PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome
BackgroundWe performed a transcriptomic analysis of adrenal signaling pathways in various forms of endogenous Cushing’s syndrome (CS) to define areas of dysregulated and druggable targets.MethodologyNext-generation sequencing was performed on adrenal samples of patients with primary bilateral macronodular adrenal hyperplasia (PBMAH, n=10) and control adrenal samples (n=8). The validation groups included cortisol-producing adenoma (CPA, n=9) and samples from patients undergoing bilateral adrenalectomy for Cushing’s disease (BADX-CD, n=8). In vivo findings were further characterized using three adrenocortical cell-lines ...
Source: Frontiers in Endocrinology - November 30, 2023 Category: Endocrinology Source Type: research
Bilateral co-secretory lesions presenting with coexisting Cushing syndrome and primary aldosteronism: a case report
There is an increasing number of cases of aldosterone- and cortisol-producing adenomas (A/CPAs) reported in the context of primary aldosteronism (PA). Most of these patients have PA complicated with subclinica... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - November 29, 2023 Category: Endocrinology Authors: Hongjiao Gao, Li Li, Fei Chen, Yan Ren, Tao Chen and Haoming Tian Tags: Case report Source Type: research
Alternative approach to BIPSS in the differential diagnosis of ACTH-dependent Cushing's syndrome
J Clin Endocrinol Metab. 2023 Nov 23:dgad676. doi: 10.1210/clinem/dgad676. Online ahead of print.NO ABSTRACTPMID:37995302 | DOI:10.1210/clinem/dgad676 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 23, 2023 Category: Endocrinology Authors: M ônica Gadelha Luiz Eduardo Wildemberg Source Type: research
The utility of IGF1 in the evaluation of pediatric patients with endogenous hypercortisolemia
CONCLUSIONS: IGF-1 levels in CS are on the lower side of the normal range during active disease and remain low at one year after treatment. IGF-1 levels correlated mainly with markers of hypercortisolemia rather than the short stature of patients and should not be used in the assessment of growth in this population.IMPACT: We report that IGF-1 levels in childhood during active hypercortisolemia and up to 1 year after resolution are on the lower side of the normal range. Our results demonstrate that IGF-1 levels during active hypercortisolemia correlate mainly with markers of Cushing syndrome. This report adds data to the c...
Source: Pediatric Research - November 22, 2023 Category: Pediatrics Authors: Jessica R Weinberg Mariana Voudouri Meg Keil Constantine A Stratakis Christina Tatsi Source Type: research
The utility of IGF1 in the evaluation of pediatric patients with endogenous hypercortisolemia
CONCLUSIONS: IGF-1 levels in CS are on the lower side of the normal range during active disease and remain low at one year after treatment. IGF-1 levels correlated mainly with markers of hypercortisolemia rather than the short stature of patients and should not be used in the assessment of growth in this population.IMPACT: We report that IGF-1 levels in childhood during active hypercortisolemia and up to 1 year after resolution are on the lower side of the normal range. Our results demonstrate that IGF-1 levels during active hypercortisolemia correlate mainly with markers of Cushing syndrome. This report adds data to the c...
Source: Pediatric Research - November 22, 2023 Category: Pediatrics Authors: Jessica R Weinberg Mariana Voudouri Meg Keil Constantine A Stratakis Christina Tatsi Source Type: research
The utility of IGF1 in the evaluation of pediatric patients with endogenous hypercortisolemia
CONCLUSIONS: IGF-1 levels in CS are on the lower side of the normal range during active disease and remain low at one year after treatment. IGF-1 levels correlated mainly with markers of hypercortisolemia rather than the short stature of patients and should not be used in the assessment of growth in this population.IMPACT: We report that IGF-1 levels in childhood during active hypercortisolemia and up to 1 year after resolution are on the lower side of the normal range. Our results demonstrate that IGF-1 levels during active hypercortisolemia correlate mainly with markers of Cushing syndrome. This report adds data to the c...
Source: Pediatric Research - November 22, 2023 Category: Pediatrics Authors: Jessica R Weinberg Mariana Voudouri Meg Keil Constantine A Stratakis Christina Tatsi Source Type: research
Pharmacogenetics of pediatric acute lymphoblastic leukemia in Uruguay: adverse events related to induction phase drugs
This study aims to identify genetic variants related to drugs administered during the induction phase and analyze their contribution to adverse effects, considering individual genetic ancestry. Ten polymorphisms in five genes (ABCB1, CYP3A5, CEP72, ASNS, and GRIA1) related to prednisone, vincristine, and L-asparaginase were genotyped in 200 patients. Ancestry was determined using 45 ancestry informative markers (AIMs). The sample ancestry was 69.2% European, 20.1% Native American, and 10.7% African, but with high heterogeneity. Mucositis, Cushing syndrome, and neurotoxicity were the only adverse effects linked with genetic...
Source: Frontiers in Pharmacology - November 17, 2023 Category: Drugs & Pharmacology Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess - a retrospective single centre study
CONCLUSIONS: NLR, SII and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
Inflammation-based scores in benign adrenocortical tumours are linked to the degree of cortisol excess: a retrospective single-centre study
CONCLUSIONS: Neutrophil-to-lymphocyte ratio, SII, and LMR correlated with the degree of cortisol excess in benign adrenocortical tumours and were altered in patients with CS and MACS. These findings suggest that, similar to clinically overt CS, MACS also affects the immune function, potentially contributing to the MACS-associated comorbidities.PMID:37962923 | DOI:10.1093/ejendo/lvad151 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 14, 2023 Category: Endocrinology Authors: Vittoria Favero Alessandro Prete Alessandra Mangone Yasir S Elhassan Valentina Pucino Miriam Asia Rowan Hardy Iacopo Chiodini Cristina L Ronchi Source Type: research
