A method for precisely timed, on-demand intracranial stimulation using the RNS device
While deep brain stimulation has become a cornerstone treatment for movement disorders, randomized controlled trials for diseases with complex cognitive and behavioral deficits, including Alzheimer's Disease and depression, have not demonstrated efficacy [1,2]. In these trials, stimulation was provided in a continuous, open-loop fashion. However, brain activity for higher-order cognitive processes, including learning and decision-making, has been extensively demonstrated to occur during short, precisely regulated epochs [3,4]. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 27, 2024 Category: Neurology Authors: Edward R. Bader, Alexis D. Boro, Nathaniel J. Killian, Emad N. Eskandar Source Type: research
Low frequency stimulation for seizure suppression: Identification of optimal targets in the entorhinal-hippocampal circuit
This study explores the efficacy of low-frequency stimulation (LFS) on specific neuronal targets within the entorhinal-hippocampal circuit in a mouse model of MTLE. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 23, 2024 Category: Neurology Authors: Piret Kleis, Enya Paschen, Ute H äussler, Carola A. Haas Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023
CONCLUSIONS: This study provides level III evidence that MER during DBS is a risk factor for ICH. Other risk factors include intraoperative systolic blood pressure > 140 mm Hg, sulcal trajectories, and multiple microelectrode insertions. Avoidance of these risk factors may decrease the rate of ICH.PMID:38518284 | DOI:10.3171/2024.1.JNS232385 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 22, 2024 Category: Neurosurgery Authors: Cletus Cheyuo Artur Vetkas Can Sarica Suneil K Kalia Mojgan Hodaie Andres M Lozano Source Type: research
Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease
Ageing Res Rev. 2023 Dec;92:102097. doi: 10.1016/j.arr.2023.102097. Epub 2023 Oct 28.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease with a global burden that affects more often in the elderly. The basal ganglia (BG) is believed to account for movement disorders in PD. More recently, new findings in the original regions in BG involved in motor control, as well as the new circuits or new nucleuses previously not specifically considered were explored. In the present review, we provide up-to-date information related to movement disorders and modulations in PD, especially from the perspectives of br...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Juan Wang Xiaoting Wang Hui Li Limin Shi Ning Song Junxia Xie Source Type: research
Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease
Ageing Res Rev. 2023 Dec;92:102097. doi: 10.1016/j.arr.2023.102097. Epub 2023 Oct 28.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease with a global burden that affects more often in the elderly. The basal ganglia (BG) is believed to account for movement disorders in PD. More recently, new findings in the original regions in BG involved in motor control, as well as the new circuits or new nucleuses previously not specifically considered were explored. In the present review, we provide up-to-date information related to movement disorders and modulations in PD, especially from the perspectives of br...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Juan Wang Xiaoting Wang Hui Li Limin Shi Ning Song Junxia Xie Source Type: research
Protocol for a scoping review of factors associated with disparities in clinical provision of deep brain stimulation
Introduction
Deep brain stimulation (DBS) can be used to treat several neurological and psychiatric conditions such as Parkinson’s disease, epilepsy and obsessive-compulsive disorder; however, limited work has been done to assess the disparities in DBS access and implementation. The goal of this scoping review is to identify sources of disparity in the clinical provision of DBS.
Methods and analysis
A scoping review will be conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-extension for Scoping Reviews methodology. Relevant studies will be identified from databases including M...
Source: BMJ Open - March 21, 2024 Category: General Medicine Authors: Abramson, T., Aguero, R., Arizpe, A., Frank, A., Kang, S., Mason, X. Tags: Open access, Neurology Source Type: research
The role of genetics in the treatment of dystonia with deep brain stimulation: Systematic review and Meta-analysis
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions that lead to involuntary postures or repetitive movements. Genetic mutations are being increasingly recognized as a cause of dystonia. Deep brain stimulation (DBS) is one of the limited treatment options available. However, there are varying reports on its efficacy in genetic dystonias. This systematic review of the characteristics of genetic dystonias treated with DBS and their outcomes aims to aid in the evaluation of eligibility for such treatment. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - March 20, 2024 Category: Neurology Authors: Harini Sarva, Federico Rodriguez-Porcel, Francisco Rivera, Claudio Daniel Gonzalez, Samantha Barkan, Susmit Tripathi, Emilia Gatto, Pedro Garcia Ruiz, Rare Movement Disorders Study Group of the International Parkinsons and Movement Disorders Society Source Type: research
Effects of Deep-Brain Stimulation on Speech: Perceptual and Acoustic Data
CONCLUSIONS: Our data, in general, indicate no-to-minimal changes in speech production ensued from DBS stimulation. The findings are discussed with a focus on large interspeaker variability in PD in terms of their speech characteristics and the potential effects of DBS on speech.PMID:38498664 | DOI:10.1044/2024_JSLHR-23-00511 (Source: Journal of speech, language, and hearing research : JSLHR)
Source: Journal of speech, language, and hearing research : JSLHR - March 18, 2024 Category: Speech-Language Pathology Authors: Yunjung Kim Austin Thompson Ignatius S B Nip Source Type: research
Enhancing Attentional Performance in Parkinson's Disease: The Impact of Combined Deep Brain Stimulation of the Substantia Nigra Pars Reticulata and the Subthalamic Nucleus
: The concomitant stimulation of the subthalamic nucleus and the substantia nigra pars reticulata is a promising approach to improve treatment of refractory axial symptoms in Parkinson`s disease. While dual stimulation of the subthalamic nucleus and the substantia nigra pars reticulata has previously shown beneficial effects on gait, the role of the substantia nigra, a crucial component of the basal ganglia circuitry, in cognitive functions such as attention an executive control remains underexplored. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2024 Category: General Medicine Authors: Julia Thein, Stefanie Linnhoff, J ürgen Voges, Imke Galazky, Tino Zaehle Tags: Brief Observation Source Type: research
Topographical anatomy of the subthalamic region with special interest in the human medial forebrain bundle
CONCLUSIONS: According to this study's findings, the streamlines of the MFB described by tractography arise from the limitations of the diffusion-weighted MRI fiber tracking method and actually correspond to subthalamic fiber bundles, especially the ansa lenticularis and lenticular fasciculus, which erroneously continue in the anterior limb of the internal capsule, toward the prefrontal cortex.PMID:38489821 | DOI:10.3171/2024.1.JNS232066 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - March 15, 2024 Category: Neurosurgery Authors: Cintia Meszaros Peter Kurucz Gabor Baksa Alan Alpar Oliver Ganslandt Sebastian Brandner Laszlo Barany Source Type: research
