Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice
CONCLUSIONS: These results suggest that the direct stimulation by VCR increases the mesenteric afferent sensitivity by activating TRPV1, which may be the reason of VCR-induced abdominal pain; the long-term systemic treatment of VCR decreases mesenteric afferent sensitivity by reducing TRPV1, which may be the reason of VCR-induced constipation.PMID:38458354 | DOI:10.1016/j.taap.2024.116887 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 8, 2024 Category: Toxicology Authors: Shuang Li Mengyuan Yang Yao Shi Jingxin Li Chuanyong Liu Source Type: research
Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice
CONCLUSIONS: These results suggest that the direct stimulation by VCR increases the mesenteric afferent sensitivity by activating TRPV1, which may be the reason of VCR-induced abdominal pain; the long-term systemic treatment of VCR decreases mesenteric afferent sensitivity by reducing TRPV1, which may be the reason of VCR-induced constipation.PMID:38458354 | DOI:10.1016/j.taap.2024.116887 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 8, 2024 Category: Toxicology Authors: Shuang Li Mengyuan Yang Yao Shi Jingxin Li Chuanyong Liu Source Type: research
Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice
CONCLUSIONS: These results suggest that the direct stimulation by VCR increases the mesenteric afferent sensitivity by activating TRPV1, which may be the reason of VCR-induced abdominal pain; the long-term systemic treatment of VCR decreases mesenteric afferent sensitivity by reducing TRPV1, which may be the reason of VCR-induced constipation.PMID:38458354 | DOI:10.1016/j.taap.2024.116887 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 8, 2024 Category: Toxicology Authors: Shuang Li Mengyuan Yang Yao Shi Jingxin Li Chuanyong Liu Source Type: research
Role of autoantibodies in the pathophysiology of irritable bowel syndrome: a review
Irritable bowel syndrome (IBS) is a chronic, recurrent disorder that is characterized by abdominal pain associated with defecation. IBS was previously considered to manifest without any structural alterations until the discovery of post-infection IBS. An increasing body of published evidence indicates that immune activation plays an important role in the development of IBS. Nevertheless, the pathophysiology of IBS, including mainly visceral hypersensitivity and gastrointestinal dysmotility, has not yet been explicitly elucidated. The observation of potential inflammatory degenerative neuropathy, including neuronal degenera...
Source: Frontiers in Physiology - March 5, 2024 Category: Physiology Source Type: research
MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3 β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis
In conclusion, this study indicated that miR-26b-3p promotes intestinal motility disorders by targeting FZD10 to block GSK3β/β-catenin signaling and induces apoptosis in EGCs. Our results provide a new research target for the treatment and intervention of intestinal dysmoti lity. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - March 1, 2024 Category: Neurology Source Type: research
Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal Encephalopathy Syndrome: A Case Report
CONCLUSIONS This is the first reported case of mitochondrial neurogastrointestinal encephalomyopathy to undergo successful sequential liver and intestine transplantation.PMID:38409779 | DOI:10.12659/AOT.941881 (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Chandrashekhar A Kubal Plamen Mihaylov Riley Snook Daiki Soma Omer Saeed Zachary Rokop Marco Lacerda Brett H Graham Richard S Mangus Source Type: research
Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal Encephalopathy Syndrome: A Case Report
CONCLUSIONS This is the first reported case of mitochondrial neurogastrointestinal encephalomyopathy to undergo successful sequential liver and intestine transplantation.PMID:38409779 | DOI:10.12659/AOT.941881 (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Chandrashekhar A Kubal Plamen Mihaylov Riley Snook Daiki Soma Omer Saeed Zachary Rokop Marco Lacerda Brett H Graham Richard S Mangus Source Type: research
Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal Encephalopathy Syndrome: A Case Report
CONCLUSIONS This is the first reported case of mitochondrial neurogastrointestinal encephalomyopathy to undergo successful sequential liver and intestine transplantation.PMID:38409779 | DOI:10.12659/AOT.941881 (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Chandrashekhar A Kubal Plamen Mihaylov Riley Snook Daiki Soma Omer Saeed Zachary Rokop Marco Lacerda Brett H Graham Richard S Mangus Source Type: research
Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal Encephalopathy Syndrome: A Case Report
CONCLUSIONS This is the first reported case of mitochondrial neurogastrointestinal encephalomyopathy to undergo successful sequential liver and intestine transplantation.PMID:38409779 | DOI:10.12659/AOT.941881 (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Chandrashekhar A Kubal Plamen Mihaylov Riley Snook Daiki Soma Omer Saeed Zachary Rokop Marco Lacerda Brett H Graham Richard S Mangus Source Type: research
Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal Encephalopathy Syndrome: A Case Report
CONCLUSIONS This is the first reported case of mitochondrial neurogastrointestinal encephalomyopathy to undergo successful sequential liver and intestine transplantation.PMID:38409779 | PMC:PMC10908187 | DOI:10.12659/AOT.941881 (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Chandrashekhar A Kubal Plamen Mihaylov Riley Snook Daiki Soma Omer Saeed Zachary Rokop Marco Lacerda Brett H Graham Richard S Mangus Source Type: research
Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal Encephalopathy Syndrome: A Case Report
CONCLUSIONS This is the first reported case of mitochondrial neurogastrointestinal encephalomyopathy to undergo successful sequential liver and intestine transplantation.PMID:38409779 | PMC:PMC10908187 | DOI:10.12659/AOT.941881 (Source: Annals of Transplantation)
Source: Annals of Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Chandrashekhar A Kubal Plamen Mihaylov Riley Snook Daiki Soma Omer Saeed Zachary Rokop Marco Lacerda Brett H Graham Richard S Mangus Source Type: research
MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3 β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis
In conclusion, this study indicated that miR-26b-3p promotes intestinal motility disorders by targeting FZD10 to block GSK3β/β-catenin signaling and induces apoptosis in EGCs. Our results provide a new research target for the treatment and intervention of intestinal dysmoti lity. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - February 27, 2024 Category: Neurology Source Type: research
Gastric, small bowel and colonic motility and breath-testing
The gastrointestinal (GI) tract is responsible for the digestion, absorption and excretion of ingested food and drink. From ingestion to excretion, movement of luminal contents is regulated by the enteric and central nervous systems, which stimulate contractions of the smooth muscle of the stomach, small intestine and colon. Dysfunction of GI motility can relate to pathology of these neural complexes or changes to the smooth muscle, or appear idiopathic. When dysmotility occurs, individuals can experience a diverse array of symptoms including abdominal symptoms, changes in bowel habit and serious consequences such as malnu...
Source: Medicine - February 24, 2024 Category: Internal Medicine Authors: Sam Treadway, Anthony Hobson Tags: Motility and functional bowel disease Source Type: research
Indications for Multivisceral Transplantation
Consensus remains elusive in the definition and indications of multivisceral transplantation (MVT) within the transplant community. MVT encompasses transplantation of all organs reliant on the celiac artery axis and the superior mesenteric artery in different combinations. Some institutions classify MVT as involving the grafting of the stomach or ascending colon in addition to the jejunoileal complex. MVT indications span a wide spectrum of conditions, including tumors, intestinal dysmotility disorders, and trauma. This systematic review aims to consolidate existing literature on MVT cases and their indications, providing ...
Source: Gastroenterology Clinics of North America - February 8, 2024 Category: Gastroenterology Authors: Pierpaolo Di Cocco, Alessandro Martinino, Amy Lian, Jess Johnson, Mario Spaggiari, Ivo Tzvetanov, Enrico Benedetti Source Type: research
Artificial Intelligence Tools for Improving Manometric Diagnosis of Esophageal Dysmotility
AbstractPurpose of ReviewArtificial intelligence (AI) is a broad term that pertains to a computer ’s ability to mimic and sometimes surpass human intelligence in interpretation of large datasets. The adoption of AI in gastrointestinal motility has been slower compared to other areas such as polyp detection and interpretation of histopathology.Recent FindingsWithin esophageal physiologic testing, AI can automate interpretation of image-based tests, especially high resolution manometry (HRM) and functional luminal imaging probe (FLIP) studies. Basic tasks such as identification of landmarks, determining adequacy of the HRM...
Source: Current Gastroenterology Reports - February 7, 2024 Category: Gastroenterology Source Type: research
