How is Endometriosis Diagnosed?
Discussion Endometriosis is classically defined as endometrial tissue occurring outside the uterine lining. It is a common cause of chronic pelvic pain and dysmenorrhea in adolescents. It can present differently in adolescents than adult women and usually can appear like many other common problems such as chronic constipation or gastrointestinal dysmotility. It is estimated that ~25-38% of adolescents with chronic pelvic pain have endometriosis. Use of clinical criteria versus laparoscopic documentation of disease makes the epidemiology of this problem more challenging. The cause is not wholly agreed upon but many believe ...
Source: - November 28, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Statins: The cholesterol-lowering drug could cause 'bowel dysmotility' - what to look for
STATIN therapy has become ubiquitous, but when side effects drastically affect a patient's quality of life, they may ultimately impact their compliance. According to early research, bowel dysmotility may be a lesser-known aftereffect linked to a wide range of symptoms. (Source: Daily Express - Health)
Source: Daily Express - Health - May 10, 2022 Category: Consumer Health News Source Type: news

What is Refeeding Syndrome?
Discussion Anorexia nervosa is an eating disorder with an intense fear of being overweight (i.e. distorted body image), and self-starvation and excessive weight loss. It is more common in women (1.2%) than men (0.2%) but can be seen in both genders. Risk factors include high-intelligence, perfectionism/inflexibility, anxiety, activities where thinner body types are expected (e.g. dancer, diver, gymnast, long-distance runner, volleyball player, etc.) Other eating disorders include bulimia nervosa (i.e. cycles of binge eating and then purging), binge eating disorder (i.e. purging), orthorexia (i.e. obsessions with healthful ...
Source: - October 25, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Japanese-European research team discovers novel genetic mitochondrial disorder
(Fujita Health University) The list of known genetic mitochondrial disorders is ever-growing, and ongoing research continues to identify new disorders in this category. In an article recently published in Brain, a Japanese-European team of scientists, including researchers from Fujita Health University, describe mutations in the LIG3 gene, which plays a crucial role in mitochondrial DNA replication. These mutations cause a previously unknown syndrome characterized by gut dysmotility, leukoencephalopathy, and neuromuscular abnormalities. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2021 Category: International Medicine & Public Health Source Type: news

Autonomic function, postprandial hypotension and falls in older adults at one year after critical illness - Ali Abdelhamid Y, Weinel LM, Hatzinikolas S, Summers M, Nguyen TAN, Kar P, Phillips LK, Horowitz M, Deane AM, Jones KL.
OBJECTIVE: Postprandial hypotension occurs frequently in older survivors of critical illness at 3 months after discharge. We aimed to determine whether postprandial hypotension and its predictors - gastric dysmotility and cardiovascular autonomic dysfuncti... (Source: SafetyLit)
Source: SafetyLit - February 29, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

E-Motion Medical wins CE Mark for acute digestive dysmotility stimulator
E-Motion Medical said yesterday that it won CE Mark approval in the European Union for its E-Motion stimulation therapy system intended to treat patients with acute gastrointestinal dysmotility. The Israel-based company said that the E-Motion system is designed to deliver “unique patterns” of electrical stimulation to the esophagus using its E-Motion tube, which is placed in the same manner as a regular feeding tube. Stimulation from the newly cleared system generates contractions in the esophagus to restore natural function to the digestive system and to promote motility through the gastrointestinal tract, E-M...
Source: Mass Device - November 21, 2018 Category: Medical Devices Authors: Fink Densford Tags: Otolaryngology Ear, Nose & Throat Regulatory/Compliance emotionmedical Source Type: news

E-Motion Medical Receives CE Mark Approval for Its Novel Stimulation Therapy for Patients With Acute Digestive Dysmotility
TEL AVIV, Israel, Nov. 20, 2018 -- (Healthcare Sales & Marketing Network) -- E-Motion Medical Ltd. announced today it has received CE Mark approval for its lead product, the E-Motion System™, providing stimulation therapy that restores the natural motor f... Devices, Gastroenterology, Regulatory E-Motion Medical, E-Motion System, E-Motion Tube, gastrointestinal dysmotility (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 20, 2018 Category: Pharmaceuticals Source Type: news

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth disease type 2A (CMT2A). We showed that MFN2 activity can be determined by Met376 and His380 interactions with Asp725 and Leu727 and controlled by PINK1 kinase–mediated phosphorylation of adjacent MFN2 Ser378. Small-molecule mimics of the peptide-peptide interface of MFN2 disrupted this interaction, allosterically activating MFN2 and promoting mitochondrial fusion. These first-in-class mitofusin agonists overcame dominant mitochondrial defects provoked in ...
Source: ScienceNOW - April 19, 2018 Category: Science Authors: Rocha, A. G., Franco, A., Krezel, A. M., Rumsey, J. M., Alberti, J. M., Knight, W. C., Biris, N., Zacharioudakis, E., Janetka, J. W., Baloh, R. H., Kitsis, R. N., Mochly-Rosen, D., Townsend, R. R., Gavathiotis, E., Dorn, G. W. Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Factors Predict Severe GI Problems in SSc (CME/CE)
(MedPage Today) -- Dysmotility in systemic sclerosis linked with myopathy, sicca symptoms, nonwhite race, and male sex (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - December 3, 2017 Category: Gastroenterology Source Type: news

When transplant isn ’t the only option
Nine-year-old Ariana Dufane is happiest when she’s tumbling, whether she’s launching herself off the ground for a cartwheel or practicing how to perform the perfect split. In that moment, the fourth-grader focuses on nothing but strength and balance, a skill she has refined, not just in gymnastics but in life. Born with intestinal pseudo-obstruction — a disorder of abnormal intestinal motility function that may cause the body to go into intestinal failure — Ariana’s first few months were spent in and out of emergency rooms. Her symptoms began with a distended belly and an inability to have a bowel movement. “I...
Source: Thrive, Children's Hospital Boston - September 18, 2017 Category: Pediatrics Authors: Emily Williams Tags: Our Patients’ Stories Boston Children's Motility and Functional Gastrointestinal Disorders Center Colorectal and Pelvic Malformation Center Intestinal and Multivisceral Transplant Program intestinal transplant Leonel Rodriguez pseudo-obstruc Source Type: news

Urine Pyrimidine Metabolite Determination by HPLC Tandem Mass Spectrometry
Pyrimidine diseases result from deficiencies in pyrimidine de novo synthesis, degradation, and salvage pathways. Enzymatic deficiencies in pyrimidine catabolism lead to mitochondrial neurogastrointestinal encephalopathy (MNGIE), pyrimidinuria, dihydropyrimidinuria, ureidopropionic aciduria, and other disorders. While MNGIE presents with gastrointestinal dysmotility, cachexia, and leukoencephalopathy, pyrimidinuria and dihydropyrimidinuria may show symptoms of epilepsy, autism, mental retardation, and dysmorphic features. The application of HPLC-MS/MS facilitates rapid screening of pyrimidine metabolites. Here we describe a...
Source: Springer protocols feed by Imaging/Radiology - November 27, 2015 Category: Radiology Source Type: news

Nutrition and Growth in Neonates Undergoing Cardiac Surgery
Growth failure is a widespread health problem in infants with congenital heart disease, specifically infants with single ventricle heart lesions, including hypoplastic left heart syndrome. Optimizing nutrition delivery for neonates undergoing cardiac surgery is challenging given environmental and physiologic barriers. Concomitant with nutrition delivery challenges, wide practice variations exist among clinicians. Malnutrition and poor growth are associated with poor wound healing, increased infection risk, prolonged hospitalizations, and long-term neurodevelopmental disability, including worse school performance. The cause...
Source: NeoReviews recent issues - March 2, 2015 Category: Pediatrics Authors: Fogg, K. L., Zyblewski, S. C. Tags: Pediatric Drug Labeling Update Articles Source Type: news

Boy, 2, allergic to all food apart from potatoes, carrots and bananas
Two-year-old Max Billingham, of Felling in Gateshead was diagnosed with food protein induced enterocolitis syndrome and dysmotility of the bowel as a baby. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2014 Category: Consumer Health News Source Type: news