2019 (COVID-19). There have been few studies evaluating the use of famotidine in patients with COVID-19, an d thus we performed a meta-analysis to summarize the overall effect of famotidine on the clinical outcomes in this patient population. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 5, 2021 Category: Internal Medicine Authors: Chia Siang Kow, Ismail Abdul Sattar Burud, Syed Shahzad Hasan Tags: Letter to the editor Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
Evaluation of cerebral blood flow in the hippocampus, thalamus, and basal ganglia and the volume of the hippocampus in dogs before and during treatment with prednisolone
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that GC administration reduced CBF in the hippocampus and thalamus in dogs of the present study, similar to that which occurs in humans. Research on GC-related brain alteration in dogs could potentially contribute to advancements in understanding Alzheimer disease in humans and neurodegenerative conditions in dogs.PMID:33629902 | DOI:10.2460/ajvr.82.3.230 (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - February 25, 2021 Category: Veterinary Research Authors: Kentaro Yamazaki Aritada Yoshimura Shunsuke Miyahara Shoma Sugi Maho Itono Mina Kondo Nanako Tsuji Miki Shimizu Ryuji Fukushima Miori Kishimoto Source Type: research
