Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease
CONCLUSION: Spatial memory performance, hippocampal neurodegeneration, and serum levels of miR-let-7b and miR-181c were affected by MFB-ICSS under AD-like conditions. Our results validate the MFB as a potential target for DBS and lend support to the use of specific miRNAs as promising biomarkers of the effectiveness of DBS in combatting AD-associated cognitive deficits.PMID:38490646 | PMC:PMC10950362 | DOI:10.1503/jpn.230066 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 15, 2024 Category: Psychiatry Authors: Andrea Riberas-S ánchez Irene Puig-Parnau Laia Vila-Sol és Soleil Garcia-Brito Laura Aldavert-Vera Pilar Segura-Torres Gemma Huguet Elisabet K ádár Source Type: research
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
In this study, we compared the motor rehabilitative effects of deep cerebellar stimulation in two rodent models of cerebral ischemia: a) cortical ischemia; and b) combined striatal and cortical ischemia. All animals underwent the same procedures, including implantation of the electrodes and tethered connections for stimulation. Both experimental groups received four weeks of continuous lateral cerebellar nucleus (LCN) DBS and each was paired with a no stimulation, sham, group. Fine motor function was indexed using the pasta matrix task. Brain tissue was harvested for histology and immunohistochemical analyses. In the corti...
Source: Experimental Neurology - March 14, 2024 Category: Neurology Authors: Hugh H Chan Nicole D Mathews Hemen Khanna Nymisha Mandava Olivia Hogue Andre G Machado Kenneth B Baker Source Type: research
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
In this study, we compared the motor rehabilitative effects of deep cerebellar stimulation in two rodent models of cerebral ischemia: a) cortical ischemia; and b) combined striatal and cortical ischemia. All animals underwent the same procedures, including implantation of the electrodes and tethered connections for stimulation. Both experimental groups received four weeks of continuous lateral cerebellar nucleus (LCN) DBS and each was paired with a no stimulation, sham, group. Fine motor function was indexed using the pasta matrix task. Brain tissue was harvested for histology and immunohistochemical analyses. In the corti...
Source: Experimental Neurology - March 14, 2024 Category: Neurology Authors: Hugh H Chan Nicole D Mathews Hemen Khanna Nymisha Mandava Olivia Hogue Andre G Machado Kenneth B Baker Source Type: research
GPi-DBS-induced brain metabolic activation in cervical dystonia
Conclusions
GPi-DBS increases metabolic activity at the stimulation site and sensorimotor network. The clinical benefit and adverse effects are mediated by modulation of specific networks. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2024 Category: Neurosurgery Authors: Honkanen, E. A., Rönkä, J., Pekkonen, E., Aaltonen, J., Koivu, M., Eskola, O., Eldebakey, H., Volkmann, J., Kaasinen, V., Reich, M. M., Joutsa, J. Tags: Movement disorders Source Type: research
Are patients with GBA-Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort
Conclusions
Evaluation of long-term impact of GBA variants in a large Italian DBS-PD cohort supported the role of DBS surgery as a valid therapeutic strategy in GBA-PD, with long-term benefit on motor performance and ICD. Despite the selective worsening of cognitive scores since 3 years post-DBS, the majority of GBA-PD had not developed dementia at 5-year follow-up. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2024 Category: Neurosurgery Authors: Avenali, M., Zangaglia, R., Cuconato, G., Palmieri, I., Albanese, A., Artusi, C. A., Bozzali, M., Calandra-Buonaura, G., Cavallieri, F., Cilia, R., Cocco, A., Cogiamanian, F., Colucci, F., Cortelli, P., Di Fonzo, A., Eleopra, R., Giannini, G., Imarisio, A Tags: Open access Movement disorders Source Type: research
