Gait and speech improvement in one patient following 3-months of adaptive STN-DBS therapy
Background: While conventional subthalamic (STN) deep brain stimulation (cDBS) provides stimulation with constant parameters, current adaptive paradigms (aDBS) modulate the stimulation amplitude based on subthalamic beta power dynamics. The efficacy of long-term aDBS paradigms is currently under study. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: C. Palmisano, L. Borellini, L. Caffi, S. Bonvegna, E. Contaldi, F. Mameli, A. D ’Ammando, M. Arlotti, V. Aloia, L. Rossi, E. Mailland, F. Cogiamanian, S. Barbieri, A. Mazzoni, G. Pezzoli, A. Priori, A.M. Ampollini, S. Marceglia, M. Locatelli, I.U. Isaia Source Type: research
Pregnancy in dystonia or Tourette ’s patients treated with DBS. Four new cases and a review of the literature
Background: Deep Brain Stimulation (DBS) has been demonstrated to improve quality of life in patients with refractory dystonia and Tourette ’s syndrome (TS). Because of the young age at onset of these disorders, and the marked benefit from DBS, pregnancy in patients who have received DBS is becoming a more frequent clinical occurrence, although clear management guidelines are lacking. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Mehanna, A. Tarakad, L.Y. Taneff, E. Furr Stimming Source Type: research
Addressing Brain Circuit Dysfunction Underlying DBS-induced Parkinsonism
Background: Deep Brain Stimulation (DBS) of the Globus Pallidus internus (GPi) is an effective treatment for dystonia - a medical condition characterized by involuntary muscle contractions and postures. However, GPi-DBS may sometimes lead to stimulation-related side effects, such as parkinsonism. This work aimed to clarify the neural circuits underlying this symptom and provide data to inform its optimal management. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Martins, R. Barbosa, T. Lampreia, G. Cotovio, F. Faro-Viana, M. Coelho, J. Alves da Silva, M. Mendon ça, A.J. Oliveira-Maia Source Type: research
Predicting the optimal deep brain stimulation contact-level in Parkinson's disease: Insights from local field potentials recorded by the implanted neurostimulator
This study aimed to improve the DBS programming efficiency by predicting the optimal stimulation contact-level(s) based on local field potentials (LFPs) recorded by the implanted DBS system. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Muller, S. van der Gaag, R. Zutt, N.A. van der Gaag, C.F. Hoffmann, M.F. Contarino Source Type: research
Oscillatory subthalamic cell motor responses are associated with clinical characteristics of Parkinson ’s disease
Background: Basal ganglia neuronal motor responses could be potential biomarkers for deep brain stimulation (DBS) improvements and are being studied extensively. Taking into account previous research we hypothesized changes of subthalamic (STN) activity during voluntary movements in Parkinson ’s disease (PD) patients as follows: the first movement of a series (initiation of a motor program) should lead to alpha activity (7-12 Hz) desynchronisation on a time scale of 2 seconds and each of the rest movements (inside motor program) should desynchronize low-beta activity (12-20 Hz) for a t ime period of 500 ms. (Source: Park...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Nezvinskiy, E. Belova, A. Gamaleya, A. Tomskiy, A. Sedov Source Type: research
Gender, Race and Socioeconomic Disparities on Initiation of Surgical Device-Aided Therapies (DATs) Among Medicare Beneficiaries with advanced Parkinson ’s Disease (aPD)
The objective of this study is to determine the impact of demographic and clinical characteristics, geographic factors, and social determinants of heal th on initiation of a surgical device-aided therapy (DAT) among people with advanced Parkinson’s Disease (PwaPD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H.H. Fernandez, I. Malaty, M. Soileau, Z.T. Baldwin, C.H. Yan, L. Kandukuri, J. Schinkel, C. Teigland, Z. Pulungan, M.B. Shah, P. Kukreja, A. Hambrick, A. Shewale, J. Jimenez Shahed Source Type: research
Influence of electrode distance from target and stimulation current on the effect of STN-DBS
Background: Not all patients with Parkinson ’s Disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) obtain the same benefit. Preoperative indicators are often used to predict the amount of benefit, but accurate lead placement with respect to the planned target is also relevant (Girgis et al., 2020; Kremer et al., 2 019; Nickl et al., 2019). In theory, small deviations from the target location can be corrected for by adapting stimulation parameters and increasing the field of stimulation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E.A.M.Y. Rouleau, Z.A. Vallinga, V.J. Geraedts, C.F.E. Hoffmann, R. Zutt, N.A. van der Gaag, M.F. Contarino Source Type: research
Objective clinical registration of tremor, bradykinesia, and rigidity during awake stereotactic neurosurgery
Background: Tremor, bradykinesia, and rigidity are incapacitating motor signs that can be suppressed with Deep Brain Stimulation (DBS), and ablative surgery (e.g. thalamotomy, pallidotomy). Although clinicians traditionally rely on clinical rating scales for intraoperative evaluation of these signs during awake stereotactic neurosurgery, they have a relatively high inter-rater variability which is also influenced by the experience of the raters. Objective intraoperative assessments of tremor, bradykinesia, and rigidity (e.g. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Smid, Z.T. Dominguez Vega, T. van Laar, D.L.M. Oterdoom, A.R. Absalom, M.E. van Egmond, G. Drost, J.M.C. van Dijk Source Type: research
Quantifying local field potential dynamics with amplitude and frequency stability between ON and OFF medication and stimulation in Parkinson's disease
In this study, we proposed a method based on the stationary wavelet transform to quantify the amplitude and frequency stability of subthalamic nucleus beta oscillations and evaluated the method using simulation and real data for Parkinson's disease patients. The results suggest that the amplitude and frequency stability quantification has enhanced sensitivity in distinguishing pathological conditions in Parkinson's disease patients. Our quantification shows the benefit of combining frequency stability information with amplitude and provides a new potential feedback signal for adaptive deep brain stimulation.PMID:38685358 |...
Source: Neurobiology of Disease - April 30, 2024 Category: Neurology Authors: Xuanjun Guo Shenghong He Xinyi Geng Pan Yao Christoph Wiest Yingnan Nie Huiling Tan Shouyan Wang Source Type: research
Quantifying local field potential dynamics with amplitude and frequency stability between ON and OFF medication and stimulation in Parkinson's disease
In this study, we proposed a method based on the stationary wavelet transform to quantify the amplitude and frequency stability of subthalamic nucleus beta oscillations and evaluated the method using simulation and real data for Parkinson's disease patients. The results suggest that the amplitude and frequency stability quantification has enhanced sensitivity in distinguishing pathological conditions in Parkinson's disease patients. Our quantification shows the benefit of combining frequency stability information with amplitude and provides a new potential feedback signal for adaptive deep brain stimulation.PMID:38685358 |...
Source: Neurobiology of Disease - April 30, 2024 Category: Neurology Authors: Xuanjun Guo Shenghong He Xinyi Geng Pan Yao Christoph Wiest Yingnan Nie Huiling Tan Shouyan Wang Source Type: research
19. Neuro-Computational Mechanism of Enhancing Flexible Cognitive Control Through Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum
Decision-making in Depression and OCD is characterized by indecisiveness and impaired conflict resolution, a component of cognitive control. Recent evidence reports that deep brain stimulation of the ventral capsule/ventral striatum (VCVS DBS) enhances cognitive control but its underlying neuro-computational mechanism is unclear. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jaejoong Kim, Alik Widge Source Type: research
Device-Based Therapies: Unpacking the Past, Rebuilding the Present, and Re-Tooling the Future of Neuromodulation in Psychiatry
From the early days of electroconvulsive therapy (ECT) to next generation technologies like closed-loop deep brain stimulation, device-based therapies have transformed the landscape of psychiatric research and practice. ECT often works when medications fail in our most severely ill patients, but it also carries a risk of memory loss. While ECT dosing has evolved to mitigate this risk, recent work unpacking the contributions of the electric field and the seizure to the therapeutic effects and adverse side effects may be key to developing safer seizure therapies for the future. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sarah H. Lisanby Source Type: research
Causal Network Localization of Novel Brain Stimulation Targets for Transdiagnostic Trait Anxiety
Transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) can treat some neuropsychiatric disorders, but anatomical targets for anxiety remain unclear. Lesion network mapping can be used to optimize existing targets but has not been shown to identify novel effective targets. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Shan Siddiqi, Julian Klingbeil, Ian Kratter, Daniel Blumberger, Mark George, Jordan Grafman, Alvaro Pascual-Leone, R. Mark Richardson, Pratik Talati, Fidel Vila-Rodriguez, Jonathan Downar, Tamara Hershey, Kevin Black Source Type: research
Electroconvulsive Therapy-Induced Volumetric Brain Changes Converge on a Common Causal Circuit in Depression
Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Miklos Argyelan, Zhi-De Deng, Olga Therese Ousdal, Leif Oltedal, GEMRIC, Georgios Petrides, Anil Malhotra, Christopher Abbott Tags: SYMPOSIUM Source Type: research
Developing and Validating Marker of Treatment Response for Subcallosal Cingulate Deep Brain Stimulation
Patients with treatment-resistant depression (TRD) have been successfully treated through deep brain stimulation (DBS) of the subcallosal cingulate cortex (SCC). However, current clinical assessments of depression severity are not reliable as they are susceptible to extraneous factors unrelated to core depression. Thus there is a need for objective brain-based biomarkers to support clinical decisions such as stimulation dose adjustment or augmentation with therapy. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sankaraleengam Alagapan, Elif Ceren Fitoz, Patricio Riva Posse, Martijn Figee, Helen Mayberg, Christopher Rozell Source Type: research
