Fur functions as an activator of T6SS-mediated bacterial dominance and virulence in Aeromonas hydrophila
In this study, the depression of A. hydrophila T6SS under iron-limiting conditions was detected. The ferric uptake regulator (Fur) was then found to act as an activator of T6SS by directly binding to the Fur box region in vipA promoter in the T6SS gene cluster. The transcription of vipA was repressed in Δfur. Moreover, the inactivation of Fur resulted in considerable defects in the interbacterial competition activity and pathogenicity of A. hydrophila in vitro and in vivo. These findings provide the first direct evidence that Fur positively regulates the expression and functional activity of T6SS in Gram-negative bacteria...
Source: Frontiers in Microbiology - February 8, 2023 Category: Microbiology Source Type: research
Excessive Crying, Irritability in Infancy Associated With Later Behavioral Problems
Infants who cry excessively (more than 3 hours at least 1 day/week) may be more likely to experience behavioral problems in childhood and adolescence than infants who cry less, suggests areport published yesterday in theJournal of the Academy of Child& Adolescent Psychiatry. Brain scans of these children at age 10 also revealed that the amygdala —a part of the brain involved with assessing threat and regulating emotional responses—was smaller in those who cried excessively and/or were irritable as infants.“Most infants who cry excessively grow to be healthy, typically developing children, and it remains reasonabl...
Source: Psychiatr News - February 7, 2023 Category: Psychiatry Tags: aggression crying depression externalizing infant internalizing irritability irritable Journal of the Academy of Child & Adolescent Psychiatry Source Type: research
Anxiety, Depression and Burnout Levels of Nurses Working in COVID-19 Intensive Care Units
Omega (Westport). 2023 Feb 6:302228231156313. doi: 10.1177/00302228231156313. Online ahead of print.ABSTRACTThis descriptive and correlation-seeking study was planned to determine the depression, anxiety, and burnout levels experienced by nurses working in COVID intensive care units. The survey consisted of three instruments: Nurse Identification Form, Hospital Anxiety and Depression Scale (HADS), and Burnout Measure Short Form (BMS). It was determined that the mean anxiety score of the nurses was 11.31 ± 4.41, the mean depression score was 10.03 ± 3.54, and the mean of burnout was 3.92 ± 1.75. In addition, it was deter...
Source: Omega - February 7, 2023 Category: Palliative Care Authors: Songul Karada ğ Bahar Çiçek Source Type: research
Study on the Mechanism of Hydrolyzed Seawater Pearl Tablet in Treating Chronic Sleep Deprivation Mice Model
CONCLUSION: Hydrolyzed seawater pearl tablet can improve the depression-like mental state of mice caused by chronic sleep deprivation. The mechanism involves improving the antioxidant activity of the hippocampus to eliminate the excessive ROS, which inhibits cell apoptosis and alleviates tissue structure damage. Meanwhile, it may also be involved in adjusting the microbiota level and improving the mental and behavioral activities of chronic sleep deprivation mice through the intestine-brain axis.PMID:36748223 | DOI:10.2174/1871530323666230206160722 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 7, 2023 Category: Drugs & Pharmacology Authors: Fei Luo Siyin Han Meng Xia Zhenxing Chen Peng Liu Jiang Lin Source Type: research
IJERPH, Vol. 20, Pages 2914: Nursing Interventions Against Bullying: A Systematic Review
Conclusions: It is clear that at the international level, nursing is involved in planning and developing autonomous and interdisciplinary interventions to address and prevent bullying. The evidence paves the way for school nurses and family and community nurses to take steps to tackle this phenomenon. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - February 7, 2023 Category: Environmental Health Authors: Mar ía del Carmen Celdrán-Navarro C ésar Leal-Costa Mar ía Suárez-Cortés Alonso Molina-Rodr íguez Ismael Jim énez-Ruiz Tags: Systematic Review Source Type: research
IJERPH, Vol. 20, Pages 2907: Prevalence and Factors Associated with Anxiety and Depression in Peruvian Medical Students
This study determined depression and anxiety prevalence and their associated factors in students from four medical schools in northern Peru. A cross-sectional study was conducted among medical students from Lambayeque, Peru. The Goldberg Anxiety and Zung Depression tests were applied. The dependent variables were depression and anxiety, and their association with covariates (age, sex, type of university, socioeconomic level, experience, family problem, and physical activity) was evaluated. Prevalence ratios were calculated using generalized linear models. Of 482 students, the prevalence of anxiety was 61.8% and depression ...
Source: International Journal of Environmental Research and Public Health - February 7, 2023 Category: Environmental Health Authors: Jorge L. Piscoya-Tenorio Walter V. Heredia-Rioja Noelia Morocho-Alburqueque Sandra Ze ña-Ñañez Palmer J. Hern ández-Yépez Cristian D íaz-Vélez Virgilo E. Failoc-Rojas Mario J. Valladares-Garrido Tags: Article Source Type: research
Postmortem injury evaluation using the Forensic Injury Severity Score Template (FISST): a preliminary study
This study aimed to present a system that can objectively and quantitatively determine the severity of postmortem injuries and that can be applied to forensic medicine. Subsequently, we applied this system to individual postmortem cases and analyzed the injuries identified during autopsy. We performed a retrospective study of 119 autopsies performed between 2018 and 2021. Data were categorized and analyzed using the Forensic Injury Severity Score Template (FISST), a scoring system developed based on the AIS and ISS. The mean FISST scores were as follows: men, 53.6; women, 46.8; 20 –65 years old, 55.6; older than 65 yea...
Source: Forensic Science, Medicine, and Pathology - February 7, 2023 Category: Forensic Medicine Source Type: research
Depressive symptoms and physical activity among community-dwelling perimenopausal women: a prospective longitudinal study
Women in perimenopause are vulnerable to depressive symptoms, and physical activity was reported to be a potential protective factor. The trajectories of physical activity and depressive symptoms over time and... (Source: BMC Psychiatry)
Source: BMC Psychiatry - February 7, 2023 Category: Psychiatry Authors: Chuanya Huang, Biru Luo, Jing Wang, Yiling Ao, Weijun Xiong and Shujuan Liao Tags: Research Source Type: research
The Buffering Role of Self-compassion in the Association Between Loneliness with Depressive Symptoms: A Cross-Sectional Survey Study Among Older Adults Living in Residential Care Homes During COVID-19
This study aimed to investigate whether loneliness mediates the effects of fear generated by a pandemic on depression. Additionally, we hypothesized that self-compassion moderates the effect of loneliness on depression. A sample comprised 323 older adults (females:n = 141, males:n = 182) withmean age = 74.98 years (standard deviation = 6.59, age 65–90) completed a survey comprising the Fear of COVID-19 Scale, De Jung Gierveld Loneliness Scale, the nine-item Patient Health Questionnaire, and the Self-compassion Scale. The results revealed that the total effect of fear on depression wa s statistically sig...
Source: International Journal of Mental Health and Addiction - February 7, 2023 Category: Addiction Source Type: research
The Relationships Between Suicidal Ideation, Meaning in Life, and Affect: a Network Analysis
This study aimed to explore dimension-level relationships between suicidal ideation, meaning in life, and affect in a joint framework using network analysis and to identify potential prevention and intervention targets to address suicidal ideation. A total of 852 healthy adults aged 18 –35 years completed self-report scales to assess suicidal ideation, meaning in life, and affect. A regularized partial correlation network was then built to examine the links between these dimensions. Expected influence and bridge expected influence values were calculated for each node. The preva lence of suicidal ideation was 4.2%. The s...
Source: International Journal of Mental Health and Addiction - February 7, 2023 Category: Addiction Source Type: research
Identifying depressive symptoms in patients with type 2 diabetes mellitus: the role of glucose variability and concomitant hypothyroidism
ConclusionIncreased GV, particularly a joint increase in FBS and HbA1c variability as represented by the composite index, can indicate a significant increase in DS that can be detected even in small-scale clinical settings. Concomitant hypothyroidism, although managed according to the guidelines, can still be a risk factor for depression in diabetes. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - February 7, 2023 Category: Endocrinology Source Type: research
Prevalence of comorbid depression and insomnia among veterans hospitalized for heart failure with alzheimer disease and related disorders
Heart failure (HF) is a highly prevalent medical condition in the United States.1 Older adults are more likely to experience significant functional challenges and disability following HF.2 Unfortunately, Alzheimer's disease or related dementia (ADRD) diagnoses are highly prevalent among patients with HF, complicating medical management,3 increasing healthcare costs,4,5 and often indicating a worse prognosis for both diseases.6,7 Thus, characterizing factors associated with increased risk of ADRD among HF patients, especially factors that could be addressed in the hospital setting, is an important step towards improving cli...
Source: The American Journal of Geriatric Psychiatry - February 7, 2023 Category: Geriatrics Authors: Zachary J. Kunicki, Rachel Frietchen, John E. McGeary, Lan Jiang, Matthew S. Duprey, Thomas Bayer, Mriganka Singh, Jennifer M. Primack, Catherine M. Kelso, Wen-Chih Wu, James L. Rudolph, Melanie L. Bozzay Tags: Regular Research Article Source Type: research
Suicide attempts in adolescents with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor therapy
Mental health is an integral part of cystic fibrosis (CF) care. In people with CF (pwCF), depression and anxiety are two to three times more prevalent compared to individuals in the general population (GP).  While the impact of the Covid-19 pandemic on mental health has led to higher rates of depression and anxiety in the United States, its impact on mental health within the sub-population of pwCF is not as clear. [2,3] However, during the pandemic, CF care and more specifically mental health care delivery to pwCF was significantly impaired. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 7, 2023 Category: Respiratory Medicine Authors: Meliksah Arslan, Sarah Chalmers, Kelly Rentfrow, Janelle M. Olson, Vicki Dean, Mark E. Wylam, Nadir Demirel Tags: Case Report Source Type: research
Mechanisms of action and processes of yoga-based group intervention for inpatients with schizophrenia spectrum disorders –A longitudinal qualitative study
ConclusionGenerally, YoGI positively influenced participants’ experiences of their inpatient stay, regarding distress, self- and body awareness, social connectedness, and spiritual wellbeing. However, participants also illuminated necessary adjustments to improve the intervention. YoGI will therefore be adapted and further developed in an iterative process based on a participant involvement approach. The efficacy regarding outcomes and processes needs to be investigated in a future larger-scaled randomized controlled trial. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - February 7, 2023 Category: Psychiatry Source Type: research
IJERPH, Vol. 20, Pages 2891: Association between Problematic Use of Smartphones and Mental Health in the Middle East and North Africa (MENA) Region: A Systematic Review
e Zarrouq Smartphones have become essential components of daily life, and research into the harmful effects of problematic smartphone use (PSU) on mental health is expanding in the Middle East and North Africa (MENA) region. This issue has yet to be synthesized and critically evaluated. To find quantitative observational studies on the relationship between PSU and mental health in the MENA region, we developed a search equation and adapted it for four databases. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed during the selection process. This review included 32 c...
Source: International Journal of Environmental Research and Public Health - February 7, 2023 Category: Environmental Health Authors: Samira Bouazza Samira Abbouyi Soukaina El Kinany Karima El Rhazi Btissame Zarrouq Tags: Review Source Type: research