Prolonged adrenal insufficiency following discontinuation of Osilodrostat treatment for intense hypercortisolism
We report two additional cases of persistent prolonged adrenal insufficiency after discontinuation of osilodrostat treatment for intense hypercortisolism due to Cushing's disease and ectopic ACTH syndrome. In addition, we show for that adrenal insufficiency in these patients was associated with low/normal 11-deoxycortisol concentrations despite high plasma ACTH concentrations. These results suggest that CYP11B1 is not the only target of osilodrostat and that, in vivo, osilodrostat has other prolonged and strong inhibitory effect on adrenal steroidogenesis upstream of CYP11B1. Knowledge of this remnant effect is important f...
Source: European Journal of Endocrinology - December 20, 2023 Category: Endocrinology Authors: A Ferriere S Salenave M Puerto J Young A Tabarin Source Type: research
Long non-coding RNA expression in PBMCs of patients with active pulmonary tuberculosis
ConclusionThe abnormally expressed lncRNAs identified in this research may provide crucial information for understanding the pathophysiological characteristics of TB patients and the dysfunction of PBMCs. Our findings reveal potential targets for early TB diagnosis and therapy, as well as offer new insights into the mechanisms underlying TB infection. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - December 14, 2023 Category: Microbiology Source Type: research
Atypical Presentation and Course of ACTH-independent Cushing's Syndrome in Two Families
We report three cases suffering from CNC with unique features in diagnosis and follow-up. All cases had obesity and a cushingoid appearance and exhibited laboratory characteristics of hypercortisolism. However biochemical and radiological examinations initially suggested Cushing's disease in one case . All of the cases were treated surgically; two of them underwent bilateral adrenalectomy at once, one of them had unilateral adrenalectomy at first but required contralateral adrenalectomy after nine months. Contrary to what is usually known regarding PPNAD, the adrenal glands of two cases (case 2 and 3) had a macronodular mo...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - December 12, 2023 Category: Endocrinology Authors: K übra Yüksek Acinikli Sezer Acar Ahu Paket çi Özgür Kırbıyık Mert Erba ş Özge Besci G özde Akın Kağızmanlı Deniz K ızmazoğlu Oktay Ulusoy Erdener Özer Kutsal Y örükoğlu Ayhan Abac ı Handan G üleryüz Ece B öber Korcan Demir Source Type: research
E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess
CONCLUSION: E47 is a GC-dependent gene that is upregulated in GC excess potentially aiming at reducing metabolic glucocorticoid side effects such as dyslipidemia.PMID:38047107 | PMC:PMC10691538 | DOI:10.3389/fendo.2023.1249863 (Source: Cancer Control)
Source: Cancer Control - December 4, 2023 Category: Cancer & Oncology Authors: Wei Zhang Hanna Nowotny Marily Theodoropoulou Julia Simon Charlotte M Hemmer Martin Bidlingmaier Matthias K Auer Martin Reincke Henriette Uhlenhaut Nicole Reisch Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2023 Category: Cardiology Authors: Poredos P Schernthaner Gh Blinc A Mikhailidis Dp Jensterle M Anagnostis P Antignani Pl Bajuk Studen K Šabović M Je žovnik Mk Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Poredos P Schernthaner Gh Blinc A Mikhailidis Dp Jensterle M Anagnostis P Antignani Pl Bajuk Studen K Šabović M Je žovnik Mk Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Atherosclerosis)
Source: Atherosclerosis - December 1, 2023 Category: Cardiology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
Endocrine Disorders and Peripheral Arterial Disease - A Series of Reviews Cushing Syndrome-Cortisol Excess
In conclusion, CS promotes atherosclerosis, including peripheral artery disease, by causing functional and morphological deterioration of the arterial vessel wall and increasing the presence of classical risk factors of atherosclerosis.PMID:38038006 | DOI:10.2174/0115701611272145231106053914 (Source: Current Vascular Pharmacology)
Source: Current Vascular Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: P Poredos G H Schernthaner A Blinc D P Mikhailidis M Jensterle P Anagnostis P L Antignani K Bajuk Studen M Šabović M K Je žovnik Source Type: research
