Ambulatory Brain Biomarkers of Chronic Pain: Towards Closed Loop Brain Stimulation
This study aimed to identify real-world brain biomarkers of chronic pain to personalize DBS. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Prasad Shirvalkar, Philip A. Starr, Edward F. Chang Source Type: research
Prefrontal Network Engagement by Deep Brain Stimulation in Limbic Hubs
Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of neuropsychiatric disorders. However, the detailed neurophysiological effects of stimulation to these hubs and the underlying phenotypical differences in behavior following stimulation are largely unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Anusha Allawala, Stephanie Vartany, Kelly Bijanki, Denise Oswalt, Raissa Mathura, Joshua Adkinson, Garrett Banks, Megan Frankowski, Sanjay Mathew, Wayne Goodman, David Borton, Sameer Sheth Source Type: research
Neuromodulatory Disruption of Pathological Circadian Neural Rhythms Predicts Clinical Response in OCD
Deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) achieves clinical benefit in 66% of treatment-resistant patients. However, there is still a lack of a fundamental understanding of the neurophysiological basis of the relationship between OCD behavior and neural activity. Recent advances in surgical neuromodulation have enabled continuous monitoring of neural activity during everyday activities. Here, our goal was to use these passive, continuous recordings to better understand the neurophysiological basis of clinical response after DBS for OCD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nicole Provenza, Sandesh Reddy, Sameer Rajesh, Anthony Allam, Nabeel Diab, Gabriel Reyes, Kalman Katlowitz, Huy Dang, Ricardo Najera, Nisha Giridharan, Garrett Banks, Ben Shofty, Benjamin Hayden, Jeffrey Herron, Eric Storch, Ankit Patel, Wayne Goodman, Sa Tags: Symposium Source Type: research
152. Deep Brain Stimulation for Treatment-Resistant Depression Changes Plasma Metabolic Markers
Treatment-refractory depression (TRD) occurs in approximately 30-35% of depression patients. As TRD persists, its burden increases exponentially, with impairments in functional and social functioning, loss of quality of life, and a higher risk of suicide. Deep brain stimulation (DBS) is emerging as a potential therapy. However, there is no objective biomarker that can predict clinical response. Here we examine whether metabolic/mitochondrial markers can predict treatment response in refractory depression patients receiving DBS to the medial forebrain bundle (slMFB). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Rafaela Carneiro Cordeiro, Franscisco Eliclecio Rodrigues da Silva, Bashar Asir, Giovana Zunta-Soares, Albert J. Fenoy, Jair Soares, Joao Quevedo, Giselli Scaini Source Type: research
268. Subcallosal Cingulate Deep Brain Stimulation for Depression: Long-Term Safety and Effectiveness Outcomes From a Pooled Analysis of 172 Patients
Deep brain stimulation (DBS) has been investigated clinically for treatment-resistant depression (TRD) using various brain targets. Long-term follow-up (LTFU) data from BROADEN, a randomized controlled trial investigating subcallosal cingulate (SCC) DBS for TRD, demonstrated sustained improvement in depressive symptoms, prompting further investigation of DBS as a therapeutic option. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lyndahl Himes, Helen Mayberg, Mustafa Husain, Paul Holtzheimer, Andres Lozano, Sidney H. Kennedy, Robert Gross, Brian Harris Kopell, Martijn Figee, Konstantin Slavin, Julie Pilitsis, Joseph Neimat, Clement Hamani, Nader Pouratian, Peter Giacobbe, Alon Mog Source Type: research
267. Clinical and Functional Efficacy of Long-Term Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression
Deep brain stimulation (DBS) is an investigational treatment for patients with treatment resistant depression (TRD). Short term clinical effects and safety of subcallosal cingulate (SCC) DBS in TRD have been well documented. Since DBS is an invasive and expensive treatment, independent and replicable data on long term clinical /functional efficacy of SCC-DBS are needed for clinical consideration. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Rajamannar Ramasubbu, Hadi Hassan, Chenhui Hao, Aaron Mackie, Zelma Kiss Source Type: research
329. Converging Evidence for Suppression of Default Mode Network in Deep Brain Stimulation for Obsessive-Compulsive Disorder
Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is a treatment for severe, refractory obsessive-compulsive disorder (OCD). However, the underlying circuit mechanism of DBS for OCD still remains unclear. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Natalya Slepneva, Genevieve Basich-Pease, Adam Frank, Tenzin Norbu, Leo Sugrue, Paul Larson, Philip A. Starr, Melanie Morrison, A Moses Lee Source Type: research
503. Precision Deep Brain Stimulation Targeting for Obsessive-Compulsive Disorder Based on Tractography
Deep brain stimulation (DBS) in the anterior limb of the internal capsule (ALIC) is an effective treatment for obsessive-compulsive disorder (OCD). However, without a clear anatomical stimulation target within the complex ALIC region, clinical benefits are variable and require long trial-and-error periods of parameter optimization. To facilitate ALIC DBS scalability and clinical implementation, we report a method for precision ALIC DBS targeting using patient-specific tractography. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Martijn Figee, Ki Sueng Choi, Alba Segura Amil, Andrew Smith, Helen Mayberg, Brian Harris Kopell Source Type: research
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.PMID:38682230 | DOI:10.31083/j.jin2304084 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sydney G Hillan Anders J Asp Leena B Pramanik Aarushi A Mukerjee Carter B Mulder Wendy D Lujan Jodi L Silvernail Su-Youne Chang Suelen L Boschen J Luis Lujan Source Type: research
Protocol for combined N-of-1 trials to assess cerebellar neurostimulation for movement disorders in children and young adults with dyskinetic cerebral palsy
Movement and tone disorders in children and young adults with cerebral palsy are a great source of disability. Deep brain stimulation (DBS) of basal ganglia targets has a major role in the treatment of isolate... (Source: BMC Neurology)
Source: BMC Neurology - April 29, 2024 Category: Neurology Authors: M San Luciano, C R Oehrn, S S Wang, J S Tolmie, A Wiltshire, R E Graff, J Zhu and P A Starr Tags: Study Protocol Source Type: research
