Duloxetine as an Analgesic in Patients Who Do Not Have Central Sensitivity Undergoing Single-Sitting, Bilateral Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized, Placebo-Controlled Trial

Pain control and patient satisfaction after total knee arthroplasty (TKA) have room for improvement. While studies have reported better analgesic outcomes with antidepressants like duloxetine in patients who do not have central sensitivity, we undertook this trial to determine the short and midterm analgesic role of low-dose duloxetine in patients who do not have central sensitivity.

Source: The Journal of Arthroplasty - February 12, 2024 Category: Orthopaedics Authors: Amyn M. Rajani, Anmol RS. Mittal, Vishal U. Kulkarni, Megha Desai, Rishab Dubey, Khushi Rajani, Kashish Rajani Source Type: research