What's the deal with "Auvelity"? (new NMDA receptor antagonist)
Got a notification that some biotech stock shot up about 35% today. Turns out that company just got FDA approval for "auvelity" and is marketing it as the greatest thing to come out for depression treatment since SSRIs. Looking into it the chemical formulation seems to be "dextromethorphan HBr -bupropion HCl", and it has been challenging finding peer reviewed articles about how well it really works.
Perhaps I'm just too dumb to understand the pharmacology behind it, but isn't this...
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Source: Student Doctor Network - August 23, 2022 Category: Universities & Medical Training Authors: Monocles Tags: Psychiatry Source Type: forums
Re: Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis
(Source: BMJ Comments)
Source: BMJ Comments - August 21, 2022 Category: General Medicine Source Type: forums
'How Complex Systems Fail' and mental healthcare system design
I recently ran across this short summary of considerations for 'complex systems' in healthcare and was struck by how relevant some of the points were in relation to attempts to design complex systems to, say, 'prevent suicide,' especially considering the role of health care provider. I think it's worthy of discussion and am interested in others' opinions on it, especially if you've been in the role of trying to apply increasingly complex protocols, procedures, and rules relating to suicide...
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Source: Student Doctor Network - August 20, 2022 Category: Universities & Medical Training Authors: Fan_of_Meehl Tags: Psychology [Psy.D. / Ph.D.] Source Type: forums
Depression seems to be more a chemical imbalance among neurotransmitters.
(Source: BMJ Comments)
Source: BMJ Comments - August 19, 2022 Category: General Medicine Source Type: forums
Re: Antidepressants and the serotonin hypothesis of depression: What do antidepressants do?
(Source: BMJ Comments)
Source: BMJ Comments - August 17, 2022 Category: General Medicine Source Type: forums
Re: Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis
(Source: BMJ Comments)
Source: BMJ Comments - August 17, 2022 Category: General Medicine Source Type: forums
Re: “No convincing evidence” that depression is caused by low serotonin levels, say study authors
(Source: BMJ Comments)
Source: BMJ Comments - August 16, 2022 Category: General Medicine Source Type: forums
Old Threads That Did Not Age Well...Post Your Favorites...
Opioid Tapering or Discontinuation vs No Change for Opioid Overdose or Suicide
This comparative effectiveness study examines the association of opioid tapering or abrupt discontinuation with opioid overdose and suicide events among patients receiving a stable long-term opioid dosage without evidence of opioid misuse.
jamanetwork.com (Source: Student Doctor Network)
Source: Student Doctor Network - August 15, 2022 Category: Universities & Medical Training Authors: drusso Tags: Pain Medicine Source Type: forums
WAMC/List Rec ’s 521, 3.2 cGPA Non-trad
3.2 cGPA, 2.8 sGPA (includes DIY post bac)
521 MCAT
OH
White, non trad
Large state
3,500+ hours working as a PCA at a psych hospital
No research
Shadowed 2 psychiatrists and surgeon
500 hours of volunteering at national suicide hotline
10.
Master’s in Bioethics from Harvard Medical School, 3.9 GPA. This was after DIY post bac.
Lead a team that was a finalist in Silicon Valley Innovation Academy while a visiting student at Stanford University...
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Source: Student Doctor Network - August 1, 2022 Category: Universities & Medical Training Authors: fences84 Tags: What Are My Chances? WAMC Medical Source Type: forums
Thinking about leaving medical school for good. Need some advice (serious)
I'm about 1.5 months into medical school now and to be honest I'm not sure what I expected coming here, but I am really not enjoying it (I know this is normal for first year). I've been doing good so far and have honored all of my tests, but I still am not enjoying it. For the first time in my life I find myself suffering from pretty severe depression and anxiety (I'm already getting help) and I just can't imagine continuing to do this for the next 7+ years of my life. Prior to coming to...
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Source: Student Doctor Network - August 1, 2022 Category: Universities & Medical Training Authors: jsat Tags: Medical Students (MD) Source Type: forums
Thinking of a Career in Medicine and Pathology, Please Look at This.
Profession with overall highest suicide rate: Medicine
No. 1 cause of death of medical students: Suicide.
Career with the highest rate of female mental illness: Medicine
Profession with the highest rate of female infertility: Medicine (25% vs. 9% in general population)
Estimated percentage of physicians in their career with significant financial problems: 25%
And yet most leading academic scholars feel: U.S. physicians are entitled, too powerful, paid too much and...
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Source: Student Doctor Network - July 30, 2022 Category: Universities & Medical Training Authors: LADoc00 Tags: Pathology Source Type: forums
Blurry vision with SSRIs
Hi all,
I have a female patient in her late 50s who (very reluctantly) started taking lexapro for depression and has has significant benefit from it. She's been on it for a few months now but just told me that her vision became notably more blurry since she started this med. She had some age related changes in vision prior to starting lexapro and had used reading glasses before but said this was a pretty precipitous change.
I'm going to ask her to get an eye exam and am not concerned...
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Source: Student Doctor Network - July 29, 2022 Category: Universities & Medical Training Authors: FolieADeux Tags: Psychiatry Source Type: forums
Getting back into anesthesiology residency
I completed two years of an anesthesiology program after finishing IM residency. Skipped TY year went straight to CA1 and finished CA2 year. I had some horrible personal things happen to me after my CA1 year. Depression set in. Continued on for a year, but with the strain of residency and my unresolved depression, I couldn't do it anymore. I resigned in good standing with my program. Even got 94th percentile on ITE my CA2 year, but just couldn't keep going. I'm doing great now. Back...
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Source: Student Doctor Network - July 29, 2022 Category: Universities & Medical Training Authors: tom10 Tags: Anesthesiology Source Type: forums
Re: “No convincing evidence” that depression is caused by low serotonin levels, say study authors
(Source: BMJ Comments)
Source: BMJ Comments - July 26, 2022 Category: General Medicine Source Type: forums
The serotonin theory of depression: a systematic umbrella review of the evidence.. Thoughts?
Hi, anyone seen this recent Molecular Psychiatry paper also published in Nature?
The serotonin theory of depression: a systematic umbrella review of the evidence - Molecular Psychiatry
The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. PubMed, EMBASE and PsycINFO...
www.nature.com
...
Source: Student Doctor Network - July 24, 2022 Category: Universities & Medical Training Authors: ccool Tags: Psychiatry Source Type: forums
