GSE229320 The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]
Contributor : Christoph A ThaissSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), where psychological stress is associated with disease flares. Here, we discover a critical role for the enteric nervous system (ENS) in mediating the aggravating effect of chronic stress on intestinal inflammation. We find that chronically elevated levels of glucocorticoids drive the generation of an inflammatory subset of enteric glia that promotes monocyte- and TNF-media...
Source: GEO: Gene Expression Omnibus - May 25, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Knockdown of miR ‐19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression
ConclusionKnockdown of miR-19a inhibits activation of the VIP –NO–cGMP–PKG pathway through suppression of VIP expression, which in turn inhibits diarrhea after TBI. (Source: Brain and Behavior)
Source: Brain and Behavior - May 23, 2023 Category: Neurology Authors: Ying An,
Sheng Hu,
Yu Zhang,
Zhengji Song,
Ruochang Li,
Yan Li,
Yongli Li,
Wenjun Ren,
Ping Wan Tags: ORIGINAL ARTICLE Source Type: research
The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility
Channels (Austin). 2023 Dec;17(1):2212350. doi: 10.1080/19336950.2023.2212350.ABSTRACTThe Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel II neurons in enteric nervous system. The small diameter neurons in dorsal root ganglions are the primary sensory neurons of pain conduction. Nav1.9 channels also participate in regulating intestinal motility. Functional enhancements of Nav1.9 channels to a certain extent lead to hyperexc...
Source: Channels - May 15, 2023 Category: Molecular Biology Authors: Chenyu Zhao Xi Zhou Xiaoliu Shi Source Type: research
The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility
Channels (Austin). 2023 Dec;17(1):2212350. doi: 10.1080/19336950.2023.2212350.ABSTRACTThe Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel II neurons in enteric nervous system. The small diameter neurons in dorsal root ganglions are the primary sensory neurons of pain conduction. Nav1.9 channels also participate in regulating intestinal motility. Functional enhancements of Nav1.9 channels to a certain extent lead to hyperexc...
Source: Channels - May 15, 2023 Category: Molecular Biology Authors: Chenyu Zhao Xi Zhou Xiaoliu Shi Source Type: research
Comprehensive Manometric Evaluation of Dysphagia in Patients with Down Syndrome
AbstractDysphagia is a common symptom in children with Down syndrome and is conventionally evaluated with imaging and endoscopy; high-resolution manometry is not routinely utilized. The aim of this study was to describe and correlate pharyngeal and esophageal manometry findings with contrast studies and endoscopy in patients with Down syndrome and dysphagia. Electronic medical records of patients with Down syndrome with dysphagia seen at our center between January 2008 and January 2022 were reviewed. Data collected included demographics, co-morbidities, symptoms, imaging, endoscopy, and manometry. Twenty-four patients with...
Source: Dysphagia - May 12, 2023 Category: Speech-Language Pathology Source Type: research
Gut dysmotility in children with neurological impairment: the nutritional management
Intestinal motility disorders represent a frequent problem in children with neurological impairment. These conditions are characterized by abnormal movements of the gut, which can result in symptoms such as constipation, diarrhea, reflux, and vomiting. The underlying mechanisms leading to dysmotility are various, and the clinical manifestations are often nonspecific. Nutritional management is an important aspect of care for children with gut dysmotility, as it can help to improve their quality of life. Oral feeding, when safe and in the absence of risk of ingestion or severe dysphagia, should always be encouraged. When ora...
Source: Frontiers in Neurology - May 5, 2023 Category: Neurology Source Type: research
Tracking Gut Motility in Organ and Cultures
Methods Mol Biol. 2023;2644:449-466. doi: 10.1007/978-1-0716-3052-5_29.ABSTRACTGastrointestinal (GI) motility is a key component of digestive health, and it is complex, involving a multitude of cell types and mechanisms to drive both rhythmic and arrhythmic activity. Tracking GI motility in organ and tissue cultures across multiple temporal (seconds, minutes, hours, days) scales can provide valuable information regarding dysmotility and to evaluate treatment options. Here, the chapter describes a simple method to monitor GI motility in organotypic cultures, using a single video camera is placed perpendicularly to the surfa...
Source: Mol Biol Cell - May 4, 2023 Category: Molecular Biology Authors: Peng Du Vikram Joshi Arthur Beyder Source Type: research
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility
Dysmotility and postoperative ileus (POI) are frequent major clinical problems post-abdominal surgery. Erythropoietin (EPO) is a multifunctional tissue-protective cytokine that promotes recovery of the intesti... (Source: BMC Biotechnology)
Source: BMC Biotechnology - May 1, 2023 Category: Biotechnology Authors: Prem Kumar Govindappa, Mosammat Begom, Yash Gupta, John C. Elfar, Manmeet Rawat and Walaa Elfar Tags: Research Source Type: research
A Case of Rapid and Unexpected Esophageal Dysmotility
Swallowing is an important yet complex function that is affected by normal aging as well as processes of structural, neurological, or infectious etiologies. Dysphagia can affect any level of swallowing (oropharyngeal or esophageal) and early recognition and management are important for the nutrition, safety and overall care of the older adult in post-acute and long-term care (PALTC) settings. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - April 28, 2023 Category: Health Management Authors: Sara Shu, Paul Takahashi, Jennifer Pecina Tags: Poster Abstract Source Type: research
Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury
AbstractOrgan crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a two-way pathway. The communication between the central nervous system and peripheral organs involves nerves, endocrine, and immunity systems as well as the emotional and cognitive centers of the brain. Particularly, acute brain injury is complicated by neuroinflammation and neurodegeneration causing multiorgan inflammation, microbial dysbiosis, gastrointestinal dysfunction and dysmotility, liver dysfunction, acute kidney injury, and cardiac dysfunction. Organ crosstalk ha...
Source: Neurocritical Care - April 20, 2023 Category: Neurology Source Type: research
Non-acid reflux and esophageal dysmotility is associated with early esophageal squamous cell carcinoma
CONCLUSION: Our study found NAR and esophageal dysfunction frequently occur in ESCC patients. NAR and esophageal dysmotility may be associated with ESCC.CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR2200061456.PMID:37074455 | DOI:10.1007/s00432-023-04772-5 (Source: Cell Research)
Source: Cell Research - April 19, 2023 Category: Cytology Authors: Yujie Hao Mo Wang Xiaosa Jiang Yueqin Zheng Qiuju Ran Xiaoyu Xu Baicang Zou Jinhai Wang Na Liu Bin Qin Source Type: research
Functional outcome of Hirschsprung's disease in children: A single center study at The Children's Hospital Lahore
ConclusionOn long-term follow-up, fecal incontinence was more worrisome, affecting quality of life and requiring help of the bowel management program. Such patients need close follow-up after definitive procedure, so that they have normal stooling habits in their adulthood and lead a normal life. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - April 11, 2023 Category: Surgery Source Type: research
Acute exposure of Isopyrazam damages the developed cardiovascular system of zebrafish (Danio rerio)
J Environ Sci Health B. 2023 Apr 9:1-11. doi: 10.1080/03601234.2023.2197655. Online ahead of print.ABSTRACTIsopyrazam (IPZ) is one of the broad-spectrum succinate dehydrogenase inhibitor fungicides (SDHIs). Although the potential bio-toxicity of SDHIs has been reported hourly, the specific effects focused on the cardiovascular system have remained unclear and piecemeal. Thus, we chose IPZ as a representative to observe the cardiovascular toxicity of SDHIs in zebrafish. Two types of transgenic zebrafish, Tg (cmlc2:GFP) and Tg (flk1:GFP) were used in this study. Healthy embryos at 6 hpf were exposed to IPZ solutions. The sta...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - April 10, 2023 Category: Environmental Health Authors: Yuepei Yan Shuang Liang Tao Zhang Chengchen Deng Huili Li Dechuan Zhang Daoxi Lei Guixue Wang Source Type: research
Acute exposure of Isopyrazam damages the developed cardiovascular system of zebrafish (Danio rerio)
J Environ Sci Health B. 2023 Apr 9:1-11. doi: 10.1080/03601234.2023.2197655. Online ahead of print.ABSTRACTIsopyrazam (IPZ) is one of the broad-spectrum succinate dehydrogenase inhibitor fungicides (SDHIs). Although the potential bio-toxicity of SDHIs has been reported hourly, the specific effects focused on the cardiovascular system have remained unclear and piecemeal. Thus, we chose IPZ as a representative to observe the cardiovascular toxicity of SDHIs in zebrafish. Two types of transgenic zebrafish, Tg (cmlc2:GFP) and Tg (flk1:GFP) were used in this study. Healthy embryos at 6 hpf were exposed to IPZ solutions. The sta...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - April 10, 2023 Category: Environmental Health Authors: Yuepei Yan Shuang Liang Tao Zhang Chengchen Deng Huili Li Dechuan Zhang Daoxi Lei Guixue Wang Source Type: research
