Gastrointestinal dysmotility in rodent models of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 23. doi: 10.1152/ajpgi.00225.2023. Online ahead of print.ABSTRACTMultiple studies describe prodromal, non-motor dysfunctions that affect the quality of life of patients who subsequently develop Parkinson's disease (PD). These prodromal dysfunctions comprise a wide array of autonomic issues, including severe gastrointestinal (GI) motility disorders such as dysphagia, delayed gastric emptying and chronic constipation. Indeed, strong evidence from studies in humans and in animal models suggests that the GI tract and its neural, mainly vagal, connection to the central nervous s...
Source: Am J Physiol Gastroi... - January 23, 2024 Category: Gastroenterology Authors: Carolina Pellegrini R Alberto Travagli Source Type: research
Gastrointestinal dysmotility in rodent models of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 23. doi: 10.1152/ajpgi.00225.2023. Online ahead of print.ABSTRACTMultiple studies describe prodromal, non-motor dysfunctions that affect the quality of life of patients who subsequently develop Parkinson's disease (PD). These prodromal dysfunctions comprise a wide array of autonomic issues, including severe gastrointestinal (GI) motility disorders such as dysphagia, delayed gastric emptying and chronic constipation. Indeed, strong evidence from studies in humans and in animal models suggests that the GI tract and its neural, mainly vagal, connection to the central nervous s...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 23, 2024 Category: Physiology Authors: Carolina Pellegrini R Alberto Travagli Source Type: research
Outcomes of Surgical Treatment of Vaughan-Jackson Syndrome
Conclusion Although a degree of functional deficit persists after Darrach's procedure and tendon transfer for treatment of VJS, there are also high levels of patient satisfaction, a good NPS, and a low rate of operative reintervention.
Level IV evidence. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Wrist Surgery)
Source: Journal of Wrist Surgery - January 16, 2024 Category: Orthopaedics Authors: Mcintyre, Joshua L. Stirling, Paul H.C. Mceachan, Jane Tags: Scientific Article Source Type: research
Airway pepsinogen A4 identifies lung transplant recipients with microaspiration and predicts chronic lung allograft dysfunction
Aspiration is a known risk-factor for adverse outcomes post-lung transplantation. Airway bile acids are the gold-standard biomarker of aspiration – however they are released into the duodenum and likely reflect concurrent gastrointestinal dysmotility. Previous studies investigating total airway pepsin have found conflicting results on its relationship with adverse outcomes post-lung transplantation. These studies measured total pepsin and p epsinogen in the airways. Certain pepsinogens are constitutively expressed in the lungs while others, like pepsinogen A4 (PGA4), are not. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 9, 2024 Category: Transplant Surgery Authors: Rayoun Ramendra, Allen Duong, Chen Yang Kevin Zhang, Ella Huszti, Xuanzi Zhou, Jan Havlin, Rasheed Ghany, Marcelo Cypel, Jonathan C. Yeung, Shaf Keshavjee, Andrew T. Sage, Tereza Martinu Source Type: research
Peroral Endoscopic Myotomy For Spastic Esophageal Dysmotility Among Opioid Users: Multicenter Propensity Score Match Study
Opioid induced esophageal disorder (OIED) often presents as spastic esophageal disorders (SEDs) and esophagogastric junction outflow obstruction (EGJOO). We aimed to evaluate and compare clinical outcomes of POEM for SEDs and EGJOO among opioid users and non-users. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 3, 2024 Category: Gastroenterology Authors: BahaAldeen Bani Fawwaz, Yiyang Zhang, Aimen Farooq, Venkata S. Gorrepati, Justin F. Forde, Andrew Canakis, Raymond Kim, Michael Ma, Petros Benias, Simon Che, Michael B. Ujiki, Andrew A. Li, Joo Ha Hwang, Chiemeziem Eke, Prashant Kedia, Abraham Yu, Irteza Source Type: research
Cardiac Biomarkers In Amyloidosis Predict Small Intestinal Bacterial Overgrowth
This study evaluates associations between cardiac biomarkers (NT-proBNP level, echocardiographic indices) and extracardiac biomarkers in the gut, specifically non-invasive GI breath testing for SIBO. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Frederick Chua, Shoujit Banerjee, David C. Kunkel, Dawn Lombardo, Roxana Ghashghaei Tags: 371 Source Type: research
Impedance planimetry and panometry (EndoFLIP ™) can replace manometry in preoperative anti-reflux surgery assessment
ConclusionImpedance planimetry and panometry can assess motility under general anesthesia or sedation and is highly sensitive to peristaltic dysfunction. Panometry is a novel tool that has potential to streamline and improve patient care and therefore should be considered as an alternative to HRM, especially in patients in which HRM would be inaccessible or poorly tolerated. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - January 1, 2024 Category: Surgery Source Type: research
Evaluating the molecular and genetic mechanisms underlying gut motility disorders
Expert Rev Gastroenterol Hepatol. 2023 Dec 20. doi: 10.1080/17474124.2023.2296558. Online ahead of print.ABSTRACTINTRODUCTION: Gastrointestinal (GI) motility disorders comprise a wide range of different diseases affecting the structural or functional integrity of the GI neuromusculature. Their clinical presentation and burden of disease depends on the predominant location and extent of gut involvement as well as the component of the gut neuromusculature affected.AREAS COVERED: A comprehensive literature review was conducted using the PubMed and Medline databases to identify articles related to GI motility and functional di...
Source: Expert Review of Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Authors: Atchariya Chanpong Maria M Alves Elena Bonora Roberto De Giorgio Nikhil Thapar Source Type: research
Post-bariatric Surgery Changes in Secondary Esophageal Motility and Distensibility Parameters
ConclusionBariatric surgery affects esophageal and GEJ physiology, and it is associated with higher rates of secondary dysmotility. DH patients have even higher rates of dysmotility. Further studies assessing clinical data and their correlation with manometric and pH-metric findings are needed.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - December 20, 2023 Category: Surgery Source Type: research
GSE220038 A Seed Sequence Variant in miR-145-5p causes Multisystem Smooth Muscle Dysfunction Syndrome (MSMDS)
We describe a patient with multiple major manifestations of MSMDS including steno-occlusive cerebrovascular arteriopathy, prune belly syndrome, gastrointestinal dysmotility, bladder dysfunction, and pupillary hyporeactivity without variation in ACTA2. Whole genome sequencing revealed a single nucleotide variant contained within the seed sequence of MIR145, which encodes the smooth muscle associated microRNA; hsa-miR-145-5p. RNA expression analysis on patient-derived fibroblasts was consistent with actin cytoskeletal dysfunction, and mutant miR-145-5p was unable to mediate cytoskeletal modulation of smooth muscle cells. MSM...
Source: GEO: Gene Expression Omnibus - December 14, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Preventative strategies for low anterior resection syndrome
ConclusionsTo date, there is a limited evidence base for all preventative strategies including IONM, RAS, PFP and TAI. These strategies are limited by either access (IONM, RAS and PFP) or acceptability (PFP and TAI), which are both key to the success of any intervention. The results of ongoing trials will serve to assess acceptability, while technological advancement may improve access to some of the aforementioned strategies. (Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - December 13, 2023 Category: Surgery Source Type: research
Nutrition support in the pediatric total pancreatectomy with islet autotransplantation recipient
Nutr Clin Pract. 2023 Dec 10. doi: 10.1002/ncp.11101. Online ahead of print.ABSTRACTFor children with diminished quality of life and chronic pain caused by acute recurrent or chronic pancreatitis who are undergoing total pancreatectomy with islet autotransplantation, postoperative nutrition support has several unique characteristics. Surgical complications may lead to delays in nutrition support initiation or require modifications to the regimen. Early postoperative dysmotility requires the use of temporary enteral nutrition until this improves. The resultant complete exocrine pancreatic insufficiency necessitates lifelong...
Source: Nutrition in Clinical Practice - December 11, 2023 Category: Nutrition Authors: Elissa M Downs Amanda Brun Melena D Bellin Source Type: research
