Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies
This article provides recent updates related to the potential mechanisms, therapeutic strategies in treatment of OIPN, and pharmacokinetics of several methods of oxaliplatin administration in clinical trials. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 1, 2023 Category: Drugs & Pharmacology Source Type: research
Preclinical Investigation of Transdermal Route for Enhanced Bio-performance of Duloxetine HCl
AAPS PharmSciTech. 2023 Jul 19;24(6):154. doi: 10.1208/s12249-023-02607-7.ABSTRACTThe aim of the study was to develop and optimise drug-in-adhesive (DIA) transdermal patch of duloxetine HCl for enhanced drug delivery. DIA patch so developed reduced the dose and dosing frequency by enhancing bio-performance of the drug. A transdermal DIA patch having Duro-Tak 87-2287 as DIA polymer and Transcutol P as permeation enhancer loaded with 40% drug previously complexed with MeβCD duly characterised (FTIR, DSC, and SEM) was developed for in vivo study. Pharmacokinetic parameters of developed formulation were assessed and compared ...
Source: AAPS PharmSciTech - July 19, 2023 Category: Drugs & Pharmacology Authors: Rajiv Kumar V R Sinha Lalita Dahiya Amita Sarwal Source Type: research
Duloxetine for fibromyalgia syndrome: a systematic review and meta-analysis
The optimal dose of duloxetine in the management of fibromyalgia remains still controversial. Therefore, a systematic review and meta-analysis to investigate efficacy and safety of duloxetine was conducted. Th... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - July 17, 2023 Category: Orthopaedics Authors: Filippo Migliorini, Nicola Maffulli, J örg Eschweiler, Alice Baroncini, Andreas Bell and Giorgia Colarossi Tags: Systematic Review Source Type: research
Clinical efficacy of duloxetine in the treatment of axial symptoms after posterior cervical spine surgery: a retrospective study
To evaluate the efficacy of duloxetine in the treatment of patients with axial symptoms after posterior cervical spine surgery. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - July 12, 2023 Category: Orthopaedics Authors: Jinkai Liu, Xiaotian Yang, Wanli Jing, Xing Guo, Rui Wang, Jiaming Zhou and Yuan Xue Tags: Research article Source Type: research
A Patient with a History of Fibromyalgia Reports for an Intraoral Incisional Biopsy
A patient with a past medical history significant for fibromyalgia presents for an incisional oral biopsy. The condition is being managed pharmacologically with duloxetine and ibuprofen. Given the patient ’s medical condition and medications, specific considerations were placed on chair positioning, muscle pain and tenderness, and achieving hemostasis through local measures. The patient was advised to follow up in 2 weeks for postoperative evaluation. (Source: Dental Clinics of North America)
Source: Dental Clinics of North America - July 11, 2023 Category: Dentistry Authors: Roopali Kulkarni, Sunday Akintoye Source Type: research
A Brief Review on the Novel Therapies for Painful Diabetic Neuropathy
AbstractPurpose of ReviewAlmost half of people diagnosed with diabetes mellitus will develop painful diabetic neuropathy (PDN), a condition greatly impacting quality of life with complicated pathology. While there are different FDA approved forms of treatment, many of the existing options are difficult to manage with comorbities and are associated with unwanted side effects. Here, we summarize the current and novel treatments for PDN.Recent FindingsCurrent research is exploring alternative pain management treatments from the first line options of pregabalin, gabapentin, duloxetine, and amitriptyline which often have side e...
Source: Current Pain and Headache Reports - July 1, 2023 Category: Neurology Source Type: research
Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled study
CONCLUSIONS: This is the first randomised controlled study demonstrating the effectiveness of the adding on therapy of PEA+ALC to DLX+PGB in FM patients.PMID:37378482 | DOI:10.55563/clinexprheumatol/pmdzcq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 28, 2023 Category: Rheumatology Authors: Fausto Salaffi Sonia Farah Piercarlo Sarzi-Puttini Marco Di Carlo Source Type: research
Pharmacologic Management of Cancer-Related Pain in Pregnant Patients
The objective of this review is to provide clinicians with an understanding of pain experienced by pregnant patients with cancer and medications that may be used to help manage cancer-related pain. Nociceptive pain results from damage to somatic or visceral tissues that may be directly caused by cancer. This type of pain can be managed in pregnant patients using acetaminophen and/or nonsteroidal antiinflammatory drugs as first-line agents. In nociceptive pain not managed by non-opioid analgesics, buprenorphine is recommended for those requiring chronic opioids to help manage their pain. Neuropathic pain that results from d...
Source: Drugs - June 22, 2023 Category: Drugs & Pharmacology Source Type: research
Baseline depressive symptoms as predictors of efficacy and tolerability of the treatment with duloxetine: a network analysis approach
In this study, we aimed to explore the baseline characteristics of depressive symptoms associated with a good response to duloxetine treatment using a network analysis. Additionally, the relationship between baseline psychopathological symptoms and treatment tolerability was assessed.MethodsThe sample of 88 drug–free patients with active depressive episode, who started monotherapy with increasing doses of duloxetine were evaluated. The Hamilton Depression Rating Scale (HAM-D) was used to assess depression severity and the UKU side effect rating scale to monitor adverse drug reactions (ADRs). A network analysis that explo...
Source: Frontiers in Psychiatry - June 16, 2023 Category: Psychiatry Source Type: research
Effect of duloxetine on pain and opioid consumption after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized controlled trials
Conclusion Perioperative duloxetine significantly decreased postoperative pain and opioid consumption with good safety profiles. Further high quality designed and well-controlled randomized trials are warranted. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - June 9, 2023 Category: Drugs & Pharmacology Source Type: research
The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review
Conclusion: Duloxetine may be an effective treatment option for postoperative pain following TKA, but further rigorously designed and well-controlled randomized trials are required.PMID:37279647 | DOI:10.1177/10225536231177482 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - June 6, 2023 Category: Orthopaedics Authors: Emad Kouhestani Reza Minaei Amir Salimi Yoosef Mehrabi Shakila Meshkat Source Type: research
The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review
Conclusion: Duloxetine may be an effective treatment option for postoperative pain following TKA, but further rigorously designed and well-controlled randomized trials are required.PMID:37279647 | DOI:10.1177/10225536231177482 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - June 6, 2023 Category: Orthopaedics Authors: Emad Kouhestani Reza Minaei Amir Salimi Yoosef Mehrabi Shakila Meshkat Source Type: research
