Are patients with GBA-Parkinson disease good candidates for deep brain stimulation? A longitudinal multicentric study on a large Italian cohort

Conclusions
Evaluation of long-term impact of GBA variants in a large Italian DBS-PD cohort supported the role of DBS surgery as a valid therapeutic strategy in GBA-PD, with long-term benefit on motor performance and ICD. Despite the selective worsening of cognitive scores since 3 years post-DBS, the majority of GBA-PD had not developed dementia at 5-year follow-up.

Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2024 Category: Neurosurgery Authors: Avenali, M., Zangaglia, R., Cuconato, G., Palmieri, I., Albanese, A., Artusi, C. A., Bozzali, M., Calandra-Buonaura, G., Cavallieri, F., Cilia, R., Cocco, A., Cogiamanian, F., Colucci, F., Cortelli, P., Di Fonzo, A., Eleopra, R., Giannini, G., Imarisio, A Tags: Open access Movement disorders Source Type: research