Peroral endoscopic myotomy for spastic esophageal dysmotility among opioid users: a multicenter propensity score matching study
Opioid-induced esophageal dysfunction (OIED) often presents as spastic esophageal disorders (SEDs) and esophagogastric junction outflow obstruction (EGJOO). The aim of this study was to evaluate and compare clinical outcomes of peroral endoscopic myotomy (POEM) for SEDs and EGJOO among opioid users and nonusers. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 3, 2024 Category: Gastroenterology Authors: BahaAldeen Bani Fawwaz, Yiyang Zhang, Aimen Farooq, Venkata S. Gorrepati, Justin F. Forde, Andrew Canakis, Raymond Kim, Michael Ma, Petros Benias, Simon Che, Michael B. Ujiki, Andrew A. Li, Joo Ha Hwang, Chiemeziem Eke, Prashant Kedia, Abraham Yu, Irteza Tags: Original article Source Type: research
Cardiac Biomarkers In Amyloidosis Predict Small Intestinal Bacterial Overgrowth
This study evaluates associations between cardiac biomarkers (NT-proBNP level, echocardiographic indices) and extracardiac biomarkers in the gut, specifically non-invasive GI breath testing for SIBO. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Frederick Chua, Shoujit Banerjee, David C. Kunkel, Dawn Lombardo, Roxana Ghashghaei Tags: 371 Source Type: research
Impedance planimetry and panometry (EndoFLIP ™) can replace manometry in preoperative anti-reflux surgery assessment
ConclusionImpedance planimetry and panometry can assess motility under general anesthesia or sedation and is highly sensitive to peristaltic dysfunction. Panometry is a novel tool that has potential to streamline and improve patient care and therefore should be considered as an alternative to HRM, especially in patients in which HRM would be inaccessible or poorly tolerated. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - January 1, 2024 Category: Surgery Source Type: research
Evaluating the molecular and genetic mechanisms underlying gut motility disorders
Expert Rev Gastroenterol Hepatol. 2023 Dec 20. doi: 10.1080/17474124.2023.2296558. Online ahead of print.ABSTRACTINTRODUCTION: Gastrointestinal (GI) motility disorders comprise a wide range of different diseases affecting the structural or functional integrity of the GI neuromusculature. Their clinical presentation and burden of disease depends on the predominant location and extent of gut involvement as well as the component of the gut neuromusculature affected.AREAS COVERED: A comprehensive literature review was conducted using the PubMed and Medline databases to identify articles related to GI motility and functional di...
Source: Expert Review of Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Authors: Atchariya Chanpong Maria M Alves Elena Bonora Roberto De Giorgio Nikhil Thapar Source Type: research
Post-bariatric Surgery Changes in Secondary Esophageal Motility and Distensibility Parameters
ConclusionBariatric surgery affects esophageal and GEJ physiology, and it is associated with higher rates of secondary dysmotility. DH patients have even higher rates of dysmotility. Further studies assessing clinical data and their correlation with manometric and pH-metric findings are needed.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - December 20, 2023 Category: Surgery Source Type: research
GSE220038 A Seed Sequence Variant in miR-145-5p causes Multisystem Smooth Muscle Dysfunction Syndrome (MSMDS)
We describe a patient with multiple major manifestations of MSMDS including steno-occlusive cerebrovascular arteriopathy, prune belly syndrome, gastrointestinal dysmotility, bladder dysfunction, and pupillary hyporeactivity without variation in ACTA2. Whole genome sequencing revealed a single nucleotide variant contained within the seed sequence of MIR145, which encodes the smooth muscle associated microRNA; hsa-miR-145-5p. RNA expression analysis on patient-derived fibroblasts was consistent with actin cytoskeletal dysfunction, and mutant miR-145-5p was unable to mediate cytoskeletal modulation of smooth muscle cells. MSM...
Source: GEO: Gene Expression Omnibus - December 14, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Preventative strategies for low anterior resection syndrome
ConclusionsTo date, there is a limited evidence base for all preventative strategies including IONM, RAS, PFP and TAI. These strategies are limited by either access (IONM, RAS and PFP) or acceptability (PFP and TAI), which are both key to the success of any intervention. The results of ongoing trials will serve to assess acceptability, while technological advancement may improve access to some of the aforementioned strategies. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - December 13, 2023 Category: Surgery Source Type: research
Nutrition support in the pediatric total pancreatectomy with islet autotransplantation recipient
Nutr Clin Pract. 2023 Dec 10. doi: 10.1002/ncp.11101. Online ahead of print.ABSTRACTFor children with diminished quality of life and chronic pain caused by acute recurrent or chronic pancreatitis who are undergoing total pancreatectomy with islet autotransplantation, postoperative nutrition support has several unique characteristics. Surgical complications may lead to delays in nutrition support initiation or require modifications to the regimen. Early postoperative dysmotility requires the use of temporary enteral nutrition until this improves. The resultant complete exocrine pancreatic insufficiency necessitates lifelong...
Source: Nutrition in Clinical Practice - December 11, 2023 Category: Nutrition Authors: Elissa M Downs Amanda Brun Melena D Bellin Source Type: research
Nutrition support in the pediatric total pancreatectomy with islet autotransplantation recipient
Nutr Clin Pract. 2023 Dec 10. doi: 10.1002/ncp.11101. Online ahead of print.ABSTRACTFor children with diminished quality of life and chronic pain caused by acute recurrent or chronic pancreatitis who are undergoing total pancreatectomy with islet autotransplantation, postoperative nutrition support has several unique characteristics. Surgical complications may lead to delays in nutrition support initiation or require modifications to the regimen. Early postoperative dysmotility requires the use of temporary enteral nutrition until this improves. The resultant complete exocrine pancreatic insufficiency necessitates lifelong...
Source: Nutrition in Clinical Practice - December 11, 2023 Category: Nutrition Authors: Elissa M Downs Amanda Brun Melena D Bellin Source Type: research
Glutamine Alleviates I/R-Induced Intestinal Injury and Dysmotility Via the Downregulation of Xanthine Oxidase/Uric Acid Signaling and Lactate Generation in Wistar Rats
Disruption of intestinal histoarchitecture and intestinal dysmotility is critical to intestinal ischemia/reperfusion (IR) injury and xanthine oxidase (XO)/uric acid (UA) signaling and increased lactate generation have been reported to play a role. More so, glutamine treatment has been demonstrated to inhibit XO/UA signaling. However, the role of glutamine in intestinal IR injury –induced intestinal dysmotility and the associated mechanisms of action are unclear. Therefore, this study was to investigate the mechanisms underlying the role of glutamine in intestinal IR injury. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - December 8, 2023 Category: Surgery Authors: Roland Eghoghosoa Akhigbe, Bayo-Olugbami Adedamola Aminat, Tunmise Maryanne Akhigbe, Moses Agbomhere Hamed Tags: Gastrointestinal Surgery Source Type: research
Neurogastroenterology and Motility Disorders of the Gastrointestinal Tract in Cystic Fibrosis
AbstractPurpose of ReviewTo discuss all the various motility disorders impacting people with Cystic Fibrosis (PwCF) and provide diagnostic and management approaches from a group of pediatric and adult CF and motility experts and physiologists with experience in the management of this disease.Recent FindingsGastrointestinal (GI) symptoms coexist with pulmonary symptoms in PwCF regardless of age and sex. The GI manifestations include gastroesophageal reflux disease, esophageal dysmotility gastroparesis, small bowel dysmotility, small intestinal bacterial overgrowth syndrome, distal idiopathic obstruction syndrome, constipati...
Source: Current Gastroenterology Reports - December 7, 2023 Category: Gastroenterology Source Type: research
