Epigenetic Mechanisms Modulated by Glucocorticoids with a Focus on Cushing's Syndrome
J Clin Endocrinol Metab. 2024 Mar 22:dgae151. doi: 10.1210/clinem/dgae151. Online ahead of print.ABSTRACTIn Cushing's syndrome (CS), prolonged exposure to high cortisol levels results in a wide range of devastating effects causing multisystem morbidity. Despite the efficacy of treatment leading to disease remission and clinical improvement, hypercortisolism-induced complications may persist. Since glucocorticoids use the epigenetic machinery as a mechanism of action to modulate gene expression, the persistence of some comorbidities may be mediated by hypercortisolism-induced long-lasting epigenetic changes. Additionally, g...
Source: The Journal of Clinical Endocrinology and Metabolism - March 22, 2024 Category: Endocrinology Authors: Ticiana Paes Richard A Feelders Leo J Hofland Source Type: research
Epigenetic Mechanisms Modulated by Glucocorticoids with a Focus on Cushing's Syndrome
J Clin Endocrinol Metab. 2024 Mar 22:dgae151. doi: 10.1210/clinem/dgae151. Online ahead of print.ABSTRACTIn Cushing's syndrome (CS), prolonged exposure to high cortisol levels results in a wide range of devastating effects causing multisystem morbidity. Despite the efficacy of treatment leading to disease remission and clinical improvement, hypercortisolism-induced complications may persist. Since glucocorticoids use the epigenetic machinery as a mechanism of action to modulate gene expression, the persistence of some comorbidities may be mediated by hypercortisolism-induced long-lasting epigenetic changes. Additionally, g...
Source: The Journal of Clinical Endocrinology and Metabolism - March 22, 2024 Category: Endocrinology Authors: Ticiana Paes Richard A Feelders Leo J Hofland Source Type: research
Machine Learning May Be An Alternative To BIPSS In The Differential Diagnosis Of ACTH-Dependent Cushing's Syndrome
CONCLUSION: ML algorithms have the potential to serve as an alternative decision support tool to invasive procedures in the differential diagnosis of ACTH-dependent CS.PMID:38501466 | DOI:10.1210/clinem/dgae180 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 19, 2024 Category: Endocrinology Authors: Ahmet Numan Demir Deger Ayata Ahmet Oz Cem Sulu Zehra Kara Serdar Sahin Dilan Ozaydin Bora Korkmazer Serdar Arslan Osman Kizilkilic Sema Ciftci Ozlem Celik Hande Mefkure Ozkaya Necmettin Tanriover Nurperi Gazioglu Pinar Kadioglu Source Type: research
A challenging case of ectopic ACTH-dependent Cushing's syndrome due to medullary thyroid carcinoma
Endokrynol Pol. 2024;75(1):115-116. doi: 10.5603/ep.96863.ABSTRACTNot required for Clinical Vignette.PMID:38497400 | DOI:10.5603/ep.96863 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Maria Komisarz-Calik Paulina Sarba Ma łgorzata Trofimiuk-Müldner Grzegorz Soko łowski Joanna Szpor Alicja Hubalewska-Dydejczyk Source Type: research
Prevalence of endocrine disorders in 304 premenopausal women referred with oligomenorrhoea
CONCLUSIONS: We found higher prevalence of CS in patients with oligomenorrhoea even in the absence of clinical signs. Therefore, we suggest routine screening for CS during the evaluation of patients with oligomenorrhoea and/or PCOS. The likelihood of CS is greater in patients with high androgen, especially DHEA-S levels.PMID:38497394 | DOI:10.5603/ep.96737 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Hamiyet Yilmaz Mustafa Demirpence Umit Belet Ibrahim Ozkili ç Ayfer Colak Savas Ceylan Muammer Sar ıkaya Erdem Yasar Source Type: research
A challenging case of ectopic ACTH-dependent Cushing's syndrome due to medullary thyroid carcinoma
Endokrynol Pol. 2024;75(1):115-116. doi: 10.5603/ep.96863.ABSTRACTNot required for Clinical Vignette.PMID:38497400 | DOI:10.5603/ep.96863 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Maria Komisarz-Calik Paulina Sarba Ma łgorzata Trofimiuk-Müldner Grzegorz Soko łowski Joanna Szpor Alicja Hubalewska-Dydejczyk Source Type: research
Prevalence of endocrine disorders in 304 premenopausal women referred with oligomenorrhoea
CONCLUSIONS: We found higher prevalence of CS in patients with oligomenorrhoea even in the absence of clinical signs. Therefore, we suggest routine screening for CS during the evaluation of patients with oligomenorrhoea and/or PCOS. The likelihood of CS is greater in patients with high androgen, especially DHEA-S levels.PMID:38497394 | DOI:10.5603/ep.96737 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Hamiyet Yilmaz Mustafa Demirpence Umit Belet Ibrahim Ozkili ç Ayfer Colak Savas Ceylan Muammer Sar ıkaya Erdem Yasar Source Type: research
A challenging case of ectopic ACTH-dependent Cushing's syndrome due to medullary thyroid carcinoma
Endokrynol Pol. 2024;75(1):115-116. doi: 10.5603/ep.96863.ABSTRACTNot required for Clinical Vignette.PMID:38497400 | DOI:10.5603/ep.96863 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Maria Komisarz-Calik Paulina Sarba Ma łgorzata Trofimiuk-Müldner Grzegorz Soko łowski Joanna Szpor Alicja Hubalewska-Dydejczyk Source Type: research
Prevalence of endocrine disorders in 304 premenopausal women referred with oligomenorrhoea
CONCLUSIONS: We found higher prevalence of CS in patients with oligomenorrhoea even in the absence of clinical signs. Therefore, we suggest routine screening for CS during the evaluation of patients with oligomenorrhoea and/or PCOS. The likelihood of CS is greater in patients with high androgen, especially DHEA-S levels.PMID:38497394 | DOI:10.5603/ep.96737 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Hamiyet Yilmaz Mustafa Demirpence Umit Belet Ibrahim Ozkili ç Ayfer Colak Savas Ceylan Muammer Sar ıkaya Erdem Yasar Source Type: research
A challenging case of ectopic ACTH-dependent Cushing's syndrome due to medullary thyroid carcinoma
Endokrynol Pol. 2024;75(1):115-116. doi: 10.5603/ep.96863.ABSTRACTNot required for Clinical Vignette.PMID:38497400 | DOI:10.5603/ep.96863 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Maria Komisarz-Calik Paulina Sarba Ma łgorzata Trofimiuk-Müldner Grzegorz Soko łowski Joanna Szpor Alicja Hubalewska-Dydejczyk Source Type: research
Prevalence of endocrine disorders in 304 premenopausal women referred with oligomenorrhoea
CONCLUSIONS: We found higher prevalence of CS in patients with oligomenorrhoea even in the absence of clinical signs. Therefore, we suggest routine screening for CS during the evaluation of patients with oligomenorrhoea and/or PCOS. The likelihood of CS is greater in patients with high androgen, especially DHEA-S levels.PMID:38497394 | DOI:10.5603/ep.96737 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Hamiyet Yilmaz Mustafa Demirpence Umit Belet Ibrahim Ozkili ç Ayfer Colak Savas Ceylan Muammer Sar ıkaya Erdem Yasar Source Type: research
A challenging case of ectopic ACTH-dependent Cushing's syndrome due to medullary thyroid carcinoma
Endokrynol Pol. 2024;75(1):115-116. doi: 10.5603/ep.96863.ABSTRACTNot required for Clinical Vignette.PMID:38497400 | DOI:10.5603/ep.96863 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Maria Komisarz-Calik Paulina Sarba Ma łgorzata Trofimiuk-Müldner Grzegorz Soko łowski Joanna Szpor Alicja Hubalewska-Dydejczyk Source Type: research
Prevalence of endocrine disorders in 304 premenopausal women referred with oligomenorrhoea
CONCLUSIONS: We found higher prevalence of CS in patients with oligomenorrhoea even in the absence of clinical signs. Therefore, we suggest routine screening for CS during the evaluation of patients with oligomenorrhoea and/or PCOS. The likelihood of CS is greater in patients with high androgen, especially DHEA-S levels.PMID:38497394 | DOI:10.5603/ep.96737 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 18, 2024 Category: Endocrinology Authors: Hamiyet Yilmaz Mustafa Demirpence Umit Belet Ibrahim Ozkili ç Ayfer Colak Savas Ceylan Muammer Sar ıkaya Erdem Yasar Source Type: research
