KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas

CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013

Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research