Concurrent Gabapentin and Opioid Use and Risk of Mortality in Medicare Recipients with Non-Cancer Pain
Clin Pharmacol Ther. 2023 Aug 7. doi: 10.1002/cpt.3019. Online ahead of print.ABSTRACTGabapentin is prescribed for pain and is perceived as safe generally. However, gabapentin can cause respiratory depression, exacerbated by concomitant central nervous system depressants (e.g., opioids), a concern for vulnerable populations. We compared mortality rates among new users of either gabapentin or duloxetine with or without concurrent opioids in the 20% Medicare sample. We conducted a new-user design retrospective cohort study, in Medicare enrollees ages 65-89 with non-cancer chronic pain and no severe illness who filled prescri...
Source: Cancer Control - August 7, 2023 Category: Cancer & Oncology Authors: Meghan A Corriere Laura L Daniel Alyson L Dickson Puran Nepal Kathi Hall W Dale Plummer William D Dupont Katherine T Murray C Michael Stein Wayne A Ray Cecilia P Chung Source Type: research
Concurrent Gabapentin and Opioid Use and Risk of Mortality in Medicare Recipients with Non-Cancer Pain
Clin Pharmacol Ther. 2023 Aug 7. doi: 10.1002/cpt.3019. Online ahead of print.ABSTRACTGabapentin is prescribed for pain and is perceived as safe generally. However, gabapentin can cause respiratory depression, exacerbated by concomitant central nervous system depressants (e.g., opioids), a concern for vulnerable populations. We compared mortality rates among new users of either gabapentin or duloxetine with or without concurrent opioids in the 20% Medicare sample. We conducted a new-user design retrospective cohort study, in Medicare enrollees ages 65-89 with non-cancer chronic pain and no severe illness who filled prescri...
Source: Clinical Pharmacology and Therapeutics - August 7, 2023 Category: Drugs & Pharmacology Authors: Meghan A Corriere Laura L Daniel Alyson L Dickson Puran Nepal Kathi Hall W Dale Plummer William D Dupont Katherine T Murray C Michael Stein Wayne A Ray Cecilia P Chung Source Type: research
A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough
Refractory cough, a chronic cough with an unclear diagnosis or poor treatment response. The symptoms are often stubborn and persistent, causing serious complications and lowering the patient's quality of life.... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 2, 2023 Category: Respiratory Medicine Authors: Shengyuan Wang, Shaohui Li, Heng Wu, Tongyangzi Zhang, Yixiao Chen, Yiqing Zhu, Siwan Wen, Cuiqin Shi, Li Yu and Xianghuai Xu Tags: Study Protocol Source Type: research
