Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach : German version
CONCLUSION: The working group selected 4 leading, evidence-based treatments for cLBP to be tested in the clinical trial and for use in routine clinical treatment. These treatments include (1) duloxetine, (2) acceptance and commitment therapy, (3) a classification-based exercise and manual therapy intervention, and (4) a self-management approach. These interventions each had a moderate to high level of evidence to support a therapeutic effect and were from different therapeutic classes.PMID:38381187 | DOI:10.1007/s00482-024-00798-x (Source: Schmerz)
Source: Schmerz - February 21, 2024 Category: Anesthesiology Authors: Matthew C Mauck Aileen F Aylward Chloe E Barton Brandon Birckhead Timothy Carey Diane M Dalton Aaron J Fields Julie Fritz Afton L Hassett Anna Hoffmeyer Sara B Jones Samuel A McLean Wolf E Mehling Conor W O'Neill Michael J Schneider David A Williams Patri Source Type: research
Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach : German version
CONCLUSION: The working group selected 4 leading, evidence-based treatments for cLBP to be tested in the clinical trial and for use in routine clinical treatment. These treatments include (1) duloxetine, (2) acceptance and commitment therapy, (3) a classification-based exercise and manual therapy intervention, and (4) a self-management approach. These interventions each had a moderate to high level of evidence to support a therapeutic effect and were from different therapeutic classes.PMID:38381187 | DOI:10.1007/s00482-024-00798-x (Source: Schmerz)
Source: Schmerz - February 21, 2024 Category: Anesthesiology Authors: Matthew C Mauck Aileen F Aylward Chloe E Barton Brandon Birckhead Timothy Carey Diane M Dalton Aaron J Fields Julie Fritz Afton L Hassett Anna Hoffmeyer Sara B Jones Samuel A McLean Wolf E Mehling Conor W O'Neill Michael J Schneider David A Williams Patri Source Type: research
Duloxetine as an Analgesic in Patients Who Do Not Have Central Sensitivity Undergoing Single-Sitting, Bilateral Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized, Placebo-Controlled Trial
Pain control and patient satisfaction after total knee arthroplasty (TKA) have room for improvement. While studies have reported better analgesic outcomes with antidepressants like duloxetine in patients who do not have central sensitivity, we undertook this trial to determine the short and midterm analgesic role of low-dose duloxetine in patients who do not have central sensitivity. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - February 12, 2024 Category: Orthopaedics Authors: Amyn M. Rajani, Anmol RS. Mittal, Vishal U. Kulkarni, Megha Desai, Rishab Dubey, Khushi Rajani, Kashish Rajani Source Type: research
Duloxetine as an Analgesic in Patients Who Do Not Have Central Sensitivity Undergoing Single-Setting, Bilateral Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized, Placebo-Controlled Trial
Pain control and patient satisfaction after total knee arthroplasty (TKA) have room for improvement. While studies have reported better analgesic outcomes with antidepressants like duloxetine in patients who do not have central sensitivity (CS), we undertook this trial to determine the short and midterm analgesic role of low-dose duloxetine in patients who do not have CS. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - February 12, 2024 Category: Orthopaedics Authors: Amyn M. Rajani, Anmol R.S. Mittal, Vishal U. Kulkarni, Megha K. Desai, Rishab R. Dubey, Khushi A. Rajani, Kashish A. Rajani Source Type: research
Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research
Visual Hallucinations After Duloxetine Use
Prim Care Companion CNS Disord. 2024 Jan 25;26(1):23cr03595. doi: 10.4088/PCC.23cr03595.NO ABSTRACTPMID:38277643 | DOI:10.4088/PCC.23cr03595 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - January 26, 2024 Category: Primary Care Authors: Daniela Oliveira Martins Mauro Pinho Filipa Caldas Eduardo Gomes Pereira Source Type: research
Urinary symptoms change and quality of life after robotic radical prostatectomy: a secondary analysis of a randomized controlled trial
To present the patient-reported QoL outcomes from a prospective, randomized controlled trial comparing the use of pelvic floor muscle training (PFMT) and duloxetine after robot-assisted radical prostatectomy (RARP). (Source: Urology)
Source: Urology - January 26, 2024 Category: Urology & Nephrology Authors: Rafael Tourinho-Barbosa, Rafael Sanchez-Salas, Arjun Sivaraman, Rafael Castilho Borges, Luigi Candela, Lucas Teixeira Batista, Nathalie Cathala, Annick Mombet, Giancarlo Marra, Lara Rodriguez Sanchez, Chahrazad Bey Boumezrag, Camille Lanz, Petr Macek, Xav Source Type: research
Low-Dose Naltrexone Improves post-COVID-19 condition Symptoms
Clin Ther. 2024 Jan 23:S0149-2918(24)00003-1. doi: 10.1016/j.clinthera.2023.12.009. Online ahead of print.ABSTRACTPURPOSE: Treatments for myalgic encephalomyelitis and chronic fatigue syndrome can be adapted for post-COVID-19 condition. Our aim was to compare treatments in patients from our post-COVID-19 clinic.METHODS: We conducted a retrospective cohort study and included consecutive patients enrolled in our post-COVID-19 clinic. We included patients who received low-dose naltrexone, amitriptyline, duloxetine, and physical therapy, and evaluated improvements in fatigue, pain, dyspnea, and brain fog recorded in the electr...
Source: Clinical Therapeutics - January 24, 2024 Category: Drugs & Pharmacology Authors: Leonardo Tamariz Elizabeth Bast Nancy Klimas Ana Palacio Source Type: research
Morphine concentrations in fatalities after palliative treatment of acute burn injury
AbstractThe evaluation of a morphine concentration in postmortem blood is routine for a forensic toxicologist. We here report three fatal cases where we found high morphine concentrations with 7.96, 4.30, and 5.82 mg/l in femoral blood that have to be estimated as unusually high. All these individuals died due to severe burn injuries and obtained morphine in the context of their palliative care in the last hours of their lives. According to the autopsy results, the cause of death in case 1 was burn disease with burns of about 90% of the body surface area (BSA), case 2 burn trauma, and case 3 burn shock. Besides morphine,...
Source: International Journal of Legal Medicine - January 17, 2024 Category: Medical Law Source Type: research
Comparing the efficacy of duloxetine and nortriptyline in alleviating the symptoms of functional dyspepsia – a randomized clinical trial
ConclusionWhile both medications demonstrated efficacy, Nortriptyline appeared to be superior in symptom reduction. Duloxetine exhibited more advantages compared to Nortriptyline in addressing anxiety and depression and enhancing the overall quality of life. Also, Duloxetine may have a noteworthy impact, contributing to a 20% reduction in FD symptoms by lowering anxiety levels.Clinical trial registrationhttps://en.irct.ir/trial/65512. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - January 16, 2024 Category: Psychiatry Source Type: research
Effects of Duloxetine on Gastrointestinal Symptoms, Depression, Anxiety, Stress, and Quality of Life in Patients with the Moderate-to-Severe Irritable Bowel Syndrome
CONCLUSION: Duloxetine is probably helpful for reducing anxiety, stress, and the severity of symptoms in IBS patients. It also could increase the quality of life in patients.PMID:38192887 | PMC:PMC10772789 | DOI:10.4103/abr.abr_379_21 (Source: Biomed Res)
Source: Biomed Res - January 9, 2024 Category: Research Authors: Mohammad Reza Sharbafchi Hamid Afshar Zanjani Zahra Saneian Awat Feizi Hamed Daghaghzadeh Peyman Adibi Source Type: research
Effects of Duloxetine on Gastrointestinal Symptoms, Depression, Anxiety, Stress, and Quality of Life in Patients with the Moderate-to-Severe Irritable Bowel Syndrome
CONCLUSION: Duloxetine is probably helpful for reducing anxiety, stress, and the severity of symptoms in IBS patients. It also could increase the quality of life in patients.PMID:38192887 | PMC:PMC10772789 | DOI:10.4103/abr.abr_379_21 (Source: Adv Data)
Source: Adv Data - January 9, 2024 Category: Epidemiology Authors: Mohammad Reza Sharbafchi Hamid Afshar Zanjani Zahra Saneian Awat Feizi Hamed Daghaghzadeh Peyman Adibi Source Type: research
What Is the Role of a Periarticular Injection for Knee Arthroplasty Patients Receiving a Multimodal Analgesia Regimen Incorporating Adductor Canal and Infiltration Between the Popliteal Artery and Capsule of the Knee Blocks? A Randomized Blinded Placebo-Controlled Noninferiority Trial
CONCLUSIONS: For TKA patients given a comprehensive analgesic protocol, use of saline PAI did not demonstrate noninferiority compared to active PAI. Neither the primary nor any secondary outcomes demonstrated superiority for active PAI, however. As we cannot claim either technique to be better or worse, there remains flexibility for use of either technique.PMID:38190339 | DOI:10.1213/ANE.0000000000006805 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - January 8, 2024 Category: Anesthesiology Authors: Jacques T YaDeau Fred D Cushner Geoffrey Westrich Justas Lauzadis Richard L Kahn Yi Lin Enrique A Goytizolo David J Mayman Kethy M Jules-Elysee Ejiro Gbaje Douglas E Padgett Source Type: research
Enhancing antidepressant safety surveillance: comparative analysis of adverse drug reaction signals in spontaneous reporting and healthcare claims databases
Conclusion: NHIC exhibited greater capability in detecting ADR signals associated with antidepressant use, encompassing unlabeled ADR signals, compared to KAERS. NHIC also demonstrated greater potential for identifying less common ADRs. Further investigation is needed for signals detected exclusively in NHIC but not covered by labeling information. This study underscores the value of integrating different sources of data, offering substantial regulatory insights and enriching the scope of pharmacovigilance. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 8, 2024 Category: Drugs & Pharmacology Source Type: research
Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California
Conclusions
Compared with therapeutic alternatives, nortriptyline was found to represent a lower risk for falls, fractures and syncope, versus comparator medications, except for a few instances that had equivalent risk. The risk for these adverse events from paroxetine was comparable to the alternative medications. (Source: BMJ Open)
Source: BMJ Open - December 28, 2023 Category: General Medicine Authors: George, M. M., Deamer, R. L., Do, D. Tags: Open access, Geriatric medicine Source Type: research
