Association between Esophageal Dysmotility and Long-Term Outcomes in Lung Transplant Recipients
Esophageal dysmotility is very common in lung transplant recipients and is thought to predispose to allograft injury through higher risk of aspiration. At our center, we routinely test lung transplant recipients for esophageal dysmotility with High Resolution Manometry (HRM) at 3 months post-transplant. We hypothesize that lung transplant recipients (LTRs) with significant esophageal dysmotility are more likely to develop lung injury leading to CLAD and death. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: J. Fernandez, E. Huszti, L. Levy, R. Ghany, P. Riddell, C. Chaparro, S. Keshavjee, L.G. Singer, J.C. Yeung, T. Martinu Tags: (136) Source Type: research

The Impact of Gastroesophageal Reflux and Esophageal Motility on Spirometry Following Lung Transplantation
This study examines the interaction of GERD and EsD on spirometry in LTRs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: L.N. Fessler, J. Mathew, K. Bazemore, E. Bush, S. Agbor-Enoh, P.D. Shah Tags: (384) Source Type: research

Should Pre-Transplant Esophageal Dysmotility Preclude Candidacy for Lung Transplantation?
Esophageal dysmotility can decrease luminal clearance and increase the risk of aspiration and GERD and contribute to allograft dysfunction. We sought to determine the impact of pre-transplant esophageal dysmotility on allograft function, GERD, rejection and survival after lung transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: U. Ahmad, H.U. Siddiqui, J. Rappaport, S. Gabbard, A. Tang, C. Lane, O. Akindipe, S. Gadre, C. Lehr, A. Mehta, M. Budev, A. Bribriesco, K. McCurry, E. Blackstone, S. Murthy Tags: (285) Source Type: research

The Effect of Esophageal Dysmotility on Lung Transplant Outcomes
This report investigates the effect of esophageal motility disorders on CLAD after lung transplantation. We hypothesized that esophageal dysmotility will result in more frequent development of CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: H. Kwon, K. Gee, R. Mukherjee, B.C. Gibney Tags: (759) Source Type: research

Autonomic function, postprandial hypotension and falls in older adults at one year after critical illness.
CONCLUSIONS: In older adults who were evaluated 3 and 12 months after ICU discharge, postprandial hypotension at 3 months was associated with an increased risk of subsequent falls, but the prevalence of postprandial hypotension decreased with time. PMID: 32102643 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 28, 2020 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Clinical Relevance of Blood Glucose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus.
Authors: Honda H, Hanayama Y, Obika M, Hasegawa K, Hamahara J, Kishida M, Hagiya H, Ogawa H, Kataoka H, Otsuka F Abstract A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients' gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) s...
Source: Acta Medica Okayama - February 28, 2020 Category: General Medicine Tags: Acta Med Okayama Source Type: research

Usefulness of a Kampo Medicine on Stress-Induced Delayed Gastric Emptying in Mice.
In conclusion, the components of BGH may exert synergistic effects on improving gastric emptying via various targets. BGH is considered to be potentially useful for treating gastrointestinal dysmotility with psychological symptoms. PMID: 32089720 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - February 26, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Severe gastrointestinal haemorrhage from an eroding jejuno-jejunal fistula
We present the case of an 11-year old boy with mosaic trisomy 13 and an end ileostomy (for gut dysmotility) who presented with a catastrophic gastrointestinal haemorrhage during a prolonged Paediatric Intensive Care (PICU) stay recovering from an episode of presumed sepsis. A normal upper GI endoscopy was followed by a laparoscopy which revealed a small bowel adhesion to the anterior abdominal wall which had facilitated the creation of a jejuno-jejunal fistula that had eroded through a mesenteric artery. The child recovered well after a limited laparotomy and segmental small bowel resection.This case highlights an extremel...
Source: Journal of Pediatric Surgery Case Reports - February 24, 2020 Category: Surgery Source Type: research

Dysphagia Lusoria: Is the Dysmotility Connection Illusory or Real?
AbstractDysphagia lusoria is rare embryologic defect of the aortic arch vasculature characterized by an aberrant retro-esophageal course of the right subclavian artery (RSA), comprising a vascular sling. This may manifest clinically with symptoms of dysphagia or reflux. Given the rarity of this pathology, there remains uncertainty regarding the most effective treatment algorithm. Vascular decompression procedure surgery is often used to rectify the aberrant vascular morphology. However, a low percentage of aberrant arteries result in trachea-esophageal symptoms. As such, we suggest (1) one must exclude co-morbid esophageal...
Source: Digestive Diseases and Sciences - February 24, 2020 Category: Gastroenterology Source Type: research

Detecting gastrointestinal manifestations in patients with systemic sclerosis using anti-gAChR antibodies
Patients with systemic sclerosis (SSc) complicated by gastrointestinal dysmotility are difficult to treat and have high mortality. To clarify the pathogenesis of gastrointestinal manifestations, we aimed to de... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 21, 2020 Category: Rheumatology Authors: Shunya Nakane, Masataka Umeda, Shin-ya Kawashiri, Akihiro Mukaino, Kunihiro Ichinose, Osamu Higuchi, Yasuhiro Maeda, Hideki Nakamura, Hidenori Matsuo and Atsushi Kawakami Tags: Research article Source Type: research

Predictors of reflux aspiration and laryngo-pharyngeal reflux
AbstractBackgroundGastro-esophageal reflux disease (GERD) can present with typical or atypical or laryngo-pharyngeal reflux (LPR) symptoms. Pulmonary aspiration of gastric refluxate is one of the most serious variants of reflux disease as its complications are difficult to diagnose and treat. The aim of this study was to establish predictors of pulmonary aspiration and LPR symptoms.MethodsRecords of 361 consecutive patient from a prospectively populated database were analyzed. Patients were categorized by symptom profile as predominantly LPR or GERD (98 GER and 263 LPR). Presenting symptom profile, pH studies, esophageal m...
Source: Esophagus - February 21, 2020 Category: Gastroenterology Source Type: research

Small Bowel Dysmotility, Pseudoobstruction, and Functional Correlation with Histopathology: Lessons Learned
AbstractPurpose of ReviewSmall bowel dysmotility is a broad heterogeneous term that encompasses a wide range of gastrointestinal disorders resulting from abnormal gut motility. Chronic intestinal pseudo-obstruction (CIPO) is a severe, rare, and complex small bowel motility disorder at the extreme end of this spectrum. It is characterized by failure of the intestinal tract to propel contents, which results in signs and symptoms of bowel obstruction albeit in the absence of any obstructive lesion(s). In this article, we discuss up-to-date diagnostic techniques, management options, and histopathological findings in CIPO.Recen...
Source: Current Gastroenterology Reports - February 20, 2020 Category: Gastroenterology Source Type: research

Severe gastrointestinal hemorrhage from an eroding jejuno-jejunal fistula
We present the case of an 11-year old boy with mosaic trisomy 13 and an end ileostomy (for gut dysmotility) who presented with a catastrophic gastrointestinal haemorrhage during a prolonged Paediatric Intensive Care (PICU) stay recovering from an episode of presumed sepsis. A normal upper GI endoscopy was followed by a laparoscopy which revealed a small bowel adhesion to the anterior abdominal wall which had facilitated the creation of a jejuno-jejunal fistula that had eroded through a mesenteric artery. The child recovered well after a limited laparotomy and segmental small bowel resection.This case highlights an extremel...
Source: Journal of Pediatric Surgery Case Reports - February 19, 2020 Category: Surgery Source Type: research

Nausea, Vomiting and Refractory Hiccups: Contemplate Beyond Stomach
Gastrointestinal amyloidosis most notably occurs in the liver and small intestine. Its presentation is highly nonspecific and may include gastrointestinal bleeding, malabsorption syndromes and protein-losing enteropathy. Chronic gastrointestinal dysmotility, while relatively uncommon, carries a particularly grave prognosis. In those with amyloidosis, gastric involvement occurs in 8% of patients with only 1% being symptomatic.1 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 19, 2020 Category: General Medicine Authors: Tian Li, Mouyed Alawad, Rishard Abdul Tags: CLINICAL COMMUNICATION TO THE EDITOR Source Type: research

Nausea, Vomiting, and Refractory Hiccups: A Case of Gastrointestinal Amyloidosis
Gastrointestinal amyloidosis most notably occurs in the liver and small intestine. Its presentation is highly nonspecific and may include gastrointestinal bleeding, malabsorption syndromes, and protein-losing enteropathy. Chronic gastrointestinal dysmotility, while relatively uncommon, carries a particularly grave prognosis. In those with amyloidosis, gastric involvement occurs in 8% of patients, with only 1% being symptomatic.1 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 19, 2020 Category: General Medicine Authors: Tian Li, Mouyed Alawad, Rishard Abdul Tags: CLINICAL COMMUNICATION TO THE EDITOR Source Type: research

On the nature of high-amplitude propagating pressure waves in the human colon.
ON THE NATURE OF HIGH-AMPLITUDE PROPAGATING PRESSURE WAVES IN THE HUMAN COLON. Am J Physiol Gastrointest Liver Physiol. 2020 Feb 18;: Authors: Milkova N, Parsons SP, Ratcliffe E, Huizinga JD, Chen J Abstract Characterization of High-Amplitude Propagating Pressure Waves (HAPWs or HAPCs) plays a key role in diagnosis of colon dysmotility using any type of colonic manometry. With the introduction of high-resolution manometry, more insight is gained into this most prominent propulsive motor pattern. Here we employ a water-perfused catheter with 84 sensors with intervals between measuring points of 1 cm th...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 18, 2020 Category: Physiology Authors: Milkova N, Parsons SP, Ratcliffe E, Huizinga JD, Chen J Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Core Curricular Priorities in the Care of Children with Medical Complexity: A North American Modified Delphi Study
ConclusionEleven curricular priorities in complex care were identified across multiple domains of the ICF framework, serving as a guide for standardized curriculum development for future pediatricians. (Source: Academic Pediatrics)
Source: Academic Pediatrics - February 8, 2020 Category: Pediatrics Source Type: research

Reduced Esophageal Contractility Is Associated with Dysplasia Progression in Barrett ’s Esophagus: A Multicenter Cohort Study
ConclusionIn this retrospective study of 193 BE patients, the majority exhibited abnormal esophageal motor function. Reduced esophageal contractility was independently associated with dysplastic progression in BE. Characterizing esophageal physiology in BE may help to risk stratify patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - February 5, 2020 Category: Gastroenterology Source Type: research

Physiology and Pathophysiology of the Autonomic Nervous System
This article reviews the anatomic, functional, and neurochemical organization of the sympathetic and parasympathetic outputs; the effects on target organs; the central mechanisms controlling autonomic function; and the pathophysiologic basis for core symptoms of autonomic failure. RECENT FINDINGS Functional neuroimaging studies have elucidated the areas involved in central control of autonomic function in humans. Optogenetic and other novel approaches in animal experiments have provided new insights into the role of these areas in autonomic control across behavioral states, including stress and the sleep-wake cycle. SU...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

When is parenteral nutrition indicated in the hospitalized, acutely ill patient?
Purpose of review The current review discusses current practices regarding appropriate indications for parenteral nutrition in acutely ill hospitalized patients. We address-specific indications for parenteral nutrition in the perioperative period, and in inflammatory bowel disease, oncology, hepatobiliary, critical care and end-stage renal disease patients. Recent findings Acutely ill hospitalized patients can develop intestinal failure requiring parenteral nutrition. Recent studies have provided insight into the main indications. The most common indications for inpatient parenteral nutrition include postsurgical comp...
Source: Current Opinion in Gastroenterology - January 31, 2020 Category: Gastroenterology Tags: NUTRITION: Edited by Eamonn M.M. Quigley Source Type: research

An autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report
ConclusionThis case represents a  unique autoimmune paraneoplastic neurologic syndrome, likely specific to neuroendocrine tumors and motivated by concurrent radioimmunotherapy. Recognition of the potential role of radioimmunotherapy may provide an advantage in anticipating these severe sequelae. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - January 31, 2020 Category: Cancer & Oncology Source Type: research

Front Cover
The cover image is based on the Case ReportAutonomic and peripheral neuropathy with reduced intraepidermal nerve fiber density can be observed in patients with gastrointestinal dysmotility by Bodil Ohlsson, B éla Veress, LARS B DAHLIN et al.,https://doi.org/10.1002/ccr3.2575. (Source: Clinical Case Reports)
Source: Clinical Case Reports - January 29, 2020 Category: General Medicine Authors: Bodil Ohlsson, Lars B. Dahlin, Elisabet Englund, B éla Veress Tags: FRONT COVER Source Type: research

Use of Catheter Lock Solutions in Patients Receiving Home Parenteral Nutrition: A Systematic Review and Individual-Patient Data Meta-analysis.
Abstract BACKGROUND: Use of catheter lock solutions (CLSs) as a strategy to prevent catheter-related bloodstream infections (CRBSIs) has been evaluated in recent clinical trials. Our aim was to identify the most effective CLS formulation in patients receiving home parenteral nutrition (HPN). METHODS: We conducted a systematic review and individual-patient data meta-analysis (IPDMA). Prospective randomized clinical trials in adult HPN patients using CLS were identified from PubMed, EMBASE, Web of Science, CINAHL, Cochrane library, and ClinicalTrials.gov. Primary outcome was the number of CRBSIs per 1000 cathet...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - January 27, 2020 Category: Nutrition Authors: Wouters Y, Causevic E, Klek S, Groenewoud H, Wanten GJA Tags: JPEN J Parenter Enteral Nutr Source Type: research

Gastrointestinal Dysfunction and Feeding Intolerance in Critical Illness: Do We Need an Objective Scoring System?
AbstractPurpose of ReviewEfforts to provide early enteral nutrition in critical illness are thwarted by gastrointestinal dysfunction and feeding intolerance. While many of the signs and symptoms of this dysfunction reflect gastroparesis and intestinal dysmotility, other symptoms which may or may not be related are often included such as diarrhea, bleeding, and intra-abdominal hypertension. This paper discusses the need to monitor tolerance of nutritional therapy in the critical care setting and reviews the results of those clinical trials which have helped establish objective measures, define feeding intolerance, and provi...
Source: Current Gastroenterology Reports - January 7, 2020 Category: Gastroenterology Source Type: research

Subtotal colectomy and ileorectal anastomosis for slow transit constipation: clinical follow-up at median of 15  years
We present a follow-up study of the long-term function in patients who had surgery for laxative-resistant slow transit constipation.MethodsA postal survey was sent to assess bowel frequency, abdominal pain, St Mark ’s continence score, satisfaction with procedure, likelihood to choose the procedure again, and long-term rates of small bowel obstruction and ileostomy. Longitudinal data from a subgroup studied 23 years previously are reported.ResultsForty-two patients (male = 2) were available for follow-up out of an initial cohort of 102. Mean time since surgery was 15.9 years (range 1.7–2...
Source: Techniques in Coloproctology - January 6, 2020 Category: Surgery Source Type: research

No Gastrointestinal Dysmotility in Transgenic Mouse Models of Migraine.
CONCLUSIONS: We detected no evidence of upper gastrointestinal dysmotility in mice that express mutations in genes linked to monogenic migraine-relevant phenotypes. Future studies seeking to understand why humans with migraine experience delayed gastric emptying may benefit from pursuing other modifiers of gastrointestinal motility, such as epigenetic or microbiome-related factors. PMID: 31876298 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - December 26, 2019 Category: Neurology Authors: Sprouse Blum AS, Lavoie B, Haag M, Mawe SM, Tolner EA, van den Maagdenberg AMJM, Chen SP, Eikermann-Haerter K, Ptáček L, Mawe GM, Shapiro RE Tags: Headache Source Type: research

Esophageal dysmotility and other preoperative factors associated with acid suppressive therapy after fundoplication.
Authors: Rouphael C, Shakya S, Arora Z, Gabbard S, Rice T, Lopez R, Raja S, Murthy S, Thota PN Abstract Background and aims: Acid suppressive therapy (AST) is frequently used after fundoplication. Prior studies show that most patients requiring AST after fundoplication have normal esophageal acid exposure and therefore do not need AST. Our aim was to determine the indications for AST use following fundoplication and the associated factors.Methods: Retrospective analysis of patients who underwent fundoplication at our institution between 2006 and 2013 with pre and postoperative esophageal physiologic studies was per...
Source: Scandinavian Journal of Gastroenterology - December 21, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Ameliorating Effects and Autonomic Mechanisms of Transcutaneous Electrical Acustimulation in Patients With Gastroesophageal Reflux Disease
ConclusionsAcute TEA increases gastric accommodation, improves gastric slow waves, and reduces postprandial fullness and belching, possibly mediated via the vagal mechanisms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 20, 2019 Category: Biotechnology Authors: Yedong Hu, Bo Zhang, Xiaodan Shi, Beifang Ning, Jian Shi, Xin Zeng, Fei Liu, Jiande DZ Chen, Wei ‐Fen Xie Tags: Clinical Research Source Type: research

Pulmonary capillary hemangiomatosis or hepatopulmonary syndrome in a patient with calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia syndrome?
PMID: 31868804 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 20, 2019 Category: General Medicine Authors: Shrestha BL, Jin YK Tags: Chin Med J (Engl) Source Type: research

Upregulation of gastric norepinephrine with beta-adrenoceptors and gastric dysmotility in a rat model of functional dyspepsia.
In conclusion, the enhanced NE and beta-adrenoceptors and NETs may be contributed to the disordered gastric motility in FD rats. PMID: 31852208 [PubMed - as supplied by publisher] (Source: Physiological Research)
Source: Physiological Research - December 19, 2019 Category: Physiology Authors: Song J, Wang T, Zhang X, Li B, Zhang S Tags: Physiol Res Source Type: research

Feeding Tolerance, Intestinal Motility, and Superior Mesenteric Artery Blood Flow in Infants with Gastroschisis.
CONCLUSION: Increased SMA blood flow at the time of abdominal wall closure is positively correlated with feeding tolerance, suggesting the importance of initial intestinal perfusion in the pathophysiology for feeding intolerance and intestinal dysmotility in gastroschisis. PMID: 31851996 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - December 18, 2019 Category: Perinatology & Neonatology Authors: Williams SL, Tkach JA, Rattan MS, South AP, Wessel J, Kingma PS Tags: Neonatology Source Type: research

Pediatric Intestinal Pseudo-obstruction in the Era of Genetic Sequencing
AbstractPurpose of ReviewThe purpose of this review is to discuss current knowledge on pediatric intestinal pseudo-obstruction. We will also review new mutations that have been identified through advancement in genetic testing, allowing for a better understanding of the underlying mechanisms of intestinal dysmotility and potential etiologies.Recent FindingsWith the advancements in genetic testing, new mutations have been identified in the diagnosis of megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS), a disorder leading to pediatric pseudo-obstruction. MYLK, LMOD1, MYL9, and MYH11 encode for various protein...
Source: Current Gastroenterology Reports - December 17, 2019 Category: Gastroenterology Source Type: research

Efficacy and Safety of Ghrelin Agonists in Patients with Diabetic Gastroparesis: A Systematic Review and Meta-Analysis.
Conclusions: Compared with placebo, ghrelin agonists are effective and well-tolerated for the treatment of DG. PMID: 31816671 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - December 11, 2019 Category: Gastroenterology Tags: Gut Liver Source Type: research

Gastrointestinal Motility Issues in Cancer Patients
AbstractPurpose of ReviewThis paper seeks to highlight GI motility disorders that are frequently present in patients with a malignancy. GI dysmotility can occur due to the cancer itself or as a consequence of medical and surgical treatments. Often, symptoms are nonspecific and the diagnosis requires a high index of suspicion. The goal of the paper is to review the common motility problems seen in patients with cancer, their clinical manifestations, and options for management.Recent FindingsStudies show that newer endoscopy techniques such as endoscopic mucosal dissection can cause esophageal dysmotility. Opioid-induced con...
Source: Current Gastroenterology Reports - December 10, 2019 Category: Gastroenterology Source Type: research

Proximal and Distal Gastric Retention Patterns in Gastroparesis and the Impact of Gastric Per Oral Endoscopic Myotomy: a retrospective Analysis Using Gastric Emptying Scintigraphy.
Authors: Spnadorfer R, Zhu Y, Mekaroonkamol P, Dacha S, Galt J, Halkar R, Cai Q Abstract Introduction: Gastroparesis is a debilitating disease of insufficient gastric emptying and visceral hypersensitivity characterized by nausea, vomiting, early satiety and bloating. Gastric emptying scintigraphy (GES), in combination with typical symptoms and normal esophagogastroduodenoscopy, is used to diagnose the disease. Gastric per-oral endoscopic pyloromyotomy (G-POEM or POP) has emerged as a novel technique for treating gastroparesis with up to 80% success rate. This procedure involves a myotomy of the distal stomach. We ...
Source: Journal of Nuclear Medicine Technology - December 9, 2019 Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research

Autonomic and peripheral neuropathy with reduced intraepidermal nerve fiber density can be observed in patients with gastrointestinal dysmotility
Neuropathy should be considered as a possible etiological factor in patients with severe gastrointestinal symptoms, without signs of disease on routine investigations. Examinations of the autonomic and peripheral nervous systems may be helpful to select the patients who should be investigated with full ‐thickness intestinal biopsy, and to give appropriate care. AbstractNeuropathy should be considered as a possible etiological factor in patients with severe gastrointestinal symptoms, without signs of disease on routine investigations. Examinations of the autonomic and peripheral nervous systems may be helpful to select th...
Source: Clinical Case Reports - December 4, 2019 Category: General Medicine Authors: Bodil Ohlsson, Lars B. Dahlin, Elisabet Englund, B éla Veress Tags: CASE REPORT Source Type: research

Correlations between Depressive Condition and Gastroesophageal Reflux Symptoms in Patients Visiting a Department of General Medicine.
Abstract To clarify the potential relevance of patients' chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), orthopedic and skin (10%), and systemic (22%) symptoms. The SDS score tended to be higher in females and younger...
Source: Acta Med Okayama - December 1, 2019 Category: Universities & Medical Training Authors: Suganami Y, Oka K, Hanayama Y, Honda H, Hamahara J, Obika M, Kariyama K, Kishida M, Otsuka F Tags: Acta Med Okayama Source Type: research

Prediction & management of respiratory co-morbidities following congenital tracheoesophageal fistula repair: a multidisciplinary approach
Conclusions: The presence of oesophageal co-morbidities is associated with symptomatic respiratory co-morbidities. These appear to present prior to respiratory co-morbidities & can be used as a predictor of the onset of respiratory morbidity. Prospective validation of the score should be undertaken. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: King, G., Bhatt, J. M., Bolton, M., Locke, L., Croft, K., Motiwale, S. S., Davies, B. W. Tags: Paediatric respiratory infection and immun. Source Type: research

The role of high-resolution manometry in the assessment of upper gastrointestinal involvement in systemic sclerosis: a systematic review
The objectives of this systematic review were to investigate the role of HRM in the assessment of SSc-associated upper GI involvement and to evaluate the correlation between HRM abnormalities and clinical characteristics and the effects of therapeutic interventions on HRM findings. Fifteen articles were included. Most (11/15) studies were of very good or good quality. Most studies assessed correlations between esophageal symptoms and esophageal dysmotility. Two studies assessed the effectiveness of buspirone and reported HRM findings. Studies assessing upper GI symptoms using validated questionnaires, such as the Universit...
Source: Clinical Rheumatology - November 11, 2019 Category: Rheumatology Source Type: research

Diabetic Gastroenteropathy: A Complication of Diabetes Mellitus.
Authors: Kurniawan AH, Suwandi BH, Kholili U Abstract Diabetic gastroenteropathy is a common complication in prolonged diabetic patients, particularly patients with poor glycemic control or other complications, including all form of diabetic complication on the gastrointestinal tract, which prompts various symptoms of heartburn, abdominal pain, nausea, vomiting, even constipation, diarrhea, and fecal incontinence. The underlying pathophysiology of this complication manifestations are different on each organ or symptom, but may include autonomic nervous system neuropathy, loss of Interstitial Cell of Cajal as gastri...
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Oesophageal atresia and tracheo-oesophageal fistula
Publication date: Available online 22 October 2019Source: Surgery (Oxford)Author(s): Spencer W. BeasleyAbstractOesophageal atresia and tracheo-oesophageal fistula is a congenital structural abnormality that affects 1:4500 live infants. It is due to failure of the primitive foregut tube to separate correctly into oesophagus and trachea. About 50% have associated abnormalities, of which the VACTERL (Vertebral, Anorectal, Cardiac, Tracheo-oEsophageal, Renal and Limb) association is the most common. Prematurity is common and all have some degree of tracheomalacia. Surgery of the common type can be performed through a fourth in...
Source: Surgery (Oxford) - October 23, 2019 Category: Surgery Source Type: research

Staining of antinuclear antibodies and antibodies against removable nuclear antigens in connective tissue diseases.
-Huarcaya L Abstract INTRODUCTION AND OBJECTIVES: Connective tissue diseases are inflammatory, autoimmune diseases and threaten quality of life. To determine the relationship between staining patterns of antinuclear antibodies and antibodies against extractable nuclear antigens in patients with connective tissue disease. MATERIALS AND METHODS: Observational, basic, analytical and transversal study. Study conducted in the Immunology Service of the Arzobispo Loayza National Hospital between January 2017 and June 2017. We analyzed 291 samples of patients with CTD and for the detection of anti-nuclear antibody st...
Source: Allergologia et Immunopathologia - October 14, 2019 Category: Allergy & Immunology Authors: OlivaMenacho JE, Arroyo-Acevedo JL, Oliva-Candela JA, García-Hjarles MA, Domínguez-Huarcaya L Tags: Allergol Immunopathol (Madr) Source Type: research

Enteric neuroplasticity and dysmotility in inflammatory disease: key players and possible therapeutic targets.
Abstract Intestinal functions, including motility and secretion, are locally controlled by enteric neural networks housed within the wall of the gut. The fidelity of these functions depends on the precision of intercellular signaling amongst cellular elements, including enteric neurons, epithelial cells, immune cells, and glia, all of which are vulnerable to disruptive influences during inflammatory events. This review article describes current knowledge regarding inflammation-induced neuroplasticity along key elements of enteric neural circuits, what is known about the causes of these changes, and possible therap...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 11, 2019 Category: Physiology Authors: Spear ET, Mawe GM Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Intranasal Administration of Oxytocin Attenuates Stress Responses Following Chronic Complicated Stress in Rats.
Conclusion: Intranasal administration of OXT has an anxiolytic effect and attenuates the hypothalamus-pituitary-adrenal axis in response to CCS, and gave effects which helped to restore GI dysmotility, and might be a new approach for the treatment of stress-induced GI motility disorders. PMID: 31587552 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Effects of Naloxegol on Gastrointestinal Transit and Colonic Fecal Volume in Healthy Participants Receiving Oxycodone.
Authors: Olesen AE, Grønlund D, Mark EB, Krogh K, Frøkjær JB, Drewes AM Abstract Background/Aims: Opioids cause gastrointestinal (GI) dysmotility, decrease gut secretion, and affect gut sphincters. Symptoms of opioid-induced bowel dysfunction may be alleviated by peripherally acting opioid antagonists like naloxegol, but detailed knowledge on GI effects of this drug is lacking. We hypothesized that naloxegol, compared to placebo, would reduce GI transit time and colonic fecal volume in opioid-treated healthy participants. Methods: We conducted a randomized, double-blinded, single-center, 2-w...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells.
Conclusion: Colonic transit disorder may be due to the downregulation of the Kit and Ano1 channels and the upregulation of SK3 channels in platelet-derived growth factor receptor-α positive (PDGFRα+) cells. The imbalance between interstitial cells of Cajal-Ano1 and PDGFRαSK3 distribution might be a potential reason for the colonic dysmotility. PMID: 31587550 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review.
Authors: Nardo GD, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Cal G, Giorgio R Abstract Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is usually clinical and diagnostic work is usually aimed to rule out mechanical obstruction and to identify any underlying diseases. Treatment is challenging and requires a multidisciplinary effort. In this manuscript we describe the youngest child successfully treated with ...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Management of the Patient with Chronic Intestinal Pseudo-Obstruction and Intestinal Failure
Chronic intestinal pseudo-obstruction (CIPO) is a severe form of intestinal dysmotility disorder, characterized by the impairment of gastrointestinal propulsion of the gut content in the absence of fixed occluding lesions. CIPO is a rare disease that can develop in both children and adults. CIPO is classified as primary/idiopathic, when no underlying disorder is demonstrated, or secondary, when related to systemic diseases. Diagnosis relies on the finding of chronic/recurrent obstructive type symptoms with radiological features of dilated intestine with air/fluid levels without any lumen occluding lesion. Therapy is based ...
Source: Gastroenterology Clinics of North America - October 8, 2019 Category: Gastroenterology Authors: Loris Pironi, Anna Simona Sasdelli Source Type: research

Generating an Artificial Intestine for the Treatment of Short Bowel Syndrome
Intestinal failure is defined as the inability to maintain fluid, nutrition, energy, and micronutrient balance that leads to the inability to gain or maintain weight, resulting in malnutrition and dehydration. Causes of intestinal failure include short bowel syndrome (ie, the physical loss of intestinal surface area and severe intestinal dysmotility). For patients with intestinal failure who fail to achieve enteral autonomy through intestinal rehabilitation programs, the current treatment options are expensive and associated with severe complications. Therefore, the need persists for next-generation therapies, including ce...
Source: Gastroenterology Clinics of North America - October 4, 2019 Category: Gastroenterology Authors: Mark L. Kovler, David J. Hackam Source Type: research

Mechanism of CNP-mediated DG-PKC and IP4 signaling pathway in diabetic rats with gastric motility disorder.
Abstract In the precedent research conducted by the same team, it concluded that the activities in C-type natriuretic peptide (CNP)/cyclic guanosine monophosphate (cGMP)/cyclic adenosine monophosphate (cAMP)/β-type phospholipase C (PLCβ) pathways of rat antral smooth muscle were changed due to diabetes, which was the key pathogenetic mechanism for diabetic gastric dysmotility. As the follow-on step, this study was designed to probe into the downstream signaling pathway of CNP/PLCβ. The results showed that level of α-type protein kinase C (PKCα),cell membrane to cytoplasm ratio of PKC&alp...
Source: Molecular Biology Reports - October 3, 2019 Category: Molecular Biology Authors: Lian HM, Guo JY, Sun Y, Zhang MH, Piao LH, Jin Z, Cai YL Tags: Mol Biol Rep Source Type: research