KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
DISCUSSION: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
DISCUSSION: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
The endocrine phenotype induced by paediatric adrenocortical tumours is age- and sex-dependent
CONCLUSIONS: The endocrine phenotype induced by paediatric ACT is age- and sex-dependent.PMID:38318871 | DOI:10.1210/clinem/dgae073 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 6, 2024 Category: Endocrinology Authors: Marina Kunstreich Desiree Dunstheimer Pascal Mier Paul-Martin Holterhus Stefan A Wudy Angela H übner Antje Redlich Michaela Kuhlen Source Type: research
Utilizing dehydroepiandrosterone sulfate and its ratio for detecting mild autonomous cortisol excess in patients with adrenal incidentaloma
J Med Life. 2023 Oct;16(10):1456-1461. doi: 10.25122/jml-2023-0092.ABSTRACTSubclinical Cushing syndrome is a condition of mild autonomous cortisol excess (MACE) that lacks typical features of Cushing syndrome but is associated with many complications. It represents a common hormonal dysfunction among patients with adrenal incidentaloma (AI), defined as unexpected masses or lesions found in the adrenal glands during radiological examinations of the chest or abdomen unrelated to adrenal gland assessment. The study evaluated the accuracy of dehydroepiandrosterone sulfate (DHEA-S) and dehydroepiandrosterone sulfate ratio (calc...
Source: Journal of Medicine and Life - February 5, 2024 Category: General Medicine Authors: Dheyaa Al-Waeli Haider Alidrisi Abbas Mansour Source Type: research
