GSE252959 Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow I
Contributors : Marta Ferreira-Gomes ; Gabriela M Guerra ; Katrin Lehmann ; Frederik Heinrich ; Pawel Durek ; Mir-Farzin MashreghiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensBone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone marrow (BM). Traj...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE253857 Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow II
Contributors : Marta Ferreira-Gomes ; Gabriela M Guerra ; Katrin Lehmann ; Frederik Heinrich ; Pawel Durek ; Mir-Farzin MashreghiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensBone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone marrow (BM). Traj...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
Balto and Togo during the cold winter of Alaska (1925): the two canine heroes in the fight against diphtheria.
In recent years, diphtheria has re-emerged in areas with inadequate vaccination coverage, and Europe has not been spared with several cases among migrants. Diphtheria is a potentially fatal infection caused mainly by toxigenic strains of Corynebacterium diphtheriae. Due to the high mortality rate, especially among young children, the fight against diphtheria is considered one of the first conquests of immunization. In the history of medicine, there is a unique case of an unconventional response to a diphtheria outbreak in which sled dogs were used to overcome the supply difficulties of diphtheria antitoxin. The mass media ...
Source: Journal of Preventive Medicine and Hygiene - April 15, 2024 Category: International Medicine & Public Health Authors: Omar Simonetti, Lavinia Cosimi, Marco Cigana, Mariano Martini, Stefano Di Bella, Arturo Penco Source Type: research
Neutralizing anti-diphtheria toxin scFv produced by phage display
CONCLUSION: This study describes the prosperous construction and isolation of scFv from the immune library, which specifically neutralizes diphtheria toxin. The HuscFv produced in this study can be a potential candidate to substitute the animal antibody for treating diphtheria and detecting toxins.PMID:38607601 | DOI:10.1007/s10529-024-03476-1 (Source: Biotechnology Letters)
Source: Biotechnology Letters - April 12, 2024 Category: Biotechnology Authors: Ehsan Khalili Mostafa Lakzaei Mahdi Aminian Source Type: research
Neutralizing anti-diphtheria toxin scFv produced by phage display
CONCLUSION: This study describes the prosperous construction and isolation of scFv from the immune library, which specifically neutralizes diphtheria toxin. The HuscFv produced in this study can be a potential candidate to substitute the animal antibody for treating diphtheria and detecting toxins.PMID:38607601 | DOI:10.1007/s10529-024-03476-1 (Source: Biotechnology Letters)
Source: Biotechnology Letters - April 12, 2024 Category: Biotechnology Authors: Ehsan Khalili Mostafa Lakzaei Mahdi Aminian Source Type: research
Neutralizing anti-diphtheria toxin scFv produced by phage display
CONCLUSION: This study describes the prosperous construction and isolation of scFv from the immune library, which specifically neutralizes diphtheria toxin. The HuscFv produced in this study can be a potential candidate to substitute the animal antibody for treating diphtheria and detecting toxins.PMID:38607601 | DOI:10.1007/s10529-024-03476-1 (Source: Biotechnology Letters)
Source: Biotechnology Letters - April 12, 2024 Category: Biotechnology Authors: Ehsan Khalili Mostafa Lakzaei Mahdi Aminian Source Type: research
Neutralizing anti-diphtheria toxin scFv produced by phage display
CONCLUSION: This study describes the prosperous construction and isolation of scFv from the immune library, which specifically neutralizes diphtheria toxin. The HuscFv produced in this study can be a potential candidate to substitute the animal antibody for treating diphtheria and detecting toxins.PMID:38607601 | DOI:10.1007/s10529-024-03476-1 (Source: Biotechnology Letters)
Source: Biotechnology Letters - April 12, 2024 Category: Biotechnology Authors: Ehsan Khalili Mostafa Lakzaei Mahdi Aminian Source Type: research
Neutralizing anti-diphtheria toxin scFv produced by phage display
CONCLUSION: This study describes the prosperous construction and isolation of scFv from the immune library, which specifically neutralizes diphtheria toxin. The HuscFv produced in this study can be a potential candidate to substitute the animal antibody for treating diphtheria and detecting toxins.PMID:38607601 | DOI:10.1007/s10529-024-03476-1 (Source: Biotechnology Letters)
Source: Biotechnology Letters - April 12, 2024 Category: Biotechnology Authors: Ehsan Khalili Mostafa Lakzaei Mahdi Aminian Source Type: research
Type selective ablation of postnatal slow and fast fatigue-resistant motor neurons in mice induces late onset kinetic and postural tremor following fiber-type transition and myopathy
Exp Neurol. 2024 Apr 8:114772. doi: 10.1016/j.expneurol.2024.114772. Online ahead of print.ABSTRACTAnimals on Earth need to hold postures and execute a series of movements under gravity and atmospheric pressure. VAChT-Cre is a transgenic Cre driver mouse line that expresses Cre recombinase selectively in motor neurons of S-type (slow-twitch fatigue-resistant) and FR-type (fast-twitch fatigue-resistant). Sequential motor unit recruitment is a fundamental principle for fine and smooth locomotion; smaller-diameter motor neurons (S-type, FR-type) first contract low-intensity oxidative type I and type IIa muscle fibers, and the...
Source: Experimental Neurology - April 10, 2024 Category: Neurology Authors: Hidemi Misawa Kai Kamishima Tenkei Koyama Lisa Ohgaki Yuta Morisaki Tomoyuki Yamanaka Shigeyoshi Itohara Shoko Sawano Wataru Mizunoya Naomichi Ogihara Source Type: research
Type selective ablation of postnatal slow and fast fatigue-resistant motor neurons in mice induces late onset kinetic and postural tremor following fiber-type transition and myopathy
Exp Neurol. 2024 Apr 8:114772. doi: 10.1016/j.expneurol.2024.114772. Online ahead of print.ABSTRACTAnimals on Earth need to hold postures and execute a series of movements under gravity and atmospheric pressure. VAChT-Cre is a transgenic Cre driver mouse line that expresses Cre recombinase selectively in motor neurons of S-type (slow-twitch fatigue-resistant) and FR-type (fast-twitch fatigue-resistant). Sequential motor unit recruitment is a fundamental principle for fine and smooth locomotion; smaller-diameter motor neurons (S-type, FR-type) first contract low-intensity oxidative type I and type IIa muscle fibers, and the...
Source: Experimental Neurology - April 10, 2024 Category: Neurology Authors: Hidemi Misawa Kai Kamishima Tenkei Koyama Lisa Ohgaki Yuta Morisaki Tomoyuki Yamanaka Shigeyoshi Itohara Shoko Sawano Wataru Mizunoya Naomichi Ogihara Source Type: research
Childhood vaccination coverage and regional differences in Swiss birth cohorts 2012-2021: Are we on track?
CONCLUSION: Full vaccination coverage in Swiss children is still below 90 % with many vaccinations administered delayed. Given regional differences, missed or delayed booster vaccinations, and differences in vaccine-specific acceptability, more effort may be needed to achieve national vaccination targets.PMID:38593195 | DOI:10.1016/j.vaccine.2023.10.043 (Source: Vaccine)
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Simeon J Z ürcher Andri Signorell Anja L échot-Huser Christoph Aebi Carola A Huber Source Type: research
Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia: A multicenter retrospective study
CONCLUSION: In Saudi Arabia, patients with DM showed higher vaccination rates for annual influenza and COVID-19 vaccines compared to other vaccinations such as herpes zoster, Tdap, pneumococcal, and HPV. Factors such as vaccine recommendations provided by family physicians or specialists, the site of care, income level, DM-related hospitalization history, residency site, HbA1c level, and health sector type can significantly influence the vaccination rate in patients with DM.PMID:38591075 | PMC:PMC10999047 | DOI:10.4239/wjd.v15.i3.440 (Source: Herpes)
Source: Herpes - April 9, 2024 Category: Infectious Diseases Authors: Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel Heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Source Type: research
Childhood vaccination coverage and regional differences in Swiss birth cohorts 2012-2021: Are we on track?
CONCLUSION: Full vaccination coverage in Swiss children is still below 90 % with many vaccinations administered delayed. Given regional differences, missed or delayed booster vaccinations, and differences in vaccine-specific acceptability, more effort may be needed to achieve national vaccination targets.PMID:38593195 | DOI:10.1016/j.vaccine.2023.10.043 (Source: Vaccine)
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Simeon J Z ürcher Andri Signorell Anja L échot-Huser Christoph Aebi Carola A Huber Source Type: research
Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis in Non-small Cell Lung Cancer Cell Line
CONCLUSION: Taken together, DTA-triCRGDK is a promising tool for targeted therapy of NRP-1 overexpressing cancer cells.PMID:38584554 | DOI:10.2174/0113816128292382240325074032 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Sara Eghtedari Mahdi Behdani Fatemeh Kazemi-Lomedasht Source Type: research
Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis in Non-small Cell Lung Cancer Cell Line
CONCLUSION: Taken together, DTA-triCRGDK is a promising tool for targeted therapy of NRP-1 overexpressing cancer cells.PMID:38584554 | DOI:10.2174/0113816128292382240325074032 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Sara Eghtedari Mahdi Behdani Fatemeh Kazemi-Lomedasht Source Type: research
