Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson ’s disease.
Gait impairment has a major impact on quality of life in patients with Parkinson ’s disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15-30 Hz) may contribute to gait impairment, but the precise dynamics of this oscillatory activity during gait remain unclear. Additionally, auditory cues are known to lead to improvements in gait kinematics in PD. If the neurophysiological mechanisms of this cueing effect were better understood they could be leveraged to treat gait impairments using adaptive Deep Brain Stimulation (aDBS) technologies. (Source: BRAIN STIMULATION: Basic, Translational, ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 16, 2024 Category: Neurology Authors: Chien-Hung Yeh, Yifan Xu, Wenbin Shi, James J. Fitzgerald, Alexander L. Green, Petra Fischer, Huiling Tan, Ashwini Oswal Source Type: research
High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats
Translational Psychiatry, Published online: 15 April 2024; doi:10.1038/s41398-024-02895-yHigh frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats (Source: Translational Psychiatry)
Source: Translational Psychiatry - April 15, 2024 Category: Psychiatry Authors: Libo Zhang Shiqiu Meng Enze Huang Tianqi Di Zengbo Ding Shihao Huang Wenjun Chen Jiayi Zhang Shenghong Zhao Ting Yuwen Yang Chen Yanxue Xue Feng Wang Jie Shi Yu Shi Source Type: research
Impulse Control Disorders in Parkinson ’s Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management
AbstractImpulse control disorders in Parkinson ’s disease are relatively common drug-induced addictive behaviours that are usually triggered by the dopamine agonists pramipexole, ropinirole and rotigotine. This narrative review aimed to provide a comprehensive overview of the current knowledge of impulse control disorders in Parkinson’s dise ase. We summarised the prevalence, clinical features, risk factors and potential underlying mechanisms of impulse control disorders in Parkinson’s disease. Moreover, recent advances in behavioural and imaging characteristics and management strategies are discussed. Early detectio...
Source: CNS Drugs - April 13, 2024 Category: Neurology Source Type: research
Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders
Translational Psychiatry, Published online: 11 April 2024; doi:10.1038/s41398-023-02727-5Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders (Source: Translational Psychiatry)
Source: Translational Psychiatry - April 11, 2024 Category: Psychiatry Authors: Kristina K. Zhang Rafi Matin Carolina Gorodetsky George M. Ibrahim Flavia Venetucci Gouveia Source Type: research
Modeling the volume of tissue activated in deep brain stimulation and its clinical influence: a review
Deep brain stimulation (DBS) is a neuromodulatory therapy that has been FDA approved for the treatment of various disorders, including but not limited to, movement disorders (e.g., Parkinson’s disease and essential tremor), epilepsy, and obsessive-compulsive disorder. Computational methods for estimating the volume of tissue activated (VTA), coupled with brain imaging techniques, form the basis of models that are being generated from retrospective clinical studies for predicting DBS patient outcomes. For instance, VTA models are used to generate target-and network-based probabilistic stimulation maps that play a crucial ...
Source: Frontiers in Human Neuroscience - April 10, 2024 Category: Neuroscience Source Type: research
Deep Brain Stimulation in a 10-Year-Old Child with Pantothenate Kinase-associated Neurodegeneration
Neuropediatrics DOI: 10.1055/s-0044-1785513 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Neuropediatrics)
Source: Neuropediatrics - April 9, 2024 Category: Neurology Authors: Nenadic-Baranasic, Natasa Nemir, Jakob Borovecki, Fran Njiric, Niko Lehman, Ivan Tags: Videos and Images in Neuropediatrics Source Type: research
Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model
Brain Res. 2024 Apr 3:148914. doi: 10.1016/j.brainres.2024.148914. Online ahead of print.ABSTRACTClosed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and br...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Chang Wang Yuting Sun Yanjie Xing Kezhou Liu Kedi Xu Source Type: research
Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model
Brain Res. 2024 Apr 3:148914. doi: 10.1016/j.brainres.2024.148914. Online ahead of print.ABSTRACTClosed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and br...
Source: Brain Research - April 5, 2024 Category: Neurology Authors: Chang Wang Yuting Sun Yanjie Xing Kezhou Liu Kedi Xu Source Type: research
Deep brain stimulation for Alzheimer's disease - current status and next steps
This article explores AD as a manifestation of neurocircuit dysfunction and evaluates deep brain stimulation (DBS) as a potential intervention. Focusing on fornix-targeted stimulation (DBS-f), the article summarizes safety, feasibility, and outcomes observed in phase 1/2 trials, highlighting findings such as cognitive improvement, increased metabolism, and hippocampal growth. Topics for further study include optimization of electrode placement, and the role of stimulation-induced autobiographical-recall. Nucleus basalis of Meynert (DBS-NBM) DBS is also discussed and compared with DBS-f. Challenges with both DBS-f and DBS-N...
Source: Expert Review of Medical Devices - April 4, 2024 Category: Medical Devices Authors: Benjamin Davidson Artur Vetkas J ürgen Germann David Tang-Wai Andres M Lozano Source Type: research
Risk factors and intervention of caregiver burden in Parkinson ’s disease: a systematic review and meta-analysis
ConclusionCaregivers of PD patients experienced mild to moderate caregiver burden. Demographic factor, diseased-related factor and negative emotional factor were the risk factors of caregiver burden. Health education and care support for long-term management after DBS surgery should be provided for patients and caregivers to decrease caregiver burden. (Source: Quality of Life Research)
Source: Quality of Life Research - April 4, 2024 Category: Health Management Source Type: research
