Antidepressant duloxetine hydrochloride protects against ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation

CONCLUSION: The findings from this study suggest that DH, instead of causing bone mass loss, may assist in alleviating postmenopausal osteoporosis. These results can serve as a reference for the clinical treatment of patients with perimenopausal or postmenopausal depression using antidepressants.PMID:37913736 | DOI:10.1016/j.biopha.2023.115810

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 1, 2023 Category: Drugs & Pharmacology Authors: Weijun Zhou Wenyun Zhou Yonghao Bi Zibin Zhou Zhigao Zhou Shaozhe Chen Gang Xie Zhen Lian Guixin Yuan Guanfeng Yao Source Type: research