Impact of stress, immunity, and signals from endocrine and nervous system on fascia.
Authors: Barsotti N, Chiera M, Lanaro D, Fioranelli M Abstract The stress response, by virtue of release of glucocorticoids and catecholamines and by modifying the endocrine, neural, and immune responses, can impact the function of the fibroblasts and myofibroblasts that reside throughout the body and more specifically in the fascia, a ubiquitous and multi-functional connective tissue that supports the body. In the present paper, we review these stress-induced responses relying on psychoneuroendocrineimmunology. PMID: 33048774 [PubMed - in process] (Source: Frontiers in Bioscience - Elite)
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Animal models for research on endometriosis.
Authors: Taniguchi F, Wibisono H, Mon Khine Y, Harada T Abstract Endometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in women. Due to the expense in carrying endometriosis research in primates, other models have been developed for understanding the pathobiology and potential treatment of endometriosis. This includes explanting human endometrial tissues in athymic nude mice ...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress.
Authors: Olofinnade AT, Onaolapo AY, Stefanucci A, Mollica A, Olowe OA, Onaolapo OJ Abstract Cucumeropsis mannii (CM) belongs to the melon family and is native to West Africa. There is a paucity of information on its medicinal or nutraceutical potential. Here, we examined the impact of CM in mice that were treated with a normal or a high fat diet (HFD). The CM extracts had a high levels of phenols, flavonoids, ascorbic acid and significant antioxidant activity. Treatment of mice with a HFD diet, led to the memory impairment. However, mice on HFD and received CM, despite increased food intake, showed a decrease in t...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Yoga and its impact on chronic inflammatory autoimmune arthritis.
Authors: Gautam S, Kumar U, Dada R Abstract Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune diseases, which adversely affects the quality of life. RA is a disease of unknown etiology, however, both genetic and environmental factors appear to contribute to the susceptibility to this disease. The severity and progression of the disease are attributable to the release of a host of inflammatory cytokines, cytotoxic and immune regulatory factors. The treatments of RA are primarily limited to symptomatic alleviation of pain or other symptoms or to the use of cytotoxic drug treatment in...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Insights into the COVID-19 pandemic: Origin, pathogenesis, diagnosis, and therapeutic interventions.
Authors: Berekaa MM Abstract Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the human coronavirus (HCoV) family that targets the lower part of the respiratory tract and causes severe acute respiratory syndrome (SARS). In a short span of time, this infection has led to a global pandemic and has become a significant threat to the existence of present human society. Currently, there are no treatments for this infection and the measures established across various countries such as social distancing, usage of mask to prevent entry of the virus into t...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Modulation of human ovarian function by melatonin.
The objective of this review is to recapitulate the current understanding of the role of melatonin and its receptors. PMID: 33048779 [PubMed - in process] (Source: Frontiers in Bioscience - Elite)
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Therapeutic applications of transdermal microneedles.
Authors: Kumar Singla S, Muthuraman A, Sahai D, Mangal N, Dhamodharan J Abstract Transdermal drug-delivery systems (TDDS) offer an attractive alternative to the oral route for delivery of biotherapeutics. Technological advancements in the past few decades have revolutionized the fabrication of micro-structured devices including creation of microneedles (MC). These devices are used for delivering peptides, macromolecules such as proteins and DNA, and other therapeutics through the skin. Here, we review the current use of MCs as a cost effective method for the self-administration of therapeutics. We will then review ...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Molecular stability of the rabbit and chicken egg yolk immunoglobulins.
Authors: Gandhi S, Alshehri SM Abstract Antibodies play a vital role in a variety of applications from diagnostics, imaging, and therapeutics. The stability of antibodies is one of the most important key attributes for its prolonged activity and functionality. Here, we demonstrate a detailed comparative study of the molecular stability of the rabbit immunoglobulin G (IgG) and chicken egg yolk immunoglobulin Y (IgY) at different pH, temperatures, and time points. The molecular stability of IgG and IgY is compared on the basis of its binding activity and conformational changes. The optimum temperature and time were f...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Wellbeing differences in children with synaesthesia: anxiety and mood regulation.
Authors: Simner J, Smees R, Rinaldi LJ, Carmichael DA Abstract Synaesthesia is a neurodevelopmental trait that causes unusual sensory experiences (e.g., perceiving colours when reading letters and numbers). Our paper represents the first evidence that synaesthesia can impact negatively on children's well-being, and that there are likely to be important mental health co-morbidities for children with synaesthesia. We recruited 76 synaesthetes aged 6-10 years who had one of two types of synaesthesia (grapheme-colour synaesthesia and sequence-personality synaesthesia), and compared them to almost one thousand matched n...
Source: Frontiers in Bioscience - Elite - October 15, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Analysis of genetic diversity in indian natural populations of  drosophila ananassae.
Analysis of genetic diversity in indian natural populations of drosophila ananassae. Front Biosci (Elite Ed). 2020 Jun 01;12:237-253 Authors: Singh P, Narula P, Azad S Abstract Forty five natural populations of Drosophila ananassae, collected from entire geo-climatic regions of the India were analyzed to determine the distribution of genetic diversity relative to different eco-geographic factors. Quantitative data on the frequencies of three cosmopolitan inversions in the sampled populations were utilized to deduce Nei's gene diversity estimates. Populations were grouped according to the...
Source: Frontiers in Bioscience - Elite - May 31, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

G82S RAGE polymorphism is associated with Alzheimer's disease.
Authors: Chellappa RC, Rani P Abstract Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimer's disease (AD) due to its ability to interact with amyloid beta and to elicit an inflammatory response. sRAGE, one of the splice variants of RAGE, has been reported to be a decoy receptor for amyloid beta peptides. The present study addresses the occurrence of G82S RAGE polymorphism in AD, and its association with the expression of sRAGE and amyloid beta load (Aβ peptide). The results indicated that the heterozygous genotype (GS) was distributed more than the wild g...
Source: Frontiers in Bioscience - Elite - March 3, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Personality profile of child synaesthetes.
Authors: Rinaldi LJ, Smees R, Carmichael DA, Simner J Abstract Previous research into personality and synaesthesia has focused on adult populations and yielded mixed results. One particular challenge has been to distinguish traits associated with synaesthesia, from traits associated with the ways in which synaesthetes were recruited. In the current study we addressed recruitment issues by testing randomly sampled synaesthetes, and we looked particularly at synaesthesia in childhood. Our child synaesthetes were identified by a screening program across 22 primary schools in the South East of England (n = 3387; childr...
Source: Frontiers in Bioscience - Elite - March 3, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Effects of human milk oligosaccharides (HMOs) on gastrointestinal health.
Authors: Salamone M, Di Nardo V Abstract Gastrointestinal (GI) health of newborns is maintained by the gastrointestinal microbiome, and the PNEI (psychoneuroendocrinoimmunology) system and can be altered by the delivery mode of the milk to the newborn such as breast versus bottle feeding, exposure to antibiotics in the milk, or exposure to environmental pollutants. The health of GI tract is particularly is maintained by breast feeding since the maternal milk provides micro- and macronutrients essential to growth, as well as multifunctional small oligosaccharides, particularly, 2'-fucosyllactose which maintain the G...
Source: Frontiers in Bioscience - Elite - March 3, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Influence of KCNJ11 gene polymorphism in T2DM of south Indian population.
Authors: Aswathi R, Viji D, Pricilla Charmine PS, Akram Husain RSR, Noorul Ameen SH, Ahmed SS, Ramakrishnan V Abstract Type-2 Diabetes mellitus (T2DM) is a complex metabolic disease. A case-control study was conducted with 218 T2DM and 214 controls to evaluate the T2DM risk of rs5219 polymorphism in the south Indian population. The analysis of allelic and genotype data showed a significant association of rs5219 polymorphism towards an increased risk of T2DM compared to controls with an odds ratio (OR) of 2.52, confidence interval (CI) (0.96-6.64) and p-value 0.046. The functional influence of rs5219 was tested whic...
Source: Frontiers in Bioscience - Elite - March 3, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Deregulation of cell growth and apoptosis in UV-induced melanomagenesis.
Authors: Ouhtit A, Gupta I, Gaur RL, Fernando A, Abd El-Azim AO, Eid A Abstract We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to elucidate further the coordinated molecular mechanisms occurring during early UVB exposure. Our results showed that melanocytes expressed p16 only at a high UVB dose, with undetectable p53. The Bax/Bcl2 ratio increased at higher dose, indicating that the cells had selected apoptosis program. In the wt-p16 melanoma cells...
Source: Frontiers in Bioscience - Elite - March 3, 2020 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Fucoidan serves a neuroprotective effect in an Alzheimer's disease model.
Authors: Subaraja M, Anantha Krishnan D, Edwin Hillary V, William Raja TR, Mathew P, Ravikumar S, Gabriel Paulraj M, Ignacimuthu S Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes memory and cognitive deficits. The present study was carried out to evaluate the protective effects of fucoidan in monocrotophos induced AD in Drosophila melanogaster. In silico studies showed that fucoidan exhibited binding energy of -9.3 kcal with proteins. Consistent with this, fucoidan, in a dose and time-dependent fashion, had inhibitory activity against cholinergic and monoamine-metabolized e...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Pheromone baited biopesticide for control of Leucinodes orbonalis Guenee in brinjal plant.
Authors: Nusra MSF, Paranagama PA, Amarasinghe LD, Udukala DN Abstract Leucinodes orbonalis Guenee, Brinjal fruit and shoot borer (BFSB), is the major pest on brinjal world wide. Larvae of this pest cause the damage; which at initial stages adversely affect the shoot growth, and in later stages diminish fruit quality. Spraying of insecticides is the main pest control method. This has been absolutely ineffective due to concealed habit of the larvae. Such a phenomenon apprehends to the development of insecticides resistance which demands continuously increasing doses. Manipulating the insect behavior using semiochemi...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Role of miRNA clusters in epithelial to mesenchymal transition in cancer.
Authors: Shukla V, Adiga D, Jishnu PV, Varghese VK, Satyamoorthy K, Kabekkodu SP Abstract Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Preventative effects of alpha-naphtho flavone in vascular dementia.
Authors: Rishitha N, Muthuraman A Abstract Vascular dementia (VaD) refers to the loss of reasoning, planning, judgment, and memory as a result of reduced blood flow, inflammation, activation of immune cells, and neurodegenerative processes. Here, we tested the preventive effects of alpha-naphthoflavone (ANF) on a model of vascular dementia induced by four-vessel occlusion (4VO) in rats. Animals were treated orally for 5 consecutive days with 10 mg/kg of donepezil (a traditional therapeutic drug) and 40 and 80 mg/kg ANF. The treatment with ANF exerted effects that were similar to those induced by donepezil. This inc...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Predictive value of coronary artery calcium score in cardiovascular disease.
Authors: Liu S, Zheng X, Xu J, Wang X, Zhang Y, Lv B, Zheng L, Sun K Abstract We investigated coronary heart disease (CHD) and cardiovascular disease (CVD) event rates in a diverse population with a coronary artery calcium score (CACS) of 0 and the role of CACS in the detection of subclinical noncalcified atherosclerotic plaque. A total of 15,884 participants in five studies were included in this meta-analysis. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated. The results showed that CHD incidence significantly increased with increased CACS (HR=0.05, 95% CI 0.03-0.06, Z=5.82, P=0.002). Th...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Amplification of speckle-microscope signal by using gold nanoparticle stable of contents.
Authors: Ulianova OV, Filonova NN, Ulyanov SS, Dykman LA, Larionova OS, Feodorova VA Abstract Speckle-microscopy is used for the detection of Chlamydia trachomatis in aqueous suspensions or on slides. Monoclonal antibody tagged with gold nanoparticles that form biospeckles have also been used with a small number of scatterers. By devising a prototype of laser scanning speckle-microscope, we now demonstrate that the signal of speckle microscope can be significantly amplified in the presence of gold nanoparticles. This enhancement of signal emitted from gold nanoparticles offers a better approach to the detection of ...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Neuroprotective effects of resveratrol in Alzheimer's disease.
Authors: Rao YL, Ganaraja B, Joy T, Pai MM, Ullal SD, Murlimanju BV Abstract Alzheimer's disease (AD) is a neurodegenerative disorder, which is commonly seen in older individuals. This is characterized by cognitive dysfunction, which leads to dementia. Pharmacological treatments for AD are mainly targeted on its symptoms like memory loss and cognitive impairment. The pathophysiology involved in AD is intra-neuronal accumulation of hyper-phosphorylated tau protein as neurofibrillary tangle and extra cellular beta amyloid plaque deposition, which is due to oxidative stress. Here we review the neuro-protective effects...
Source: Frontiers in Bioscience - Elite - October 7, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Identification of salt-tolerant cowpea genotypes using ISSR markers and proteome analysis.
Authors: Mini ML, Sathya M, Essa MM, Al-Saadi AM, Jayachandran KS, Anusuyadevi M Abstract Soil salinity globally affects the productivity of staple food crops. Therefore, an understanding of the molecular mechanisms that lead to salt tolerance induced by antioxidant mechanisms can assist in the development of salt-tolerant crops. To decipher the molecular fingerprint of salt resistance, in this study, six salt-tolerant cowpea genotypes at the seedling stage were assessed for their antioxidant responses, yield, genetic polymorphism and proteomics under salt stress. Leaves and roots showed distinct tissue-specific re...
Source: Frontiers in Bioscience - Elite - May 29, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Epithelial-to-mesenchymal transition: Event and core associates in bladder cancer.
Authors: Garg M, Singh R Abstract Urothelial carcinoma of the bladder (UCB) shows different biological outcomes, diverse biological propensities for invading the muscularis as well as epithelial-to-mesenchymal transition (EMT), a dynamic key event during developmental processes, wound healing, and tissue repair. The EMT core molecules include EMT-activating transcription factors (EMT-ATFs), and a host of downstream effectors and target genes including extracellular inducers and growth factors. Here, we describe molecular regulatory determinants of mesenchymal-to-epithelial transition (MET) and more specifically EMT...
Source: Frontiers in Bioscience - Elite - May 29, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Wilson's disease: A new perspective review on its genetics, diagnosis and treatment.
Authors: Saba L, Tiwari A, Biswas M, Gupta SK, Godia-Cuadrado E, Chaturvedi A, Turk M, Suri HS, Orru S, Sanches JM, Carcassi C, Marinho RT, Asare CK, Khanna NN, B K M, Suri JS Abstract Wilson's disease (WD) is an autosomal recessive disorder which is caused by poor excretion of copper in mammalian cells. In this review, various issues such as effective characterization of ATP7B genes, scope of gene network topology in genetic analysis, pattern recognition using different computing approaches and fusion possibilities in imaging and genetic dataset are discussed vividly. We categorized this study into three major sec...
Source: Frontiers in Bioscience - Elite - May 29, 2019 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Demethoxycurcumin ameliorates rotenone-induced toxicity in rats.
Authors: Ramkumar M, Rajasankar S, Swaminathan Johnson WM, Prabu K, Venkatesh Gobi V Abstract Rotenone, an environmental toxin, is used to induce neurodegeneration in both the cellular and animal model of Parkinson's disease. Demethoxycurcumin (DMC), derivative of curcumin has been reported to have antioxidant and anti-inflammatory characteristics in in vitro and in vivo PD conditions. The present study was aimed to evaluate the efficacy of DMC in the management of neurodegeneration in PD. Male Wistar rats were radomized and divided into control, rotenone, DMC +rotenone and rotenone alone treated animals....
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson's disease.
In conclusion, the present study shows that A. blazei extract act as potential neuroprotective agent in the management of Parkinsonism. PMID: 30468634 [PubMed - in process] (Source: Frontiers in Bioscience - Elite)
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Fisetin protects against rotenone-induced neurotoxicity through signaling pathway.
Authors: Rajendran M, Ramachandran R Abstract The present study was designed to evaluate the protective effect of fisetin against rotenone induced toxicity in SH-SY5Y neuroblastoma cellular model of Parkinson's disease (PD). SH-SY5Y neuroblastoma cells were treated with fisetin (5µM) 2 hr prior to being treated with rotenone (100 nM). Following the exposure of SH-SY5Y cells to rotenone, there was marked decreased cell viability, increased oxidative stress, activation of caspase-3 and apoptosis (dual staining, expressions of pro-apoptotic and anti-apoptotic indices). However pretreatment wi...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Three-dimensional printing as an educational tool in colorectal surgery.
Authors: Bangeas P, Drevelegas K, Agorastou C, Tzounis L, Chorti A, Paramythiotis D, Michalopoulos A, Tsoulfas G, Papadopoulos VN, Exadaktylos A, Suri JS Abstract 3D printing is a rapidly advancing technology which represents a significant technological achievement that could be useful in a variety of biomedical applications. In the field of surgery, 3D printing is envisioned as a significant step in the areas of surgical planning, education and training. The 3D printed models are considered as high quality and efficient educational tools. In this paper A randomized controlled trial was performed to compare the edu...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Diagnosis of TB: From conventional to modern molecular protocols.
Authors: Singh P, Saket VK, Kachhi R Abstract Tuberculosis (TB) is an infectious disease caused by different strains of Mycobacterium tuberculosis complex. TB is a curable infection if diagnosed correctly and timely. Late diagnosis and improper treatment may lead to relapse or its escalation to MDR / XDR-TB. TB with HIV co-infection is difficult to diagnose by conventional set-up. Also, detection of child TB and extrapulmonary TB has its own set of problems and is not straightforward to diagnose. The increasing complexity of TB due to the advent of new circulating strains and invasion to the regions where it was no...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Beta2-adrenergic receptor variants in children and adolescents with bronchial asthma.
Authors: Toraih EA, Hussein MH, Ibrahim A, AbdAllah NB, Mohammad E, Kishk AM, Fawzy MS Abstract The region encoding the N-terminal of human β2-adrenergic receptor gene (ADRB2) shows several polymorphisms. To this end, we studied change in susceptibility and/or response to therapy in 175 asthmatic children and adolescents by the two most common variants of the ADRB2 gene namely, rs1042713 (Gly16Arg) and rs1042714 (Gln27Glu). Although, the variants did not correlate with risk of development nor with the severity of the asthma, Gly16/Glu27 haplotype in homozygous individuals conferred protection against developme...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Characterization of embryonic cells obtained from multifetal reduction.
In this study, cells obtained from MFR tissue (termed multifetal reduction embryonic cells (MFR-ECs)), were characterized in vitro by genotypic and phenotypic analyses and tested in vivo by injection under the kidney capsule of nude mice. MFR-ECs were highly proliferative in culture and showed a normal karyotype by microarray CGH. Immunohistochemical analysis at day zero showed positive focal staining for desmin, S-100 protein, synaptophysin and chromogranin. Histology examination showed a mixture of cells from the three germ layers at different stages of differentiation. Markers of these stages included important developm...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Antimicrobial activity of Bacillus subtilis silver nanoparticles.
Authors: Muthulakshmi K, Uma C Abstract We tested the hypothesis that silver nanoparticles (BsAgNPs) made by Bacillus subtilis subsp. inaquosorum exhibit antibacterial and antifungal activities. The bacteria formed nanoparticles in UV-visible spectra with the peak around 430 nanometer detected by surface plasmon resonance and Lambdamax. The FTIR spectra, SEM and XRD revealed the involvement of interaction of biological moieties in the formation of crystalline cuboidal nanoparticles that were had an average size of 10-20 nm. The particles exerted dose dependent antibacterial and antifungal activities and high d...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Beta1-adrenergic receptor antibodies in children with dilated cardiomyopathy.
Authors: Camino M, Morales MD Abstract Autoantibodies to beta-1 adrenergic receptor have been reported in adult patients with dilated cardiomyopathy (DCM). Removal of these antibodies has a positive hemodynamic effect. Our aim was to investigate whether these antibodies are present in children with DCM and explore the potential hemodynamic benefit of immunoadsorption (IA). Seventeen children with DCM  were tested for these antibodies. The etiology of DCM was genetic (n=5), myocarditis (n=4), DCM and congenital heart block (n=3), DCM associated to maternal lupus (n=1), DCM and Wolff Parkinson White Syndrome (n=...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Curcumin prevents cigarette smoke extract induced cognitive impairment.
Authors: Muthuraman A, Thilagavathi L, Jabeen S, Ravishankar SB, Ahmed SS, George T, Rishitha N, Paramakrishnan N Abstract Curcumin is a major phytochemical constituent in Curcuma longa, an herbaceous perennial plant of Zingiberaceae family, which exhibits anti-oxidant, anti-inflammatory and immunomodulatory properties. Here, we studied the therapeutic action of curcumin against CSE induced cognitive impairment in zebrafish. Montelukast (20 mg/kg), a cysteinyl-leukotriene receptor blocker was used as a reference drug. CSE exposure induced biochemical changes revealed that raise the brain acetylcholinesterase activi...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism.
The objective of the present study was to investigate the effects of troxerutin (TX) on Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antiox...
Source: Frontiers in Bioscience - Elite - November 25, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

p53 and P-glycoprotein influence chemoresistance in hepatocellular carcinoma.
Authors: Li S, Gao M, Li Z, Song L, Gao X, Han J, Wang F, Chen Y, Li W, Yang J Abstract Chemoresistance is a critical obstacle to the treatment of hepatocellular carcinoma (HCC). The mechanisms underlying resistance to doxorubicin, cisplatin, and 5-fluorouracil involve p53 and P-glycoprotein (P-gp). p53 plays a role in cell growth; therefore, resistance mechanisms involve chemotherapy-induced apoptosis and p53 mutation and inactivation. P-gp is an energy-dependent drug efflux pump regulated by p53. Its role in drug resistance has provided new insights into the mechanisms underlying the involvement of p53 and P-gp i...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Valeriana wallichii extract inhibits tert-BOOH induced oxidative damage and cytotoxicity.
In conclusion present study revealed the antioxidant and cytoprotective property of VW against oxidative stress. PMID: 29772520 [PubMed - in process] (Source: Frontiers in Bioscience - Elite)
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Myricetin attenuates neurodegeneration and cognitive impairment in Parkinsonism.
Authors: Dhanraj V, Karuppaiah J, Balakrishnan R, Elangovan N Abstract Parkinson's disease (PD) is a progressive neurodegenerative disease due to dopaminergic neuron degeneration. It mostly affects the aged population, leads to memory decline and loss of motor coordination. The present study investigates the neuroprotective role of myricetin a flavonol isolated from the brown seaweed Turbinaria ornata in rotenone induced Drosophila model of PD. Rotenone administration led to dopaminergic neuronal degeneration, dopamine depletion, impaired muscular coordination, gait disturbances, memory decline oxidative stress and...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Bariatric surgery drives major rearrangements of the intestinal microbiota including the biofilm composition.
Authors: Campisciano G, Cason C, Palmisano S, Giuricin M, Rizzardi A, Croce LS, De Manzini N, Comar M Abstract The intestinal microbiota disequilibrium has been associated with obesity, while the role of the gut mucosal biofilms in this pathology is still unknown. We analysed the changes in the intestinal microbiota of obese patients after bariatric surgery with the aim of disclosing the rearrangement of the biofilm configuration. Although the bariatric surgery drives major rearrangements of the gut microbiota, obese patients maintain the Prevotella enterotype before and after surgery, as shown by normal weight pat...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

MHC-B haplotypes impact susceptibility and resistance to RSV-A infection.
Authors: Khare VM, Saxena VK, Tomar A, Singh KP, Singh KB, Tiwari AK Abstract We investigated the impact of haplotype of major histocompatibility complex (MHC)-B on the outcome of infection of Synthetic Dam Line (SDL) broiler strain with Rous Sarcoma Virus (RSV). Genomic analysis of MHC-B haplotypes, revealed a total of 12 known standard haplotypes that constituted to twenty-five different genotypes and one new haplotype of 217 bp size, designated BX. The inoculation of RSV-A in SDL chicks resulted in the development of tumors...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

High incidence of BRAF  V600 mutation in Indian patients with head and neck cancer.
High incidence of BRAF V600 mutation in Indian patients with head and neck cancer. Front Biosci (Elite Ed). 2018 Jun 01;10:520-527 Authors: Gauthaman A, Moorthy A Abstract In cancer cells, BRAF is frequently mutated at codon 600 (V600) leading to the replacement of valine amino acid with other amino acids. The current study was performed to assess the prevalence of BRAFV600 mutation in Indian patients with head and neck squamous cell carcinoma (HNSCC). Among the patients, 27% were homozygous, and 71% were heterozygous for the mu...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Vaginal microbiota dysmicrobism and role of biofilm-forming bacteria.
Authors: Campisciano G, Zanotta N, Petix V, Corich L, De Seta F, Comar M Abstract Bacterial vaginosis involves the presence of a polymicrobial biofilm on the vaginal epithelium, guaranteeing immune escape and spread of antibiotic resistance. To spot known biofilm-forming bacteria, we profiled the vaginal microbiome of sixty-four symptomatic women suffering from a different grade of vaginal disorders and sixty asymptomatic healthy women. Specific microbial profiles distinguished symptomatic from asymptomatic women and characterized the grade of dysmicrobism within the symptomatic group. Lactobacillus crispatus and i...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Marine derived bioactive compounds for treatment of Alzheimer's disease.
Authors: Lakshmi S, Prakash P, Essa MM, Qoronfleh WM, Akbar M, Song BJ, Kumar S, Elumalai P Abstract Alzheimer's disease (AD ) is mounting as social and economic encumbrance which are accompanied by deficits in cognition and memory. Over the past decades, Alzheimer's disease (AD) holds the frontline as one of the biggest healthcare issues in the world. AD is an age related neurodegenerative disorder marked by a decline in memory and an impairment of cognition. Inspite of tedious scientific effort, AD is still devoid of pharmacotherapeutic strategies for treatment as well as prevention. Current treatment strategies ...
Source: Frontiers in Bioscience - Elite - May 21, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Daily subcutaneous testosterone for management of testosterone deficiency.
Authors: Yazdani N, Matthews Branch S Abstract Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels, pellets, and oral preparations. The use of testosterone alone has been linked to various adverse effects including, infertility, testicular atrophy, erythropoiesis, and gynecomastia. To determine the effectiveness of therapy using the Daily Subcutaneous Testosterone (DST) method i...
Source: Frontiers in Bioscience - Elite - January 5, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Modifying progression of aging and reducing the risk of neurodegenerative diseases by probiotics and synbiotics.
Authors: Lye HS, Lee YT, Ooi SY, Teh LK, Lim LN, Wei LK Abstract Aging, which affects most of the multi-cellular organisms, is due to a potentially complex set of mechanisms that collectively cause a time-dependent decline of physiological functions. Aging restrains longevity and leads to neurodegenerative diseases including dementia, Alzheimer's disease and lacunar stroke. Human microbiota is now considered to have a strong impact on the progression of aging. The impact of aging and the risk of neurodegenerative diseases can be reduced by using probiotics, or preferably by combining probiotics and prebiotics,...
Source: Frontiers in Bioscience - Elite - January 5, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Nanoantibiotics: Future nanotechnologies to combat antibiotic resistance.
Authors: Muzammil S, Hayat S, Fakhar-E-Alam M, Aslam B, Siddique MH, Nisar MA, Saqalein M, Atif M, Sarwar A, Khurshid A, Amin N, Wang Z Abstract The discovery of antibiotics was hailed as a historic breakthrough for the human race in the fight against bacterial and malignant infections. However, in a very short time, owing to their acute and aggressive nature, bacteria have developed resistance against antibiotics and other chemotherapeutics agents. Potentially, this situation could again result in bacterial infection outbreaks. Metal and metal oxide nanoparticles have been proven as better alternatives; the combin...
Source: Frontiers in Bioscience - Elite - January 5, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Five- hit hypothesis in ATM gene: An individualized model in a breast cancer patient.
Authors: Mehdipour P, Azarnezhad A Abstract The aim of this study was to trace D1853N in a proband affected with primary BC to explore the molecular, cellular and structural aspects of ATM. Exon 37 and splicing regions were PCR-sequenced. Allelic location of the alterations was determined by molecular cloning. Possible impact of alterations was investigated through the bioinformatics and protein expression assays. Five genetic variants including IVS 36-91 AA>TT, IVS 36-8 T>C, D1853N, IVS 37+47 A>G, IVS 37+60 Del T were found in the target regions of ATM and all the alterations were occurred heterezygously....
Source: Frontiers in Bioscience - Elite - January 5, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Pathomechanisms of polycystic ovary syndrome: Multidimensional approaches.
Authors: Sagvekar P, Dadachanji R, Patil K, Mukherjee S Abstract Polycystic ovary syndrome is a complex endocrine disorder affecting numerous women of reproductive age across the globe. Characterized mainly by irregular menses, hirsutism, skewed LH: FSH ratios and bulky polycystic ovaries, this multifactorial endocrinopathy results in unfavorable reproductive and metabolic sequelae, including anovulatory infertility, type 2 diabetes, metabolic syndrome and cardiovascular disease in later years. Increasing evidence has shown that the manifestation of polycystic ovary syndrome (PCOS) is attributable to a cumulative i...
Source: Frontiers in Bioscience - Elite - January 5, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Prostate cancer susceptibility and growth linked to Y chromosome genes.
Authors: Patel R, Khalifa AO, Isali I, Shukla S Abstract The role of Y chromosome in prostate cancer progression and incidence is not well known. Among the 46 chromosomes, Y chromosome determines the male gender. The Y chromosome is smaller than the X chromosome and contains only 458 genes compared to over 2000 genes found in the X chromosome. The Y chromosome is prone to high mutation rates, created exclusively in sperm cells due to the highly oxidative environment of the testis. Y chromosome harbors epigenetic information, which affects the expression of genes associated with the incidence and progression of pros...
Source: Frontiers in Bioscience - Elite - January 5, 2018 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research