Ruptured giant thoracic hydatid cyst presenting with respiratory symptoms
We present the case of a 22-year-old college student who presented with progressive dyspnea, chest pain, fever, cough, and hemoptysis. Imaging revealed a giant cystic lesion and “water lily” sign within the left hemithorax. A giant hydatid cyst was removed by posterolateral thoracotomy. Thorough history, physical examination, and appropriate imaging studies, are crucial for accurate diagnosis. Key messagePulmonary hydatid disease remains a global public health issue. Symptoms often result from cyst rupture, causing fever, cough, and hemoptysis. Radiographs may show homogeneous masses, air-fluid levels, or the pathognom...
Source: Respirology Case Reports - April 4, 2024 Category: Respiratory Medicine Authors: Reza Ershadi,
Hesam Amini,
Ghazal Roostaei,
Hossein Kazemizadeh,
Leila Mollamohammadi,
Niloofar Khoshnam Rad Tags: CLINICAL IMAGE Source Type: research
Therapeutic effect of curcumin nanoemulsion on cystic echinococcosis in BALB/c mice: a computerized tomography (CT) scan and histopathologic study evaluation
This study aimed to determine the therapeutic efficacy of curcumin nanoemulsion (CUR-NE) in mice infected with Echinococcus granulosus sensu stricto protoscoleces. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 4, 2024 Category: Complementary Medicine Authors: Mohamad Ghanimatdan, Seyed Mahmoud Sadjjadi, Fattaneh Mikaeili, Aref Teimouri, Seyed Hamed Jafari, Amin Derakhshanfar and Saeideh Hashemi-Hafshejani Tags: Research Source Type: research
Molecular characterization of cystic echinococcosis cysts isolated from cattle in Shiraz, Iran
AbstractCystic echinococcosis (CE), is one of the common parasitic infections of domestic animals and humans caused by the larval stages of the tapewormEchinococcus granulosus. This research aimed to identify of CE cysts in cattle isolates from Shiraz slaughterhouse using molecular technique. Thirty CE cysts isolates were collected and total DNA was extracted from protoscolices or the germinal layer of each cyst followed by polymerase chain reaction (PCR) using cytochrome c oxidase I (cox1) and NADH dehydrogenase subunit 1 (NADH-1) mitochondrial genes (~ 450 bp) and sequencing. The sequence results were compared with a...
Source: Journal of Parasitic Diseases - April 2, 2024 Category: Parasitology Source Type: research
Infectious Diseases of the Brain and Spine
Atypical infections of the brain and spine caused by parasites occur in immunocompetent and immunosuppressed hosts, related to exposure and more prevalently in endemic regions. In the United States, the most common parasitic infections that lead to central nervous system manifestations include cysticercosis, echinococcosis, and toxoplasmosis, with toxoplasmosis being the most common opportunistic infection affecting patients with advanced HIV/AIDS. Another rare but devastating transmittable disease is prion disease, which causes rapidly progressive spongiform encephalopathies. Familiarity and understanding of various infec...
Source: Magnetic Resonance Imaging Clinics of North America - March 29, 2024 Category: Radiology Authors: Dhairya A. Lakhani, Francis Deng, Doris D.M. Lin Source Type: research
mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection
Alveolar echinococcosis (AE) is an important infectious disease caused by the metacestode larvae of Echinococcus multilocularis, seriously threatening global public health security. Kupffer cells (KCs) play impor... (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 29, 2024 Category: Microbiology Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo and Xuenong Luo Tags: Research Source Type: research
The expression of CTLA-4 in hepatic alveolar echinococcosis patients and blocking CTLA-4 to reverse T cell exhaustion in Echinococcus multilocularis-infected mice
Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by the infection of Echinococcus multilocularis (E. multilocularis) larvae. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) produces inhibitory signals and induces T cell exhaustion, thereby inhibiting the parasiticidal efficacy of the liver immune system. Therefore, the purpose of this study is to explore how T-cell exhaustion contributes to AE and whether blocking CTLA-4 could reverse T cell exhaustion. Here we discovered that the expression of CTLA-4 was increased in the infiltrating margin around the lesion of the liver from AE patients by using western blot...
Source: Frontiers in Immunology - March 28, 2024 Category: Allergy & Immunology Source Type: research
Detection of circulatory E. granulosus-derived cell-free DNA in the plasma and urine of human cystic echinococcosis using an in-house PCR: a potential promising diagnostic biomarker
CONCLUSIONS: Plasma-based PCR has been found to be a reliable diagnostic tool for identifying CE patients at different cyst stages. It offers validity, speed, and sufficient sensitivity, making it an alternative to serology in diagnosing CE in endemic areas.PMID:38536533 | DOI:10.1007/s11033-024-09385-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 27, 2024 Category: Molecular Biology Authors: Bentolhoda Habibi Shirzad Gholami Abouzar Bagheri Mahdi Fakhar Mahdi Torabi Rabeeh Tabaripour Alimohammad Moradi Source Type: research
Detection of circulatory E. granulosus-derived cell-free DNA in the plasma and urine of human cystic echinococcosis using an in-house PCR: a potential promising diagnostic biomarker
CONCLUSIONS: Plasma-based PCR has been found to be a reliable diagnostic tool for identifying CE patients at different cyst stages. It offers validity, speed, and sufficient sensitivity, making it an alternative to serology in diagnosing CE in endemic areas.PMID:38536533 | DOI:10.1007/s11033-024-09385-w (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 27, 2024 Category: Molecular Biology Authors: Bentolhoda Habibi Shirzad Gholami Abouzar Bagheri Mahdi Fakhar Mahdi Torabi Rabeeh Tabaripour Alimohammad Moradi Source Type: research
Exploration of altered miRNA expression and function in MSC-derived extracellular vesicles in response to hydatid antigen stimulation
ConclusionThis study provides insights into the role of MSC-derived EVs in regulating parasite immunity. The findings suggest that hydatid antigens can modulate the expression of miRNAs in MSC-derived EVs, leading to changes in chemokine expression and osteogenic capacity. These findings contribute to a better understanding of the immunomodulatory mechanisms involved in hydatid disease and provide potential therapeutic targets for the development of new treatment strategies. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 27, 2024 Category: Microbiology Source Type: research
Reinfection of farm dogs following praziquantel treatment in an endemic region of cystic echinococcosis in southeastern Iran
by Mehdi Borhani, Mohammad Ali Mohammadi, Mahbod Entezami, Mohammad Reza Baneshi, Saeid Nasibi, Joaquin M. Prada, Majid Fasihi Harandi
Cystic Echinococcosis (CE) as a prevalent tapeworm infection of human and herbivorous animals worldwide, is caused by accidental ingestion ofEchinococcus granulosus eggs excreted from infected dogs. CE is endemic in the Middle East and North Africa, and is considered as an important parasitic zoonosis in Iran. It is transmitted between dogs as the primary definitive host and different livestock species as the intermediate hosts. One of the most important measures for CE control is dog dewo...
Source: PLoS Neglected Tropical Diseases - March 27, 2024 Category: Tropical Medicine Authors: Mehdi Borhani Source Type: research
A man having ‘cyst’ in the ‘cyst’!
We present a case of pulmonary hydatid cyst. Several linear areas of increased attenuation noted within the cyst in its dependent portion, which could represent ruptured cysts. Key messageHydatid disease is a zoonotic parasitic infestation caused by tapeworms, particularlyEchinococcus granulosus. The lung is the second most site followed by liver accounting for 10% –30% of the cases. Rupture of hydatid cyst can occur into pleura or bronchus. Surgery remains the mainstay of treatment for pulmonary hydatid. (Source: Respirology Case Reports)
Source: Respirology Case Reports - March 26, 2024 Category: Respiratory Medicine Authors: Asmita A. Mehta,
Divya Surendran,
Gopika Radhakrishnan Tags: CLINICAL IMAGE Source Type: research
Metabolic mechanism and pharmacological study of albendazole in secondary hepatic alveolar echinococcosis (HAE) model rats
In this study, various ABZ-solubilizing formulations, including albendazole crystal dispersion system (ABZ-CSD), albendazole hydrochloride-hydroxypropyl methylcellulose phthalate composite (TABZ-HCl-H), and albendazole hydroxyethyl sulfonate-hydroxypropyl methylcellulose phthalate composite (TABZ-HES-H), were developed and evaluated. Physicochemical properties as well as liver enzyme activity were analyzed and their pharmacodynamics in an anti-secondary hepatic alveolar echinococcosis (HAE) rat model were investigated. The formulations demonstrated improved solubility, exhibiting enhanced inhibitory effects on microcysts i...
Source: Antimicrobial Agents and Chemotherapy - March 19, 2024 Category: Microbiology Authors: Chaoqun Li Yaogang Zhang Mingquan Pang Yong Zhang Chunhui Hu Haining Fan Source Type: research
Metabolic mechanism and pharmacological study of albendazole in secondary hepatic alveolar echinococcosis (HAE) model rats
In this study, various ABZ-solubilizing formulations, including albendazole crystal dispersion system (ABZ-CSD), albendazole hydrochloride-hydroxypropyl methylcellulose phthalate composite (TABZ-HCl-H), and albendazole hydroxyethyl sulfonate-hydroxypropyl methylcellulose phthalate composite (TABZ-HES-H), were developed and evaluated. Physicochemical properties as well as liver enzyme activity were analyzed and their pharmacodynamics in an anti-secondary hepatic alveolar echinococcosis (HAE) rat model were investigated. The formulations demonstrated improved solubility, exhibiting enhanced inhibitory effects on microcysts i...
Source: Antimicrobial Agents and Chemotherapy - March 19, 2024 Category: Microbiology Authors: Chaoqun Li Yaogang Zhang Mingquan Pang Yong Zhang Chunhui Hu Haining Fan Source Type: research
Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation: A case report
CONCLUSION: Lesions involving the abdominal wall and sinus tract formation, may require radical resection. Long-term prognosis includes albendazole and follow-up examinations.PMID:38495276 | PMC:PMC10941752 | DOI:10.4254/wjh.v16.i2.279 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Miao-Miao Wang Xiu-Qing An Jin-Ping Chai Jin-Yu Yang Ji-De A Xiang-Ren A Source Type: research
Epidemiological survey of cystic echinococcosis in southwest China: From the Qinghai-Tibet plateau to the area of Yunnan
CONCLUSION: Cases of echinococcosis were reported throughout the entire Yunnan province, with the majority distributed in Western Yunnan, suggesting that echinococcosis control should be strengthened in this area. We suggest that an epidemiological investigation should be carried out in the future, based on the clues from newly discovered cases in hospitals or from the CISDCP. The newly discovered cases in the hospital provided clues to comprehensively determine the location of cases and where epidemic spot investigation should be conducted.PMID:38495269 | PMC:PMC10941742 | DOI:10.4254/wjh.v16.i2.229 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Jin-Rong Zi Dan Xiao Jia Peng Fang-Wei Wu Jian-Xiong Li Xin-Liu Yan Zheng-Qing Wang Xuan Cai Qian Xu Ben-Fu Li Ya-Ming Yang Source Type: research
