A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Trends in Endocrinology and Metabolism: TEM - December 24, 2023 Category: Endocrinology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
Prolonged adrenal insufficiency following discontinuation of Osilodrostat treatment for intense hypercortisolism
We report two additional cases of persistent prolonged adrenal insufficiency after discontinuation of osilodrostat treatment for intense hypercortisolism due to Cushing's disease and ectopic ACTH syndrome. In addition, we show for that adrenal insufficiency in these patients was associated with low/normal 11-deoxycortisol concentrations despite high plasma ACTH concentrations. These results suggest that CYP11B1 is not the only target of osilodrostat and that, in vivo, osilodrostat has other prolonged and strong inhibitory effect on adrenal steroidogenesis upstream of CYP11B1. Knowledge of this remnant effect is important f...
Source: European Journal of Endocrinology - December 20, 2023 Category: Endocrinology Authors: A Ferriere S Salenave M Puerto J Young A Tabarin Source Type: research
