Risk factors and intervention of caregiver burden in Parkinson ’s disease: a systematic review and meta-analysis
ConclusionCaregivers of PD patients experienced mild to moderate caregiver burden. Demographic factor, diseased-related factor and negative emotional factor were the risk factors of caregiver burden. Health education and care support for long-term management after DBS surgery should be provided for patients and caregivers to decrease caregiver burden. (Source: Quality of Life Research)
Source: Quality of Life Research - April 4, 2024 Category: Health Management Source Type: research
Pallidal deep brain stimulation for patients with myoclonus-dystonia without SGCE mutations
ConclusionsGPi-DBS is effective for treating myoclonus-dystonia in patients with and withoutSGCE mutations. GPi-DBS should be considered as a treatment option for myoclonus-dystonia withoutSGCE mutations. (Source: Journal of Neurology)
Source: Journal of Neurology - April 4, 2024 Category: Neurology Source Type: research
Fine-Tuning the Brain: The Role of Local Field Potentials in DBS Programming
Since its introduction in 1987, Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus (GPi) has become an established surgical treatment for patients with Parkinson ’s disease (PD) who suffer from medically refractory tremor or motor fluctuations. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 4, 2024 Category: Neurology Authors: Mustafa S. Siddiqui, Zoltan Mari Source Type: research
Risk factors and intervention of caregiver burden in Parkinson ’s disease: a systematic review and meta-analysis
ConclusionCaregivers of PD patients experienced mild to moderate caregiver burden. Demographic factor, diseased-related factor and negative emotional factor were the risk factors of caregiver burden. Health education and care support for long-term management after DBS surgery should be provided for patients and caregivers to decrease caregiver burden. (Source: Quality of Life Research)
Source: Quality of Life Research - April 4, 2024 Category: Health Management Source Type: research
Successful treatment of cranial dystonia using a Zolpidem+Melatonin combination: A video case-series
Cranial dystonias (CrD) are challenging to treat. Oral pharmacotherapy is often sub-optimal, while delicate anatomy and limited availability of skilled botulinum toxin injectors makes this approach risky, and often difficult to access; neurosurgical options e.g. deep brain stimulation, are high-risk in the elderly populations most affected.We observed significant improvement in CrD in 2 patients prescribed Zolpidem/Melatonin combination treatment for insomnia, and therefore trialled this treatment in a further 4 patients with CrD. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 2, 2024 Category: Neurology Authors: Narendrakumar H. Barad, Eoin Mulroy Tags: Clinical short communication Source Type: research
Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata
Neurobiol Dis. 2024 Mar 30:106490. doi: 10.1016/j.nbd.2024.106490. Online ahead of print.ABSTRACTThe auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear. We administered an auditory OB task while recording single unit activity (35 units) and local field potentials (57 recordings) from the subthalamic nucleus and substantia nigra pars reticulata of 30 patients with Parkinson's disease undergoing deep brain stimulation surgery. We found tone modulated and oddball modu...
Source: Neurobiology of Disease - April 1, 2024 Category: Neurology Authors: Dallas Leavitt Frhan I Alanazi Tameem M Al-Ozzi Melanie Cohn Mojgan Hodaie Suneil K Kalia Andres M Lozano Luka Milosevic William D Hutchison Source Type: research
Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata
Neurobiol Dis. 2024 Mar 30:106490. doi: 10.1016/j.nbd.2024.106490. Online ahead of print.ABSTRACTThe auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear. We administered an auditory OB task while recording single unit activity (35 units) and local field potentials (57 recordings) from the subthalamic nucleus and substantia nigra pars reticulata of 30 patients with Parkinson's disease undergoing deep brain stimulation surgery. We found tone modulated and oddball modu...
Source: Neurobiology of Disease - April 1, 2024 Category: Neurology Authors: Dallas Leavitt Frhan I Alanazi Tameem M Al-Ozzi Melanie Cohn Mojgan Hodaie Suneil K Kalia Andres M Lozano Luka Milosevic William D Hutchison Source Type: research
Benefits of subthalamic nucleus deep brain stimulation on visually-guided saccades depend on stimulation side and classic paradigm in Parkinson's disease
CONCLUSIONS: Left unilateral and bilateral stimulation both improve the motor outcomes of rightward visually-guided saccades. Additionally, both improve latency, a cognitive-motor outcome, but only in paradigms when attention does not require disengagement from a present stimulus.SIGNIFICANCE: STN-DBS primarily benefits motor and cognitive-motor aspects of visually-guided saccades related to reflexive attentional shifting, with the latter only evident when the fixation-related attentional system is not engaged.PMID:38555666 | DOI:10.1016/j.clinph.2024.03.010 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Miranda J Munoz James L Reilly Gian D Pal Leo Verhagen Metman Sepehr B Sani Joshua M Rosenow Yessenia M Rivera Quentin H Drane Lisa C Goelz Daniel M Corcos Fabian J David Source Type: research
Pallidal multifractal complexity is a new potential physiomarker of dystonia
CONCLUSIONS: Multifractal properties of pallidal neuronal activity serve as indicators of neural dysfunction in dystonia.SIGNIFICANCE: These findings suggest the potential of utilizing multifractal characteristics as predictive factors for the DBS outcome in dystonia.PMID:38555665 | DOI:10.1016/j.clinph.2024.03.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Ulia Semenova Indiko Dzhalagoniya Anna Gamaleya Alexey Tomskiy Aasef G Shaikh Alexey Sedov Source Type: research
Pallidal multifractal complexity is a new potential physiomarker of dystonia
CONCLUSIONS: Multifractal properties of pallidal neuronal activity serve as indicators of neural dysfunction in dystonia.SIGNIFICANCE: These findings suggest the potential of utilizing multifractal characteristics as predictive factors for the DBS outcome in dystonia.PMID:38555665 | DOI:10.1016/j.clinph.2024.03.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Ulia Semenova Indiko Dzhalagoniya Anna Gamaleya Alexey Tomskiy Aasef G Shaikh Alexey Sedov Source Type: research
Benefits of subthalamic nucleus deep brain stimulation on visually-guided saccades depend on stimulation side and classic paradigm in Parkinson's disease
CONCLUSIONS: Left unilateral and bilateral stimulation both improve the motor outcomes of rightward visually-guided saccades. Additionally, both improve latency, a cognitive-motor outcome, but only in paradigms when attention does not require disengagement from a present stimulus.SIGNIFICANCE: STN-DBS primarily benefits motor and cognitive-motor aspects of visually-guided saccades related to reflexive attentional shifting, with the latter only evident when the fixation-related attentional system is not engaged.PMID:38555666 | DOI:10.1016/j.clinph.2024.03.010 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Miranda J Munoz James L Reilly Gian D Pal Leo Verhagen Metman Sepehr B Sani Joshua M Rosenow Yessenia M Rivera Quentin H Drane Lisa C Goelz Daniel M Corcos Fabian J David Source Type: research
Benefits of subthalamic nucleus deep brain stimulation on visually-guided saccades depend on stimulation side and classic paradigm in Parkinson's disease
CONCLUSIONS: Left unilateral and bilateral stimulation both improve the motor outcomes of rightward visually-guided saccades. Additionally, both improve latency, a cognitive-motor outcome, but only in paradigms when attention does not require disengagement from a present stimulus.SIGNIFICANCE: STN-DBS primarily benefits motor and cognitive-motor aspects of visually-guided saccades related to reflexive attentional shifting, with the latter only evident when the fixation-related attentional system is not engaged.PMID:38555666 | DOI:10.1016/j.clinph.2024.03.010 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Miranda J Munoz James L Reilly Gian D Pal Leo Verhagen Metman Sepehr B Sani Joshua M Rosenow Yessenia M Rivera Quentin H Drane Lisa C Goelz Daniel M Corcos Fabian J David Source Type: research
Pallidal multifractal complexity is a new potential physiomarker of dystonia
CONCLUSIONS: Multifractal properties of pallidal neuronal activity serve as indicators of neural dysfunction in dystonia.SIGNIFICANCE: These findings suggest the potential of utilizing multifractal characteristics as predictive factors for the DBS outcome in dystonia.PMID:38555665 | DOI:10.1016/j.clinph.2024.03.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Ulia Semenova Indiko Dzhalagoniya Anna Gamaleya Alexey Tomskiy Aasef G Shaikh Alexey Sedov Source Type: research
Pallidal multifractal complexity is a new potential physiomarker of dystonia
CONCLUSIONS: Multifractal properties of pallidal neuronal activity serve as indicators of neural dysfunction in dystonia.SIGNIFICANCE: These findings suggest the potential of utilizing multifractal characteristics as predictive factors for the DBS outcome in dystonia.PMID:38555665 | DOI:10.1016/j.clinph.2024.03.012 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Ulia Semenova Indiko Dzhalagoniya Anna Gamaleya Alexey Tomskiy Aasef G Shaikh Alexey Sedov Source Type: research
Benefits of subthalamic nucleus deep brain stimulation on visually-guided saccades depend on stimulation side and classic paradigm in Parkinson's disease
CONCLUSIONS: Left unilateral and bilateral stimulation both improve the motor outcomes of rightward visually-guided saccades. Additionally, both improve latency, a cognitive-motor outcome, but only in paradigms when attention does not require disengagement from a present stimulus.SIGNIFICANCE: STN-DBS primarily benefits motor and cognitive-motor aspects of visually-guided saccades related to reflexive attentional shifting, with the latter only evident when the fixation-related attentional system is not engaged.PMID:38555666 | DOI:10.1016/j.clinph.2024.03.010 (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Miranda J Munoz James L Reilly Gian D Pal Leo Verhagen Metman Sepehr B Sani Joshua M Rosenow Yessenia M Rivera Quentin H Drane Lisa C Goelz Daniel M Corcos Fabian J David Source Type: research
