Antibacterial and Antioxidant Efficacies of Secondary Metabolites from the Roots of < em > Cyphostemma adenocaule < /em > : A Combined < em > In Vitro < /em > and < em > In Silico < /em > Study
J Trop Med. 2024 Mar 6;2024:1679695. doi: 10.1155/2024/1679695. eCollection 2024.ABSTRACTCyphostemma adenocaule is a therapeutic plant traditionally used to treat rabies, snake bite, diarrhea, and wound healing. To address the bioactive compounds exhibiting these activities, we performed a comprehensive study on the roots of the plant. Thus, the present study aims to inspect the in vitro antioxidant and antibacterial efficacies of compounds isolated from the combined dichloromethane : methanol (1 : 1) and methanol extracts of C. adenocaule along with the in silico study of their interaction with selected protein targets. T...
Source: Molecular Medicine - March 14, 2024 Category: Molecular Biology Authors: Hadush Gebrehiwot Yadessa Melaku Muhdin Aliye Urgessa Ensermu Aman Dekebo Milkyas Endale Daniel Rentsch Mo Hunsen Source Type: research
Fluorescent responsive membrane based on terbium coordination polymer and carbon dots with AIE effect for rapid and visual detection of fluoroquinolone
In this study, based on aggregation-induced emission (AIE) effect and antenna effect, a novel portable fluorescent responsive membrane was constructed with red carbon dots (R-CDs) as reference signal and terbium coordination polymer (Tb-AMP CPs) as response signal for visual, instrument-free, and sensitive detection of fluoroquinolones (FQs). Specifically, the fluorescent responsive membrane (R-T membrane) was prepared by physically depositing R-CDs with AIE property and Tb-AMP CPs on the surface of polyvinylidene fluoride filter membranes at ambient temperature. In the presence of FQs, Tb3+ in the Tb-AMP CPs of the prepar...
Source: Biosensors and Bioelectronics - March 14, 2024 Category: Biotechnology Authors: Yunyun Hu Xi Chen Kai Wang Chuang Jiang Wenya Liu Siyu Zhang Mingming Zheng Yibin Zhou Yaqing Xiao Yingnan Liu Source Type: research
Antibacterial and Antioxidant Efficacies of Secondary Metabolites from the Roots of < em > Cyphostemma adenocaule < /em > : A Combined < em > In Vitro < /em > and < em > In Silico < /em > Study
J Trop Med. 2024 Mar 6;2024:1679695. doi: 10.1155/2024/1679695. eCollection 2024.ABSTRACTCyphostemma adenocaule is a therapeutic plant traditionally used to treat rabies, snake bite, diarrhea, and wound healing. To address the bioactive compounds exhibiting these activities, we performed a comprehensive study on the roots of the plant. Thus, the present study aims to inspect the in vitro antioxidant and antibacterial efficacies of compounds isolated from the combined dichloromethane : methanol (1 : 1) and methanol extracts of C. adenocaule along with the in silico study of their interaction with selected protein targets. T...
Source: Journal of Tropical Medicine - March 14, 2024 Category: Tropical Medicine Authors: Hadush Gebrehiwot Yadessa Melaku Muhdin Aliye Urgessa Ensermu Aman Dekebo Milkyas Endale Daniel Rentsch Mo Hunsen Source Type: research
On-site extraction using a 3D printed device coated with Zn/Co-ZIF-derived carbon followed by an on-line SIA-HPLC-FL system for fluoroquinolones determination in wastewater
Talanta. 2024 Mar 11;273:125897. doi: 10.1016/j.talanta.2024.125897. Online ahead of print.ABSTRACTA 3D printed device covered with Zn/Co-ZIF-derived carbon allows the on-site extraction of fluoroquinolones (FQs) from wastewater, avoiding the sample transportation to the laboratory, and the subsequent elution, separation and determination using an on-line flow system based on sequential injection analysis (SIA) coupled to HPLC-FL. Several parameters that affect the extraction efficiency and desorption were optimized including the sorption phase immobilization technique on the 3D device, extraction time, pH effect, sample v...
Source: Talanta - March 14, 2024 Category: Chemistry Authors: D Barzallo A Est án N Cresp í C Palomino G Turnes E Palacio L Ferrer Source Type: research
Fluorescent responsive membrane based on terbium coordination polymer and carbon dots with AIE effect for rapid and visual detection of fluoroquinolone
In this study, based on aggregation-induced emission (AIE) effect and antenna effect, a novel portable fluorescent responsive membrane was constructed with red carbon dots (R-CDs) as reference signal and terbium coordination polymer (Tb-AMP CPs) as response signal for visual, instrument-free, and sensitive detection of fluoroquinolones (FQs). Specifically, the fluorescent responsive membrane (R-T membrane) was prepared by physically depositing R-CDs with AIE property and Tb-AMP CPs on the surface of polyvinylidene fluoride filter membranes at ambient temperature. In the presence of FQs, Tb3+ in the Tb-AMP CPs of the prepar...
Source: Biosensors and Bioelectronics - March 14, 2024 Category: Biotechnology Authors: Yunyun Hu Xi Chen Kai Wang Chuang Jiang Wenya Liu Siyu Zhang Mingming Zheng Yibin Zhou Yaqing Xiao Yingnan Liu Source Type: research
Antibacterial and Antioxidant Efficacies of Secondary Metabolites from the Roots of < em > Cyphostemma adenocaule < /em > : A Combined < em > In Vitro < /em > and < em > In Silico < /em > Study
J Trop Med. 2024 Mar 6;2024:1679695. doi: 10.1155/2024/1679695. eCollection 2024.ABSTRACTCyphostemma adenocaule is a therapeutic plant traditionally used to treat rabies, snake bite, diarrhea, and wound healing. To address the bioactive compounds exhibiting these activities, we performed a comprehensive study on the roots of the plant. Thus, the present study aims to inspect the in vitro antioxidant and antibacterial efficacies of compounds isolated from the combined dichloromethane : methanol (1 : 1) and methanol extracts of C. adenocaule along with the in silico study of their interaction with selected protein targets. T...
Source: Journal of Tropical Medicine - March 14, 2024 Category: Tropical Medicine Authors: Hadush Gebrehiwot Yadessa Melaku Muhdin Aliye Urgessa Ensermu Aman Dekebo Milkyas Endale Daniel Rentsch Mo Hunsen Source Type: research
Enhancing bactericidal activities of ciprofloxacin by targeting the trans-translation system that is involved in stress responses in Klebsiella pneumoniae
Arch Microbiol. 2024 Mar 13;206(4):154. doi: 10.1007/s00203-024-03872-1.ABSTRACTAlthough the trans-translation system is a promising target for antcibiotic development, its antibacterial mechanism in Klebsiella pneumoniae (KP) is unclear. Considering that tmRNA was the core component of trans-translation, this study firstly investigated phenotypic changes caused by various environmental stresses in KP lacking trans-translation activities (tmRNA-deleted), and then aimed to evaluate antibacterial activities of the trans-translation-targeting antibiotic combination (tobramycin/ciprofloxacin) in clinical KP isolates based on i...
Source: Archives of Microbiology - March 13, 2024 Category: Microbiology Authors: Wendong Fang Jie Xu Zilan Wei Jiahui Wu Weihui Wu Youliang Wang Shuiping Chen Source Type: research
Human Campylobacter spp. infections in Italy
ConclusionCampylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 12, 2024 Category: Microbiology Source Type: research
Design, semi-synthesis of soft coral-derived < em > Aspergillus < /em > sp. secondary metabolite geodin derivatives and their antibacterial activities
Nat Prod Res. 2024 Mar 10:1-9. doi: 10.1080/14786419.2024.2326990. Online ahead of print.ABSTRACTA series of novel ester derivatives 2 - 7, of natural product geodin 1, isolated from the soft coral-derived fungus Aspergillus sp., were designed and semi-synthesised through one step reaction with high yield. Compound 5 showed strong antifouling inhibitory activities with MIC of 4.80 μM while compound 4 showed selective inhibitory activities with MICs values 8.59 μM against Aeromonas salmonicida and Pseudomonas aeruginosa (Sea-Nine 211, MIC = 0.27 μM). Compounds 3, 4 and 6 showed potent anti-pathogenic inhibitory activitie...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Gulab Said Amjad Ali Latif Ahmad Source Type: research
Microbiology of infection-related complications after transrectal ultrasound-guided prostate biopsy
CONCLUSIONS: We observed a low rate of infection-related complications and antibiotic-related adverse events in the setting of antibiotic prophylaxis with ciprofloxacin and cephalexin for 24 hours, without pre-procedure rectal culture screening. Investigation into procedural or host factors may uncover opportunities to further reduce infection-related complications.PMID:38466864 | DOI:10.5489/cuaj.8553 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - March 11, 2024 Category: Urology & Nephrology Authors: Cynthia T Nguyen Alison Lew Natasha N Pettit Jennifer Pisano Luke F Reynolds Source Type: research
Design, semi-synthesis of soft coral-derived < em > Aspergillus < /em > sp. secondary metabolite geodin derivatives and their antibacterial activities
Nat Prod Res. 2024 Mar 10:1-9. doi: 10.1080/14786419.2024.2326990. Online ahead of print.ABSTRACTA series of novel ester derivatives 2 - 7, of natural product geodin 1, isolated from the soft coral-derived fungus Aspergillus sp., were designed and semi-synthesised through one step reaction with high yield. Compound 5 showed strong antifouling inhibitory activities with MIC of 4.80 μM while compound 4 showed selective inhibitory activities with MICs values 8.59 μM against Aeromonas salmonicida and Pseudomonas aeruginosa (Sea-Nine 211, MIC = 0.27 μM). Compounds 3, 4 and 6 showed potent anti-pathogenic inhibitory activitie...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Gulab Said Amjad Ali Latif Ahmad Source Type: research
Microbiology of infection-related complications after transrectal ultrasound-guided prostate biopsy
CONCLUSIONS: We observed a low rate of infection-related complications and antibiotic-related adverse events in the setting of antibiotic prophylaxis with ciprofloxacin and cephalexin for 24 hours, without pre-procedure rectal culture screening. Investigation into procedural or host factors may uncover opportunities to further reduce infection-related complications.PMID:38466864 | DOI:10.5489/cuaj.8553 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - March 11, 2024 Category: Urology & Nephrology Authors: Cynthia T Nguyen Alison Lew Natasha N Pettit Jennifer Pisano Luke F Reynolds Source Type: research
Microbiology of infection-related complications after transrectal ultrasound-guided prostate biopsy
CONCLUSIONS: We observed a low rate of infection-related complications and antibiotic-related adverse events in the setting of antibiotic prophylaxis with ciprofloxacin and cephalexin for 24 hours, without pre-procedure rectal culture screening. Investigation into procedural or host factors may uncover opportunities to further reduce infection-related complications.PMID:38466864 | DOI:10.5489/cuaj.8553 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - March 11, 2024 Category: Urology & Nephrology Authors: Cynthia T Nguyen Alison Lew Natasha N Pettit Jennifer Pisano Luke F Reynolds Source Type: research
