TWiV 527: City mouse, country mouse
The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: […] (Source: virology blog)
Source: virology blog - December 30, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology deer mouse enteric nervous system flavivirus hantavirus hantavirus pulmonary syndrome IBS inflammatory bowel syndrome intestinal dysmotility syndrome neurotropic outbreak Peromyscus maniculatus sin nombre viru Source Type: blogs

Viral infections of the enteric nervous system and intestinal dysmotility
Intestinal dysmotility disorders such as irritable bowel syndrome affect 10-30% of humans in Western countries. Some of these diseases appear to correlate with viral infection. Inoculation of mice with neurotropic flaviviruses leads to injury and death of enteric neurons, inflammation, intestinal dilation and retarded bowel transit, providing a model for studying and treating these human […] (Source: virology blog)
Source: virology blog - December 28, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information bowel motility enteric nervous system enteric neurons flavivirus inflammatory bowel syndrome intestinal dysmotility disorder neurotropic viral viruses West Nile virus zika virus Source Type: blogs

E-Motion System for Stimulating Esophagus Helps Restart Digestive System, Cleared in EU
E-Motion Medical, an Israeli company, won the European CE Mark for its E-Motion System that stimulates the esophageal peristalsis in order restore failing motor activities of the digestive system. Patients suffering from acute gastrointestinal dysmotility (GID), which includes many, if not most, of the critically ill, require a great deal of care and multifaceted treatment. Complications are common, so novel treatment options that work well would be welcome by clinicians in the ICU and other wards. The E-Motion System sends patterns of electrical current through a feeding tube that has electrodes on its surface. As fo...
Source: Medgadget - November 20, 2018 Category: Medical Devices Authors: Editors Tags: Critical Care GI Source Type: blogs

IBS is no BS
Millions of people are diagnosed with irritable bowel syndrome (IBS) every year making it one of the most common gastrointestinal (GI) conditions. Despite its prevalence, there remain many misconceptions about IBS among both patients and doctors. Here we review some basic concepts in hopes of demystifying this nebulous syndrome. What is IBS? Irritable bowel syndrome is defined by a constellation of symptoms including abdominal pain and altered bowel habits (diarrhea or constipation) that persist for a prolonged period of time. There is no blood test, radiology study or endoscopic procedure that can definitively diagnose IB...
Source: Kevin, M.D. - Medical Weblog - February 14, 2015 Category: Journals (General) Authors: Tags: Conditions GI Source Type: blogs

Cases: Second-Line Anti-emetic Therapies for Refractory Chemotherapy-Induced Nausea and Vomiting (CINV)
Discussion:Nausea and vomiting (NV) are commonly reported side effects with chemotherapy.1 The primary pathway for NV involves the chemotherapy drugs directly stimulating the chemoreceptor trigger zone (CTZ), in the area postrema at the base of the fourth ventricle. Activated receptors in the CTZ transmit signals to the vomiting center in the brainstem to produce NV. Receptors in the CTZ include serotonergic receptor 5-hydroxytryptamine type 3 (5-HT3), dopaminergic (D2) and neurokinin type 1 (NK-1) receptors. In addition, chemotherapy can damage GI mucosa causing local release of 5-HT3 neurotransmitters by gut enterochrom...
Source: Pallimed: A Hospice and Palliative Medicine Blog - August 25, 2014 Category: Palliative Carer Workers Authors: Christian Sinclair Source Type: blogs

Irritable Bowel Syndrome (IBS) vs. GI Dysmotility: How Do You Differentiate?
Is it IBS or GI dysmotility? In order to receive the best care possible, this patient appeals to a gastrointestinal (GI) specialist to help differentiate between these two potentially debilitating conditions.Contributor: John PittsPublished: Apr 17, 2013 (Source: Most Recent Health Wellness - Associated Content)
Source: Most Recent Health Wellness - Associated Content - April 17, 2013 Category: Other Conditions Source Type: blogs

Fibro what?
So I was told last September that I have fibromyalgia by my rheumatologist. I had been referred to her by my pain management doctor who had been treating me for my back pain from degenerating disks. I also had pain in lots of other places that was getting worse over the years as opposed to better. His diagnosis to my rheumatologist was myofascial pain or fibromyalgia with possible rheumatoid arthritis.Well the rheumatologist confirmed within ten minutes of meeting me that I had fibromyalgia. My pain doctor had put me on Savella, Lyrica, and Cymbalta at different times in the past to treat my pain. Those are the only medica...
Source: Caroline's Breast Cancer Blog - February 22, 2013 Category: Cancer Tags: symptoms fibromyalgia medication pain treatment Source Type: blogs