Early-life exposure to perfluoroalkyl substances and serum antibody concentrations towards common childhood vaccines in 18-month-old children in the Odense Child cohort
Environ Res. 2023 Nov 30:117814. doi: 10.1016/j.envres.2023.117814. Online ahead of print.ABSTRACTExposure to per- and polyfluoroalkyl substances (PFAS) has been associated with reduced antibody response to childhood vaccinations. Previous studies have mostly focused on antibodies against diphtheria or tetanus, while fewer studies have assessed antibodies toward attenuated viruses, such as measles, mumps or rubella (MMR). Therefore, we set out to determine associations between prenatal and early postnatal PFAS exposure and vaccine-specific Immunoglobulin G (IgG) in the background-exposed Odense Child Cohort. Blood samples ...
Source: Environmental Research - December 2, 2023 Category: Environmental Health Authors: Annika Sigvaldsen Frederik Damsgaard H øjsager Helene Martina Paarup Iben Have Beck Amalie Timmermann Henriette Boye Flemming Nielsen Thorhallur I Halldorsson Christel Nielsen S ören Möller Torben Barington Philippe Grandjean Tina Kold Jensen Source Type: research
The Ablation of Sensory Neurons Expressing the Nav1.8 Sodium Channel Improves Glucose Homeostasis and Amplifies the GLP ‐1 Signaling in Obese Female Mice
ConclusionThis data demonstrates sex-dependent differences in the Nav1.8-mediated regulation of energy metabolism, and provides new insights that may help in the design of sex-specific neuromodulation therapies for metabolic disorders induced by diets rich in fats and simple sugars. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - December 1, 2023 Category: Food Science Authors: Marina Roman í‐Pérez,
Clara Bullich‐Vilarrubias,
Inmaculada López‐Almela,
Yolanda Sanz Tags: Research Article Source Type: research
Risk of New Retinal Vascular Occlusion After mRNA COVID-19 Vaccination Within Aggregated Electronic Health Record Data
To the Editor We read with great interest a recent study by Dorney et al, concluding that there was no association between messenger RNA (mRNA) COVID-19 vaccination and newly diagnosed retinal vascular occlusion (RVO) with similar rates compared with those following influenza and tetanus, diphtheria, and pertussis (Tdap) vaccines. However, we have several methodological concerns and suggestions. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - December 1, 2023 Category: Opthalmology Source Type: research
The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria
Infect Disord Drug Targets. 2023 Nov 28. doi: 10.2174/0118715265251299231117045940. Online ahead of print.ABSTRACTDiphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not treated. The reemergence of diphtheria in Nigeria is most likely due to a combination of factors, including gaps in routine immuniz...
Source: Infectious Disorders Drug Targets - November 29, 2023 Category: Infectious Diseases Authors: Pius Omoruyi Omosigho Okesanya Olalekan John Olaniyi Abideen Adigun Hakeem Kayode Hassan Olaleke Noah Olabode Abioye Sunday Micheal Usman Abubakar Haruna Amandeep Singh Emery Manirambona Source Type: research
Recurrent diphtheria outbreaks in Nigeria: A review of the underlying factors and remedies
ConclusionThe underlying causes of Nigeria's low DTP coverage and DAT supply are multifactorial. Both short-term and long-term measures are needed to control this outbreak and prevent future occurrences. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 29, 2023 Category: Allergy & Immunology Authors: Nasir Abdulrasheed,
Lukman Lawal,
Abdulazeez B. Mogaji,
Ahmed O. Abdulkareem,
Abdulrahman K. Shuaib,
Sodiq G. Adeoti,
Opeyemi P. Amosu,
Abdulmujeeb O. Muhammad ‐Olodo,
Abdulwahab O. Lawal,
Tawakalitu A. Jaji,
Toufik Abdul‐Rahman Tags: REVIEW ARTICLE Source Type: research
Missed opportunities: Reducing zero dose children amongthe urban poor after COVID, Mumbai India, 2022
Vaccine. 2023 Nov 27:S0264-410X(23)01339-7. doi: 10.1016/j.vaccine.2023.11.027. Online ahead of print.ABSTRACTReaching urban poor populations poses challenges for equitable immunization coverage. Furthermore, COVID disrupted routine immunization services. In Mumbai, India, first dose diphtheria tetanus pertussis containing vaccine (DTPCV1)coverage dropped from 88% (2019) to 76% (2021). We identified and characterized 125 zero-dose (those withoutDTPCV1)migrant children in urban Mumbai in October 2022. Almost half were born elsewhere than Mumbai; 53% resided at their present location for less than a year. More than half were...
Source: Vaccine - November 28, 2023 Category: Allergy & Immunology Authors: Meeta Dhaval Vashi Margaret Watkins Source Type: research
Vaccination coverage of children with rheumatic diseases compared with healthy controls: a retrospective case-control study
CONCLUSION: Vaccination coverage of PedRD patients has been shown to lag behind the routine vaccination schedule (71.4%). In addition to new recommendations, electronic health system records for vaccination may be appropriate for the follow-up of these patients, and the addition of reminder alerts may be useful to reduce the rate of missed vaccinations.PMID:37997766 | DOI:10.1080/00325481.2023.2287988 (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - November 24, 2023 Category: Internal Medicine Authors: Özlem Akgün Fatma G ül Demirkan G ülşah Kavrul Kayaalp Merve Erdemir Nergis Akay Figen Çakmak Mustafa Önel Gonca Keskindemirci Rukiye Eker Ömeroğlu Emine G ülbin Gökçay Nuray Aktay Ayaz Source Type: research
TroR is the primary regulator of the iron homeostasis transcription network in the halophilic archaeon Haloferax volcanii
Nucleic Acids Res. 2023 Nov 22:gkad997. doi: 10.1093/nar/gkad997. Online ahead of print.ABSTRACTMaintaining the intracellular iron concentration within the homeostatic range is vital to meet cellular metabolic needs and reduce oxidative stress. Previous research revealed that the haloarchaeon Halobacterium salinarum encodes four diphtheria toxin repressor (DtxR) family transcription factors (TFs) that together regulate the iron response through an interconnected transcriptional regulatory network (TRN). However, the conservation of the TRN and the metal specificity of DtxR TFs remained poorly understood. Here we identified...
Source: Cell Research - November 23, 2023 Category: Cytology Authors: Mar Martinez Pastor Saaz Sakrikar Sungmin Hwang Rylee K Hackley Andrew L Soborowski Julie A Maupin-Furlow Amy K Schmid Source Type: research
Acceptance of Routine Vaccines in Pregnancy during the COVID-19 Pandemic
Conclusion During the COVID-19 pandemic era, pregnant people at large were more likely to accept the influenza vaccine. However, this trend did not apply to Tdap, and high-risk groups with public insurance and medical comorbidities. This study highlights potential disparities in vaccination rates, which need to be accounted for when evaluating national vaccine trends. These data support increased efforts in vaccine counseling for high-risk populations.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | ...
Source: American Journal of Perinatology - November 21, 2023 Category: Perinatology & Neonatology Authors: Perelman, Allison D. Trostle, Megan E. Pecoriello, Jillian Quinn, Gwendolyn P. Roman, Ashley S. Penfield, Christina A. Tags: Original Article Source Type: research
Cancers, Vol. 15, Pages 5472: CX3CR1-Expressing Immune Cells Infiltrate the Tumor Microenvironment and Promote Radiation Resistance in a Mouse Model of Lung Cancer
Conclusions: CX3CR1-expressing mononuclear cells invade the TME after radiation therapy in a mouse lung cancer model. CX3CR1 cell depletion attenuates tumor progression following radiation and sensitizes the tumor to S–phase-specific chemotherapy. Thus, we propose a novel strategy to improve radiation sensitivity by targeting the CX3CR1-expressing immune cells. (Source: Cancers)
Source: Cancers - November 19, 2023 Category: Cancer & Oncology Authors: Tamar Ben-Mordechai Yaacov R. Lawrence Zvi Symon Ariel Shimoni-Sebag Uri Amit Tags: Article Source Type: research
Coverage with Selected Vaccines and Exemption from School Vaccine Requirements Among Children in Kindergarten - United States, 2022-23 School Year
MMWR Morb Mortal Wkly Rep. 2023 Nov 10;72(45):1217-1224. doi: 10.15585/mmwr.mm7245a2.ABSTRACTU.S. states and local jurisdictions set vaccination requirements for school attendance and conditions and procedures for exemptions from these requirements. States annually report data to CDC on the number of children in kindergarten who meet, are exempt from, or are in the process of meeting requirements. National- and state-level estimates for complete vaccination with measles, mumps, and rubella vaccine (MMR); diphtheria, tetanus, and acellular pertussis vaccine (DTaP); poliovirus vaccine (polio); and varicella vaccine (VAR); ex...
Source: MMWR Morb Mortal Wkl... - November 9, 2023 Category: Epidemiology Authors: Ranee Seither Oyindamola Bidemi Yusuf Devon Dramann Kayla Calhoun Agnes Mugerwa-Kasujja Cynthia L Knighton Source Type: research
Coverage with Selected Vaccines and Exemption from School Vaccine Requirements Among Children in Kindergarten - United States, 2022-23 School Year
MMWR Morb Mortal Wkly Rep. 2023 Nov 10;72(45):1217-1224. doi: 10.15585/mmwr.mm7245a2.ABSTRACTU.S. states and local jurisdictions set vaccination requirements for school attendance and conditions and procedures for exemptions from these requirements. States annually report data to CDC on the number of children in kindergarten who meet, are exempt from, or are in the process of meeting requirements. National- and state-level estimates for complete vaccination with measles, mumps, and rubella vaccine (MMR); diphtheria, tetanus, and acellular pertussis vaccine (DTaP); poliovirus vaccine (polio); and varicella vaccine (VAR); ex...
Source: MMWR Morb Mortal Wkl... - November 9, 2023 Category: Epidemiology Authors: Ranee Seither Oyindamola Bidemi Yusuf Devon Dramann Kayla Calhoun Agnes Mugerwa-Kasujja Cynthia L Knighton Source Type: research
