Cushing's Syndrome is associated with Gut Microbial Dysbiosis and Cortisol-Degrading Bacteria
CONCLUSIONS: This study provides evidence of gut microbial dysbiosis in patients with CS and identifies a group of CS-enriched bacteria capable of degrading cortisol. These findings highlight the potential role of gut microbiota in regulating host steroid hormone levels, and consequently host health.PMID:38157274 | DOI:10.1210/clinem/dgad766 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - December 29, 2023 Category: Endocrinology Authors: Minchun Zhang Zhun Shi Chao Wu Fangming Yang Tingwei Su Xiaohuan Jing Juan Shi Huahui Ren Lei Jiang Yiran Jiang Cui Zhang Wenzhong Zhou Yijing Zhou Kui Wu Sichang Zheng Xu Zhong Luming Wu Weiqiong Gu Jie Hong Jiqiu Wang Guang Ning Ruixin Liu Huanzi Zhong Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS.Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention which is widely adopted appears to be necessary in patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Krsek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sala Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have an elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS. Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention that is widely adopted appears to be necessary for patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Kr šek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sa Source Type: research
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
CONCLUSION: Patients with CS have an elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS. Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention that is widely adopted appears to be necessary for patients with CS.PMID:38146835 | DOI:10.1093/ejendo/lvad176 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - December 26, 2023 Category: Endocrinology Authors: Kristina Isand Richard Feelders Thierry Brue Miklos Toth Timo Deutschbein Martin Reincke Michal Kr šek Alicia Santos Frank Demtr öder Olivier Chabre Christian J Strasburger Anna Aulinas Maso Vallo Volke Alberto M Pereira R üdiger Lohmann Ignasi Gich Sa Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
A clinical perspective on ectopic Cushing's syndrome
Trends Endocrinol Metab. 2023 Dec 23:S1043-2760(23)00248-5. doi: 10.1016/j.tem.2023.12.003. Online ahead of print.ABSTRACTCushing's syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10-20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequentl...
Source: Cancer Control - December 24, 2023 Category: Cancer & Oncology Authors: Oskar Ragnarsson C Christofer Juhlin David J Torpy Henrik Falhammar Source Type: research
