Letter of response to “concerns about efficacy of deep brain stimulation (DBS) in centromedian-parafascicular thalamic complex for rapid onset dystonia-parkinsonism (DYT12-ATP1A3)”
We thank Laura CIF and her colleagues very much for their comments on our published paper [1], and they comment on three key aspects of our report: i) the history and phenomenology of the movement disorder/clinical presentation; ii) the choice of the DBS target; iii) DBS settings programming. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 1, 2024 Category: Neurology Authors: Kai-Liang Wang, Ji-Ping Li, Yong-Zhi Shan, Guo-Guang Zhao, Jing-Hong Ma, Adolfo Ramirez-Zamora, Yu-Qing Zhang Source Type: research
Concerns about efficacy of deep brain stimulation (DBS) in centromedian-parafascicular thalamic complex for rapid onset dystonia-parkinsonism (DYT12-ATP1A3)
This article caught our attention given the lack of proven efficacy of both pharmacological an d neurosurgical treatments for alleviating rapid-onset dystonia-parkinsonism phenotype related to ATP1A3 gene pathogenic variants [2], currently referred to as DYT/PARK-ATP1A3 [3]. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 1, 2024 Category: Neurology Authors: Laura Cif, Mayt é Castro Jimenez, Julien F. Bally Source Type: research
A phenomenological model of deep brain stimulation induced finely tuned gamma oscillations in the subthalamic nucleus
We have read the paper of Sermon and colleagues [1] with great intrigue. Given our team's interest in gaining a better understanding of the physiological mechanisms of action of deep brain stimulation [2], we were eager to understand how STN-DBS may replace “pathological” beta oscillations (13–30 Hz) with purportedly “prokinetic” finely tuned gamma (FTG) oscillations (60–90 Hz) [3]. Sermon and colleagues [1] suggest that subharmonic neural entrainment to the stimulation, locked to half the STN-DBS frequency, may contribute to FTG oscillatio ns observed in the cortex. (Source: BRAIN STIMULATION: Basic, Translati...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 1, 2024 Category: Neurology Authors: M. Scherer, D. Crompton, L. Milosevic Source Type: research
Wireless closed-loop deep brain stimulation using microelectrode array probes
J Zhejiang Univ Sci B. 2024 Feb 12:1-21. doi: 10.1631/jzus.B2300400. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of di...
Source: J Zhejiang Univ Sci ... - February 29, 2024 Category: Science Authors: Qianli Jia Yaoyao Liu Shiya Lv Yiding Wang Peiyao Jiao Wei Xu Zhaojie Xu Mixia Wang Xinxia Cai Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Wireless closed-loop deep brain stimulation using microelectrode array probes
J Zhejiang Univ Sci B. 2024 Feb 12:1-21. doi: 10.1631/jzus.B2300400. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of di...
Source: J Zhejiang Univ Sci ... - February 29, 2024 Category: Science Authors: Qianli Jia Yaoyao Liu Shiya Lv Yiding Wang Peiyao Jiao Wei Xu Zhaojie Xu Mixia Wang Xinxia Cai Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Wireless closed-loop deep brain stimulation using microelectrode array probes
J Zhejiang Univ Sci B. 2024 Feb 12:1-21. doi: 10.1631/jzus.B2300400. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of di...
Source: J Zhejiang Univ Sci ... - February 29, 2024 Category: Science Authors: Qianli Jia Yaoyao Liu Shiya Lv Yiding Wang Peiyao Jiao Wei Xu Zhaojie Xu Mixia Wang Xinxia Cai Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Wireless closed-loop deep brain stimulation using microelectrode array probes
J Zhejiang Univ Sci B. 2024 Feb 12:1-21. doi: 10.1631/jzus.B2300400. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of di...
Source: J Zhejiang Univ Sci ... - February 29, 2024 Category: Science Authors: Qianli Jia Yaoyao Liu Shiya Lv Yiding Wang Peiyao Jiao Wei Xu Zhaojie Xu Mixia Wang Xinxia Cai Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Wireless closed-loop deep brain stimulation using microelectrode array probes
J Zhejiang Univ Sci B. 2024 Feb 12:1-21. doi: 10.1631/jzus.B2300400. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of di...
Source: J Zhejiang Univ Sci ... - February 29, 2024 Category: Science Authors: Qianli Jia Yaoyao Liu Shiya Lv Yiding Wang Peiyao Jiao Wei Xu Zhaojie Xu Mixia Wang Xinxia Cai Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control
Annu Rev Neurosci. 2024 Feb 29. doi: 10.1146/annurev-neuro-092823-104810. Online ahead of print.ABSTRACTDeep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie...
Source: Annual Review of Neuroscience - February 29, 2024 Category: Neurology Authors: Aryn H Gittis Roy V Sillitoe Source Type: research
