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Global vaccine coverage and childhood survival estimates: 1990-2019
CONCLUSION: Vaccines continue to reduce childhood mortality significantly, especially in Gavi-supported countries, emphasizing the need for increased investment in routine immunization programmes.PMID:38562199 | PMC:PMC10976869 | DOI:10.2471/BLT.23.290129 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 2, 2024 Category: International Medicine & Public Health Authors: Haijun Zhang Bryan Patenaude Haonan Zhang Mark Jit Hai Fang Source Type: research

Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research

Public Health Risks of PFAS-Related Immunotoxicity Are Real
AbstractPurpose of ReviewThe discovery of per- and polyfluoroalkyl substances (PFAS) in the environment and humans worldwide has ignited scientific research, government inquiry, and public concern over numerous adverse health effects associated with PFAS exposure. In this review, we discuss the use of PFAS immunotoxicity data in regulatory and clinical decision-making contexts and question whether recent efforts adequately account for PFAS immunotoxicity in public health decision-making.Recent FindingsGovernment and academic reviews confirm the strongest human evidence for PFAS immunotoxicity is reduced antibody production...
Source: Current Environmental Health Reports - March 25, 2024 Category: Environmental Health Source Type: research

Is vaccination against measles, mumps, and rubella associated with reduced rates of antibiotic treatments among children below the age of 2 years? Nationwide register-based study from Denmark, Finland, Norway, and Sweden
CONCLUSIONS: Across the Nordic countries, receipt of MMR vaccine after DTaP3 was associated with an 11% lower rate of antibiotic treatments. The negative control analysis suggests that the findings are affected by residual confounding. Findings suggest that potential non-specific effects of MMR vaccine are of limited clinical and public health importance for the milder infections treated out-of-hospital in the Nordic setting.PMID:38508926 | DOI:10.1016/j.vaccine.2024.03.026 (Source: Vaccine)
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Lise Gehrt H élène Englund Ida Laake Heta Nieminen S ören Möller Berit Feiring Mika Lahdenkari Lill Trogstad Christine Stabell Benn Signe S ørup Source Type: research

Re-emergence of Diphtheria after COVID-19 Pandemic in Pakistan: time to consider booster vaccination strategies.
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - March 19, 2024 Category: Infectious Diseases Authors: Muhammad Salman, Muhammad Suleman Rana, Muhammad Usman, Muhammad Tahir, Kashif Muqarrab, Muhammad Babar Alam, Massab Umair, Muhammad Anas, Nadeem Ullah, Ayesha Farooq, Zurva Ashraf Tags: Letter to the Editor Source Type: research

Bona fide dendritic cells are pivotal precursors for osteoclasts
Conclusion Taken together, we identify DCs as important OC precursors in bone homeostasis and inflammation, which might open new avenues for therapeutic interventions in OC-mediated diseases. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - March 12, 2024 Category: Rheumatology Authors: Puchner, A., Simader, E., Saferding, V., Hofmann, M., Kieler, M., Brunner, J., Pfeifle, R., Niederreiter, B., Krönke, G., Schabbauer, G., Georgel, P., Diehl, G., Steiner, G., Hayer, S., Redlich, K., Smolen, J. S., Aletaha, D., Blüml, S. Tags: ARD, Animal models Source Type: research

Epidemiology of Reportable Bacterial Infectious Diseases in Saudi Arabia
ConclusionsThe future perspective of this research is to enhance disease surveillance reporting by including different variables, such as the source of infection, travel history, hospitalization, and mortality rates. The aim is to improve the sensitivity and specificity of surveillance data and focus on the mortality associated with bacterial pathogens to identify the most significant threats and set a public health priority. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 10, 2024 Category: Infectious Diseases Source Type: research

Vaccination during pregnancy and modulation of IgG response to pertussis vaccines in infants: The impact of different vaccine formulations
Vaccine. 2024 Mar 8:S0264-410X(24)00300-1. doi: 10.1016/j.vaccine.2024.03.015. Online ahead of print.ABSTRACTThe IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducting a secondary analysis of a large randomized controlled trial, we compared IgG levels against pertussis vaccine antigens in children of Td- and Tdap5-vaccinated mothers, after stratifying by infant vaccine formulation. A...
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Nicholas Brousseau Marie-Elen Angers-Goulet Robin Bastien Lingyun Ye Manish Sadarangani Scott A Halperin Source Type: research

Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice
Vestibular hair cells (HCs) are mechanoreceptors that sense head motions by modulating the firing rate of vestibular ganglion neurons (VGNs), whose central processes project to vestibular nucleus neurons (VNNs) and cerebellar neurons. We explored vestibular function after HC destruction in adult Pou4f3+/DTR (DTR) mice, in which injections of high-dose (50 ng/g) diphtheria toxin (DT) destroyed most vestibular HCs within 2 weeks. At that time, DTR mice had lost the horizontal vestibulo-ocular reflex (aVORH), and their VNNs failed to upregulate nuclear cFos expression in response to a vestibular stimulus (centrifugation)....
Source: Frontiers in Neurology - March 8, 2024 Category: Neurology Source Type: research

Co-administration of the adjuvanted recombinant zoster vaccine with other adult vaccines: An overview
CONCLUSIONS: Co-administration of RZV with routine vaccines does not significantly alter the reactogenicity, immunogenicity or safety of RZV or the co-administered vaccine. Healthcare practitioners should consider routine co-administration of RZV with other adult vaccines to improve vaccination coverage.PMID:38423814 | DOI:10.1016/j.vaccine.2024.02.035 (Source: Vaccine)
Source: Vaccine - February 29, 2024 Category: Allergy & Immunology Authors: S Omar Ali Christophe Dessart Raunak Parikh Source Type: research