Toxigenic cutaneous diphtheria without recent travel, Sydney, Australia, 2022
Med J Aust. 2023 Dec 18. doi: 10.5694/mja2.52190. Online ahead of print.NO ABSTRACTPMID:38111182 | DOI:10.5694/mja2.52190 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - December 19, 2023 Category: General Medicine Authors: Caitlin Swift Anthea L Katelaris Thea Briggen Tiqui Julie Smith Tracey Papa Estella Janz-Robinson Trang Nguyen Qinning Wang Jenny Draper Vitali Sintchenko Debbie Je Marriott Vicky Sheppeard Source Type: research
Toxigenic cutaneous diphtheria without recent travel, Sydney, Australia, 2022
Med J Aust. 2023 Dec 18. doi: 10.5694/mja2.52190. Online ahead of print.NO ABSTRACTPMID:38111182 | DOI:10.5694/mja2.52190 (Source: Med J Aust)
Source: Med J Aust - December 19, 2023 Category: General Medicine Authors: Caitlin Swift Anthea L Katelaris Thea Briggen Tiqui Julie Smith Tracey Papa Estella Janz-Robinson Trang Nguyen Qinning Wang Jenny Draper Vitali Sintchenko Debbie Je Marriott Vicky Sheppeard Source Type: research
Toxigenic cutaneous diphtheria without recent travel, Sydney, Australia, 2022
Med J Aust. 2023 Dec 18. doi: 10.5694/mja2.52190. Online ahead of print.NO ABSTRACTPMID:38111182 | DOI:10.5694/mja2.52190 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - December 19, 2023 Category: General Medicine Authors: Caitlin Swift Anthea L Katelaris Thea Briggen Tiqui Julie Smith Tracey Papa Estella Janz-Robinson Trang Nguyen Qinning Wang Jenny Draper Vitali Sintchenko Debbie Je Marriott Vicky Sheppeard Source Type: research
Coverage, Trends, and Inequalities of Maternal, Newborn, and Child Health Indicators among the Poor and Non-Poor in the Most Populous Cities from 38 Sub-Saharan African Countries
AbstractRapid urbanization is likely to be associated with suboptimal access to essential health services. This is especially true in cities from sub-Saharan Africa (SSA), where urbanization is outpacing improvements in infrastructure. We assessed the current situation in regard to several markers of maternal, newborn, and child health, including indicators of coverage of health interventions (demand for family planning satisfied with modern methods, at least four antenatal care visits (ANC4+), institutional birth, and three doses of DPT vaccine[diphtheria, pertussis and tetanus]) and health status (stunting in children un...
Source: Journal of Urban Health - December 18, 2023 Category: Health Management Source Type: research
Trends of measles in Tanzania: a five-year review of case-based surveillance data, 2018-2022
Vaccines provide a safe and cost-effective solution to vaccine-preventable infectious diseases. However, vaccine-preventable infectious diseases still pose a serious public health threat especially in the world's poor regions[1]. In sub-Saharan Africa, this burden is further aggravated by the occurrence of concurrent epidemics such as Coronavirus Disease 2019 (COVID-19), Ebola virus disease, monkeypox, and measles overstretching the already weak public health system[2]. In addition to human conflicts, natural disasters, vaccine hesitancy, and the COVID-19 pandemic has disrupted routine immunisation services leaving million...
Source: International Journal of Infectious Diseases - December 17, 2023 Category: Infectious Diseases Authors: Fausta Michael, Mariam M. Mirambo, Gerald Misinzo, Omary Minzi, Medard Beyanga, Delphinus Mujuni, Florence S Kalabamu, Elias N Nyanda, Mary Mwanyika-Sando, Daniel Ndiyo, Richard Kasonogo, Abbas Ismail, Andrew Bahati, Farida Hassan, Elangiringa Kaale, John Source Type: research
Trends of measles in Tanzania: A 5-year review of case-based surveillance data, 2018-2022
Vaccines provide a safe and cost-effective solution to vaccine-preventable infectious diseases. However, vaccine-preventable infectious diseases still pose a serious public health threat, especially in the world's poor regions [1]. In sub-Saharan Africa, this burden is further aggravated by the occurrence of concurrent epidemics such as COVID-19, Ebola virus disease, monkeypox, and measles overstretching the already weak public health system [2]. In addition to human conflicts, natural disasters, and vaccine hesitancy, the COVID-19 pandemic has disrupted routine immunization services leaving millions of children under-vacc...
Source: International Journal of Infectious Diseases - December 17, 2023 Category: Infectious Diseases Authors: Fausta Michael, Mariam M. Mirambo, Gerald Misinzo, Omary Minzi, Medard Beyanga, Delphinus Mujuni, Florence S. Kalabamu, Elias N. Nyanda, Mary Mwanyika-Sando, Daniel Ndiyo, Richard Kasonogo, Abbas Ismail, Andrew Bahati, Farida Hassan, Eliangiringa Kaale, J Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Trends in Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Trends in Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
Diphthamide - a conserved modification of eEF2 with clinical relevance
Trends Mol Med. 2023 Dec 13:S1471-4914(23)00270-8. doi: 10.1016/j.molmed.2023.11.008. Online ahead of print.ABSTRACTDiphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndr...
Source: Trends in Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Raffael Schaffrath Ulrich Brinkmann Source Type: research
Expression mapping of GREM1 and functional contribution of its-secreting-cells in the brain using transgenic mouse models
Exp Neurol. 2023 Dec 8:114649. doi: 10.1016/j.expneurol.2023.114649. Online ahead of print.ABSTRACTGremlin 1 (Grem1) is a secreted protein that antagonizes bone morphogenetic proteins (BMPs). While abnormal Grem1 expression has been reported to cause behavioral defects in postpartum mice, the spatial and cellular distribution of GREM1 in the brain and the influence of the Grem1-secreating cells on brain function and behavior remain unclear. To address this, we designed a genetic cassette incorporating a 3 × Flag-TeV-HA-T2A-tdTomato sequence, resulting in the creation of a novel Grem1Tag mouse model, expressing an epitope ...
Source: Experimental Neurology - December 10, 2023 Category: Neurology Authors: Peijia Yao Xueli Liu Qiang Miao Changxue Li Huaixiang Zhou Huiliang Li Xinliang Mao Xiaoyi Fang Ningning Li Source Type: research
Effective and safe transfer of maternal antibodies persisting two months postpartum following maternal immunization with different doses of recombinant pertussis-containing vaccines
CONCLUSIONS: BioNet licensed (TdaP5gen and Tdap2gen) and candidate vaccines (Tdap1gen and ap1gen) when given to pregnant women in the second or third trimester of gestation are safe and have induced passive pertussis immunity to infants.PMID:38061956 | DOI:10.1016/j.vaccine.2023.11.042 (Source: Vaccine)
Source: Vaccine - December 7, 2023 Category: Allergy & Immunology Authors: Kulkanya Chokephaibulkit Thanyawee Puthanakit Surasith Chaithongwongwatthana Niranjan Bhat Yuxiao Tang Suvaporn Anugulruengkitt Chenchit Chayachinda Sanitra Anuwutnavin Keswadee Lapphra Supattra Rungmaitree Monta Tawan Indah Andi-Lolo Renee Holt Librada F Source Type: research
Effective and safe transfer of maternal antibodies persisting two months postpartum following maternal immunization with different doses of recombinant pertussis-containing vaccines
CONCLUSIONS: BioNet licensed (TdaP5gen and Tdap2gen) and candidate vaccines (Tdap1gen and ap1gen) when given to pregnant women in the second or third trimester of gestation are safe and have induced passive pertussis immunity to infants.PMID:38061956 | DOI:10.1016/j.vaccine.2023.11.042 (Source: Vaccine)
Source: Vaccine - December 7, 2023 Category: Allergy & Immunology Authors: Kulkanya Chokephaibulkit Thanyawee Puthanakit Surasith Chaithongwongwatthana Niranjan Bhat Yuxiao Tang Suvaporn Anugulruengkitt Chenchit Chayachinda Sanitra Anuwutnavin Keswadee Lapphra Supattra Rungmaitree Monta Tawan Indah Andi-Lolo Renee Holt Librada F Source Type: research
Early-life exposure to perfluoroalkyl substances and serum antibody concentrations towards common childhood vaccines in 18-month-old children in the Odense Child cohort
Environ Res. 2023 Nov 30:117814. doi: 10.1016/j.envres.2023.117814. Online ahead of print.ABSTRACTExposure to per- and polyfluoroalkyl substances (PFAS) has been associated with reduced antibody response to childhood vaccinations. Previous studies have mostly focused on antibodies against diphtheria or tetanus, while fewer studies have assessed antibodies toward attenuated viruses, such as measles, mumps or rubella (MMR). Therefore, we set out to determine associations between prenatal and early postnatal PFAS exposure and vaccine-specific Immunoglobulin G (IgG) in the background-exposed Odense Child Cohort. Blood samples ...
Source: Environmental Research - December 2, 2023 Category: Environmental Health Authors: Annika Sigvaldsen Frederik Damsgaard H øjsager Helene Martina Paarup Iben Have Beck Amalie Timmermann Henriette Boye Flemming Nielsen Thorhallur I Halldorsson Christel Nielsen S ören Möller Torben Barington Philippe Grandjean Tina Kold Jensen Source Type: research
