Benefits of subthalamic nucleus deep brain stimulation on visually-guided saccades depend on stimulation side and classic paradigm in Parkinson's disease

CONCLUSIONS: Left unilateral and bilateral stimulation both improve the motor outcomes of rightward visually-guided saccades. Additionally, both improve latency, a cognitive-motor outcome, but only in paradigms when attention does not require disengagement from a present stimulus.SIGNIFICANCE: STN-DBS primarily benefits motor and cognitive-motor aspects of visually-guided saccades related to reflexive attentional shifting, with the latter only evident when the fixation-related attentional system is not engaged.PMID:38555666 | DOI:10.1016/j.clinph.2024.03.010

Source: Clinical Neurophysiology - March 31, 2024 Category: Neurology Authors: Miranda J Munoz James L Reilly Gian D Pal Leo Verhagen Metman Sepehr B Sani Joshua M Rosenow Yessenia M Rivera Quentin H Drane Lisa C Goelz Daniel M Corcos Fabian J David Source Type: research