Venlafaxine aggravating interstitial pneumonia: A case report
Int J Clin Pharmacol Ther. 2023 Nov 16. doi: 10.5414/CP204459. Online ahead of print.ABSTRACTA 70-year-old male taking venlafaxine for depression developed interstitial pneumonia and was admitted with shortness of breath and dyspnea. A computed tomography (CT) chest scan showed diffuse multiple lung lesions in both lungs, suggesting interstitial changes with inflammation or exudation. Compared with the CT chest scan 1 month earlier, there were significant progresses and new findings. The clinical diagnosis was interstitial pneumonia with pulmonary infection. The patient had been treated with fluvoxamine 100 mg/day, duloxet...
Source: Clinical Pharmacology and Therapeutics - November 16, 2023 Category: Drugs & Pharmacology Authors: Xia Wu Lutao Zhang Chuanping Wang Source Type: research
Venlafaxine aggravating interstitial pneumonia: A case report
Int J Clin Pharmacol Ther. 2023 Nov 16. doi: 10.5414/CP204459. Online ahead of print.ABSTRACTA 70-year-old male taking venlafaxine for depression developed interstitial pneumonia and was admitted with shortness of breath and dyspnea. A computed tomography (CT) chest scan showed diffuse multiple lung lesions in both lungs, suggesting interstitial changes with inflammation or exudation. Compared with the CT chest scan 1 month earlier, there were significant progresses and new findings. The clinical diagnosis was interstitial pneumonia with pulmonary infection. The patient had been treated with fluvoxamine 100 mg/day, duloxet...
Source: International Journal of Clinical Pharmacology and Therapeutics - November 16, 2023 Category: Drugs & Pharmacology Authors: Xia Wu Lutao Zhang Chuanping Wang Source Type: research
The simultaneous measurement of atomoxetine, venlafaxine, and duloxetine in actual water and biological samples requires the creation of a unique magnetic dispersive micro solid phase extraction sorbent based on MOF-on-MOF
. (Source: International Journal of Environmental Analytical Chemistry)
Source: International Journal of Environmental Analytical Chemistry - November 14, 2023 Category: Chemistry Authors: Aysir AlhmaundeMahboubeh MasrourniaAli JavidDepartment of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran Source Type: research
Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain –related depression by upregulating BDNF/TrkB/CREB signaling pathway
ConclusionEA improves pain and depressive behaviors in CIPD rats, and the mechanism may be related to synaptic plasticity mediated by the BDNF/TrKB/CREB signaling pathway. (Source: Brain and Behavior)
Source: Brain and Behavior - November 10, 2023 Category: Neurology Authors: Pu Yang,
Haiyan Chen,
Tian Wang,
Hong Su,
Jing Li,
Yujun He,
Shengyong Su Tags: ORIGINAL ARTICLE Source Type: research
Antidepressant duloxetine hydrochloride protects against ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation
CONCLUSION: The findings from this study suggest that DH, instead of causing bone mass loss, may assist in alleviating postmenopausal osteoporosis. These results can serve as a reference for the clinical treatment of patients with perimenopausal or postmenopausal depression using antidepressants.PMID:37913736 | DOI:10.1016/j.biopha.2023.115810 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 1, 2023 Category: Drugs & Pharmacology Authors: Weijun Zhou Wenyun Zhou Yonghao Bi Zibin Zhou Zhigao Zhou Shaozhe Chen Gang Xie Zhen Lian Guixin Yuan Guanfeng Yao Source Type: research
Antidepressant duloxetine hydrochloride protects against ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation
CONCLUSION: The findings from this study suggest that DH, instead of causing bone mass loss, may assist in alleviating postmenopausal osteoporosis. These results can serve as a reference for the clinical treatment of patients with perimenopausal or postmenopausal depression using antidepressants.PMID:37913736 | DOI:10.1016/j.biopha.2023.115810 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 1, 2023 Category: Drugs & Pharmacology Authors: Weijun Zhou Wenyun Zhou Yonghao Bi Zibin Zhou Zhigao Zhou Shaozhe Chen Gang Xie Zhen Lian Guixin Yuan Guanfeng Yao Source Type: research
Assessing the efficacy of pelvic floor muscle training and duloxetine on urinary continence recovery following radical prostatectomy: A randomized clinical trial
CONCLUSIONS: PFMT-biofeedback and duloxetine demonstrated limited impact in improving UCR after RP. Diligent NVB preservation, along with preoperative patient and disease characteristics, are the primary determinants for early UCR.PMID:37904330 | DOI:10.1002/pros.24634 (Source: Cancer Control)
Source: Cancer Control - October 31, 2023 Category: Cancer & Oncology Authors: Rafael Sanchez-Salas Rafael Tourinho-Barbosa Arjun Sivaraman Rafael Castilho Borges Luigi Candela Nathalie Cathala Annick Mombet Giancarlo Marra Lara Rodriguez Sanchez Chahrazad Bey Boumezrag Camille Lanz Petr Macek Fernando Korkes Xavier Cathelineau Source Type: research
Bicarbonate buffer dissolution test with gentle mechanistic stress for bioequivalence prediction of enteric-coated pellet formulations
This study aimed to develop a dissolution test that can predict the bioequivalence (BE) of enteric-coated pellet formulations. The original duloxetine hydrochloride capsule (reference formulation (RF); Cymbalta® 30 mg capsule) and four generic test formulations (two capsules (CP) and two orally disintegrating tablets (OD)) were used as model formulations. Clinical BE studies were conducted on 24-47 healthy male subjects under fasting conditions. Dissolution tests were performed using a compendial paddle method (PD) (paddle speed: 50 rpm) and a flow-through cell method (FTC) (flow rate: 4 mL/min). For a further test, cotto...
Source: European Journal of Pharmaceutical Sciences - October 26, 2023 Category: Drugs & Pharmacology Authors: Shotaro Ikuta Hidetoshi Nakagawa Toshiya Kai Kiyohiko Sugano Source Type: research
Bicarbonate buffer dissolution test with gentle mechanistic stress for bioequivalence prediction of enteric-coated pellet formulations
This study aimed to develop a dissolution test that can predict the bioequivalence (BE) of enteric-coated pellet formulations. The original duloxetine hydrochloride capsule (reference formulation (RF); Cymbalta® 30 mg capsule) and four generic test formulations (two capsules (CP) and two orally disintegrating tablets (OD)) were used as model formulations. Clinical BE studies were conducted on 24-47 healthy male subjects under fasting conditions. Dissolution tests were performed using a compendial paddle method (PD) (paddle speed: 50 rpm) and a flow-through cell method (FTC) (flow rate: 4 mL/min). For a further test, cotto...
Source: European Journal of Pharmaceutical Sciences - October 26, 2023 Category: Drugs & Pharmacology Authors: Shotaro Ikuta Hidetoshi Nakagawa Toshiya Kai Kiyohiko Sugano Source Type: research
