Improving Medication Management for Inpatients with a Secondary Diagnosis of Parkinson Disease
Am J Nurs. 2024 May 1;124(5):50-57. doi: 10.1097/01.NAJ.0001016384.47848.89. Epub 2024 Apr 25.ABSTRACTPatients who have Parkinson disease require individualized medication regimens to optimize care. A review of the medication management of patients admitted to a tertiary care hospital with a secondary diagnosis of Parkinson disease found significant departures from the patients' home regimen. Medication regimens are often altered by health care teams unfamiliar with Parkinson disease-specific care in order to conform to standard hospital medication orders and administration times, potentially resulting in increased patient...
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Arlene Boudreaux Ryan F Schell Scott D Nelson Fenna Phibbs Jessica Stroh Amanda Fraley Depp Source Type: research
Clinical and Brain Morphometry Predictors of Deep Brain Stimulation Outcome in Parkinson's Disease
This study aimed to evaluate, in addition to clinical predictors, the effect of patients' individual brain topography on DBS outcome. The medical records of 35 PD patients were used to analyze DBS outcomes measured with the following scales: Part III of the Unified Parkinson's Disease Rating Scale (UPDRS-III) off medication at baseline, and at 6-months during medication off and stimulation on, use of anti-parkinsonian medication (LED), Abnormal Involuntary Movement Scale (AIMS) and Non-Motor Symptoms Questionnaire (NMS-Quest). Furthermore, preoperative brain MRI images were utilized to analyze the brain morphology in relat...
Source: Brain Topography - April 25, 2024 Category: Neuroscience Authors: Maija Koivu Aleksi J Sihvonen Johanna Eerola-Rautio K Amande M Pauls Julio Resendiz-Nieves Nuutti Vartiainen Riku Kivisaari Filip Scheperjans Eero Pekkonen Source Type: research
Illustration of the Long-Term Efficacy of Pallidal Deep Brain Stimulation in a Patient with PKAN Dystonia
Pantothenate kinase-associated neurodegeneration (PKAN, PANK2, OMIM ID: 234200) represents the most common subtype of neurodegeneration associated with brain iron accumulation (NBIA). Treatment could be challenging due to the combination of severe motor and nonmotor features. Deep Brain Stimulation (DBS) may be a promising treatment for dystonia in selected PKAN patients [1]; however, due to the rarity of this genetic condition, the long-term efficacy of DBS on symptoms and disease evolution is unclear, as is its impact on patient independence. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 24, 2024 Category: Neurology Authors: Luigi M. Romito, Fabiana Colucci, Giovanna Zorzi, Barbara Garavaglia, Ahmet Kaymak, Alberto Mazzoni, Celeste Panteghini, Nico Golfr è Andreasi, Sara Rinaldo, Vincenzo Levi, Miryam Carecchio, Roberto Eleopra Source Type: research
Severe enduring anorexia nervosa (SE-AN) treatment options and their effectiveness: a review of literature
Conclusions SE-AN patients are predicted to encounter both medical complications and psychological distress of increasing severity that will inevitably affect their quality of life; to our knowledge, research evidence on treatment options for SE-AN remains limited, and the methodological quality of studies is generally low. These findings denote the need to focus future research efforts on effective treatment strategies specific to long-lasting EDs. (Source: Journal of Eating Disorders)
Source: Journal of Eating Disorders - April 23, 2024 Category: Eating Disorders & Weight Management Source Type: research
Surgicogenomics in GBA1-Related Parkinson Disease: Is the Glass Half Full or Half Empty?
Genetic markers have been instrumental in our pursuit to fully understand Parkinson disease (PD), and “surgicogenomics” offers a promising new approach to further improve our decision-making for deep brain stimulation (DBS). But could this emerging knowledge be a game-changer in our clinical practice? So far, expectations seem to exceed applicability. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 23, 2024 Category: Neurology Authors: Philippe A. Salles, Hubert H. Fern ández, Ignacio M. Mata Source Type: research
Real-Time Optimal Synthetic Inversion Recovery Image Selection (RT-OSIRIS) for Deep Brain Stimulation Targeting
AbstractDeep brain stimulation (DBS) is a method of electrical neuromodulation used to treat a variety of neuropsychiatric conditions including essential tremor, Parkinson ’s disease, epilepsy, and obsessive–compulsive disorder. The procedure requires precise placement of electrodes such that the electrical contacts lie within or in close proximity to specific target nuclei and tracts located deep within the brain. DBS electrode trajectory planning has become incr easingly dependent on direct targeting with the need for precise visualization of targets. MRI is the primary tool for direct visualization, and this has led...
Source: Journal of Digital Imaging - April 19, 2024 Category: Radiology Source Type: research
The deep and the deeper: spinal cord and deep brain stimulation for neuropathic pain
Presse Med. 2024 Apr 16:104231. doi: 10.1016/j.lpm.2024.104231. Online ahead of print.ABSTRACTNeuropathic pain occurs in people experiencing lesion or disease affecting the somatosensorial system. It is present in 7% of the general population and may not fully respond to first- and second-line treatments in up to 40% of cases. Neuromodulation approaches are often proposed for those not tolerating or not responding to usual pharmacological management. These approaches can be delivered surgically (invasively) or non-invasively. Invasive neuromodulation techniques were the first to be employed in neuropathic pain. Among them ...
Source: Presse Medicale - April 18, 2024 Category: General Medicine Authors: Pedro Henrique Martins da Cunha Daniel Ciampi de Andrade Source Type: research
Asymptomatic cable twisting in a patient with impending Twiddler syndrome detected during deep brain stimulation surgery for Parkinson's disease: A case report
CONCLUSION: Twiddler's syndrome is a rare complication of DBS. Subclinical risk of cable twisting jeopardizing Twiddler's syndrome is rarely detected without clinical indications of hardware failure. Neurosurgeons should be cognizant of and regularly monitor the implanted device in case serious complications occur.PMID:38628532 | PMC:PMC11021058 | DOI:10.25259/SNI_844_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Galih Indra Permana Takashi Morishita Hideaki Tanaka Ryuji Matsushita Hiromasa Kobayashi Hiroshi Abe Source Type: research
Asymptomatic cable twisting in a patient with impending Twiddler syndrome detected during deep brain stimulation surgery for Parkinson's disease: A case report
CONCLUSION: Twiddler's syndrome is a rare complication of DBS. Subclinical risk of cable twisting jeopardizing Twiddler's syndrome is rarely detected without clinical indications of hardware failure. Neurosurgeons should be cognizant of and regularly monitor the implanted device in case serious complications occur.PMID:38628532 | PMC:PMC11021058 | DOI:10.25259/SNI_844_2023 (Source: Hand Surgery)
Source: Hand Surgery - April 17, 2024 Category: Surgery Authors: Galih Indra Permana Takashi Morishita Hideaki Tanaka Ryuji Matsushita Hiromasa Kobayashi Hiroshi Abe Source Type: research
Asymptomatic cable twisting in a patient with impending Twiddler syndrome detected during deep brain stimulation surgery for Parkinson's disease: A case report
CONCLUSION: Twiddler's syndrome is a rare complication of DBS. Subclinical risk of cable twisting jeopardizing Twiddler's syndrome is rarely detected without clinical indications of hardware failure. Neurosurgeons should be cognizant of and regularly monitor the implanted device in case serious complications occur.PMID:38628532 | PMC:PMC11021058 | DOI:10.25259/SNI_844_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Galih Indra Permana Takashi Morishita Hideaki Tanaka Ryuji Matsushita Hiromasa Kobayashi Hiroshi Abe Source Type: research
Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson ’s disease.
Gait impairment has a major impact on quality of life in patients with Parkinson ’s disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15-30 Hz) may contribute to gait impairment, but the precise dynamics of this oscillatory activity during gait remain unclear. Additionally, auditory cues are known to lead to improvements in gait kinematics in PD. If the neurophysiological mechanisms of this cueing effect were better understood they could be leveraged to treat gait impairments using adaptive Deep Brain Stimulation (aDBS) technologies. (Source: BRAIN STIMULATION: Basic, Translational, ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 16, 2024 Category: Neurology Authors: Chien-Hung Yeh, Yifan Xu, Wenbin Shi, James J. Fitzgerald, Alexander L. Green, Petra Fischer, Huiling Tan, Ashwini Oswal Source Type: research
High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats
Translational Psychiatry, Published online: 15 April 2024; doi:10.1038/s41398-024-02895-yHigh frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats (Source: Translational Psychiatry)
Source: Translational Psychiatry - April 15, 2024 Category: Psychiatry Authors: Libo Zhang Shiqiu Meng Enze Huang Tianqi Di Zengbo Ding Shihao Huang Wenjun Chen Jiayi Zhang Shenghong Zhao Ting Yuwen Yang Chen Yanxue Xue Feng Wang Jie Shi Yu Shi Source Type: research
Impulse Control Disorders in Parkinson ’s Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management
AbstractImpulse control disorders in Parkinson ’s disease are relatively common drug-induced addictive behaviours that are usually triggered by the dopamine agonists pramipexole, ropinirole and rotigotine. This narrative review aimed to provide a comprehensive overview of the current knowledge of impulse control disorders in Parkinson’s dise ase. We summarised the prevalence, clinical features, risk factors and potential underlying mechanisms of impulse control disorders in Parkinson’s disease. Moreover, recent advances in behavioural and imaging characteristics and management strategies are discussed. Early detectio...
Source: CNS Drugs - April 13, 2024 Category: Neurology Source Type: research
