Heart and Lung Dose as Predictors of Overall Survival in Patients With Locally Advanced Lung Cancer. A National Multicenter Study
CONCLUSIONS: Besides the classic noncardiac risk factors, lung and heart doses had a negative impact on survival, while it is suggested that the left side of the heart is a more radiation dose-sensitive region. The data indicate that overall heart irradiation should be reduced to improve the OS if possible.PMID:38590728 | PMC:PMC10999485 | DOI:10.1016/j.jtocrr.2024.100663 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Agon Olloni Carsten Brink Ebbe Laugaard Lorenzen Stefan Starup Jeppesen Lone Hofmann Charlotte Kristiansen Marianne Marquard Knap Ditte Sloth M øller Lotte Nyg ård Gitte Fredberg Persson Rune Slot Thing Hella Maria Br øgger Sand Axel Diederichsen Tine Source Type: research
Heart and Lung Dose as Predictors of Overall Survival in Patients With Locally Advanced Lung Cancer. A National Multicenter Study
CONCLUSIONS: Besides the classic noncardiac risk factors, lung and heart doses had a negative impact on survival, while it is suggested that the left side of the heart is a more radiation dose-sensitive region. The data indicate that overall heart irradiation should be reduced to improve the OS if possible.PMID:38590728 | PMC:PMC10999485 | DOI:10.1016/j.jtocrr.2024.100663 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Agon Olloni Carsten Brink Ebbe Laugaard Lorenzen Stefan Starup Jeppesen Lone Hofmann Charlotte Kristiansen Marianne Marquard Knap Ditte Sloth M øller Lotte Nyg ård Gitte Fredberg Persson Rune Slot Thing Hella Maria Br øgger Sand Axel Diederichsen Tine Source Type: research
Cancers, Vol. 16, Pages 1449: The Prognostic Impact of the Surgical Margin in Renal Cell Carcinoma Treated with Partial Nephrectomy: A Multi-Center Study
Conclusions: Our study presents further evidence on the negative impact of PSM on recurrence after PN for RCC, highlighting the importance of achieving NSM, thus potentially improving clinical outcomes. A surgical approach was found to be the only predictive factor influencing the risk of PSMs, with a reduced risk observed with robot-assisted laparoscopy. (Source: Cancers)
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Karina Sif S øndergaard Mosholt Mark Aagaard Andreas R øder Nessn Azawi Tags: Article Source Type: research
Which self-reported measures are useful to explore diabetes support needs among adults with diabetes and severe mental illness?
DISCUSSION: PROMs can successfully be constructed in collaboration with this vulnerable population that yield low rates of missing responses.PMID:38584462 | DOI:10.1177/17423953241241762 (Source: Chronic Illness)
Source: Chronic Illness - April 8, 2024 Category: General Medicine Authors: Vibeke Stenov Ingrid Willaing Lene Eide Joensen Lenette Knudsen Gregers Stig Andersen Dorte Lindqvist Hansen Bryan Cleal Source Type: research
Potential Applications of Mitochondrial Therapy with a Focus on Parkinson's Disease and Mitochondrial Transplantation
CONCLUSION: The development of innovative therapeutics for mitochondria-directed treatments in Parkinson's disease may be aided by optimizing mitochondrial dynamics. Many neurological diseases have been studied in animal and cellular models, and it has been found that mitochondrial maintenance can slow the death of neuronal cells. It has been hypothesized that drug therapies for neurodegenerative diseases that focus on mitochondrial dysfunction will help to delay the onset of neuronal dysfunction.PMID:38585467 | PMC:PMC10997929 | DOI:10.34172/apb.2024.019 (Source: Adv Data)
Source: Adv Data - April 8, 2024 Category: Epidemiology Authors: Pranay Wal Ankita Wal Himangi Vig Danish Mahmood Mohd Masih Uzzaman Khan Source Type: research
The importance of the fourth Greek key motif of human γD-crystallin in maintaining lens transparency-the tale told by the tail
CONCLUSIONS: Loss of 39 amino acids in the fourth Greek key motif of human γD-crystallin affects the secondary and tertiary structures and exposes the hydrophobic residues to the solvent. These changes make the molecule less stable, resulting in the formation of light-scattering particles, which explains the importance of the fourth Greek key in the underlying mechanism of opacification and cataract.PMID:38586607 | PMC:PMC10994683 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: VenkataPullaRao Vendra Madhupreetha Thangapandian Source Type: research
Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
CONCLUSIONS: Women with stage I cancer, no chemotherapy, higher comorbidity burden, and history of chronic non-cancer medication use were less likely to adhere to AET. Taking steps to promote adherence in these groups of women may reduce their risk of recurrence.PMID:38589932 | DOI:10.1186/s13058-024-01819-4 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Kirsten M Woolpert Julie A Schmidt Thomas P Ahern Cathrine F Hjorth D óra K Farkas Bent Ejlertsen Lindsay J Collin Timothy L Lash Deirdre P Cronin-Fenton Source Type: research
Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
CONCLUSIONS: Women with stage I cancer, no chemotherapy, higher comorbidity burden, and history of chronic non-cancer medication use were less likely to adhere to AET. Taking steps to promote adherence in these groups of women may reduce their risk of recurrence.PMID:38589932 | DOI:10.1186/s13058-024-01819-4 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Kirsten M Woolpert Julie A Schmidt Thomas P Ahern Cathrine F Hjorth D óra K Farkas Bent Ejlertsen Lindsay J Collin Timothy L Lash Deirdre P Cronin-Fenton Source Type: research
Potential Applications of Mitochondrial Therapy with a Focus on Parkinson's Disease and Mitochondrial Transplantation
CONCLUSION: The development of innovative therapeutics for mitochondria-directed treatments in Parkinson's disease may be aided by optimizing mitochondrial dynamics. Many neurological diseases have been studied in animal and cellular models, and it has been found that mitochondrial maintenance can slow the death of neuronal cells. It has been hypothesized that drug therapies for neurodegenerative diseases that focus on mitochondrial dysfunction will help to delay the onset of neuronal dysfunction.PMID:38585467 | PMC:PMC10997929 | DOI:10.34172/apb.2024.019 (Source: Adv Data)
Source: Adv Data - April 8, 2024 Category: Epidemiology Authors: Pranay Wal Ankita Wal Himangi Vig Danish Mahmood Mohd Masih Uzzaman Khan Source Type: research
Progressive Resistance Training or Neuromuscular Exercise for Hip Osteoarthritis : A Multicenter Cluster Randomized Controlled Trial
CONCLUSION: In patients with hip OA, PRT is not superior to NEMEX for improving functional performance, hip pain, or hip-related QoL.PRIMARY FUNDING SOURCE: Independent Research Fund Denmark.PMID:38588540 | DOI:10.7326/M23-3225 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 8, 2024 Category: Internal Medicine Authors: Troels Kjeldsen S øren T Skou Ulrik Dalgas Lisa U T ønning Kim G Ingwersen Sara Birch P ætur M Holm Thomas Frydendal Mette Garval Claus Varnum Bo M Bibby Inger Mechlenburg Source Type: research
Which self-reported measures are useful to explore diabetes support needs among adults with diabetes and severe mental illness?
DISCUSSION: PROMs can successfully be constructed in collaboration with this vulnerable population that yield low rates of missing responses.PMID:38584462 | DOI:10.1177/17423953241241762 (Source: Chronic Illness)
Source: Chronic Illness - April 8, 2024 Category: General Medicine Authors: Vibeke Stenov Ingrid Willaing Lene Eide Joensen Lenette Knudsen Gregers Stig Andersen Dorte Lindqvist Hansen Bryan Cleal Source Type: research
The importance of the fourth Greek key motif of human γD-crystallin in maintaining lens transparency-the tale told by the tail
CONCLUSIONS: Loss of 39 amino acids in the fourth Greek key motif of human γD-crystallin affects the secondary and tertiary structures and exposes the hydrophobic residues to the solvent. These changes make the molecule less stable, resulting in the formation of light-scattering particles, which explains the importance of the fourth Greek key in the underlying mechanism of opacification and cataract.PMID:38586607 | PMC:PMC10994683 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: VenkataPullaRao Vendra Madhupreetha Thangapandian Source Type: research
Which self-reported measures are useful to explore diabetes support needs among adults with diabetes and severe mental illness?
DISCUSSION: PROMs can successfully be constructed in collaboration with this vulnerable population that yield low rates of missing responses.PMID:38584462 | DOI:10.1177/17423953241241762 (Source: Chronic Illness)
Source: Chronic Illness - April 8, 2024 Category: General Medicine Authors: Vibeke Stenov Ingrid Willaing Lene Eide Joensen Lenette Knudsen Gregers Stig Andersen Dorte Lindqvist Hansen Bryan Cleal Source Type: research
Progressive Resistance Training or Neuromuscular Exercise for Hip Osteoarthritis : A Multicenter Cluster Randomized Controlled Trial
CONCLUSION: In patients with hip OA, PRT is not superior to NEMEX for improving functional performance, hip pain, or hip-related QoL.PRIMARY FUNDING SOURCE: Independent Research Fund Denmark.PMID:38588540 | DOI:10.7326/M23-3225 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 8, 2024 Category: Internal Medicine Authors: Troels Kjeldsen S øren T Skou Ulrik Dalgas Lisa U T ønning Kim G Ingwersen Sara Birch P ætur M Holm Thomas Frydendal Mette Garval Claus Varnum Bo M Bibby Inger Mechlenburg Source Type: research
The importance of the fourth Greek key motif of human γD-crystallin in maintaining lens transparency-the tale told by the tail
CONCLUSIONS: Loss of 39 amino acids in the fourth Greek key motif of human γD-crystallin affects the secondary and tertiary structures and exposes the hydrophobic residues to the solvent. These changes make the molecule less stable, resulting in the formation of light-scattering particles, which explains the importance of the fourth Greek key in the underlying mechanism of opacification and cataract.PMID:38586607 | PMC:PMC10994683 (Source: Molecular Vision)
Source: Molecular Vision - April 8, 2024 Category: Molecular Biology Authors: VenkataPullaRao Vendra Madhupreetha Thangapandian Source Type: research
