Downregulation of mesenteric afferent sensitivity following long-term systemic treatment of vincristine in mice

CONCLUSIONS: These results suggest that the direct stimulation by VCR increases the mesenteric afferent sensitivity by activating TRPV1, which may be the reason of VCR-induced abdominal pain; the long-term systemic treatment of VCR decreases mesenteric afferent sensitivity by reducing TRPV1, which may be the reason of VCR-induced constipation.PMID:38458354 | DOI:10.1016/j.taap.2024.116887

Source: Toxicology and Applied Pharmacology - March 8, 2024 Category: Toxicology Authors: Shuang Li Mengyuan Yang Yao Shi Jingxin Li Chuanyong Liu Source Type: research