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Ceftriaxone-Resistant Gonorrhea - China, 2022
MMWR Morb Mortal Wkly Rep. 2024 Mar 28;73(12):255-259. doi: 10.15585/mmwr.mm7312a2.ABSTRACTGonorrhea is a widespread sexually transmitted infection; in 2022, China reported 96,313 cases of gonorrhea, making it the fourth most common notifiable infectious disease in the country after viral hepatitis, pulmonary tuberculosis, and syphilis. The rise in prevalence in antimicrobial-resistant strains, particularly the international spread of ceftriaxone-resistant clones, poses a formidable challenge to gonorrhea control. The China Gonococcal Resistance Surveillance Program (China-GRSP), established in 1987 and covering 19 of 34 p...
Source: MMWR Morb Mortal Wkl... - March 28, 2024 Category: Epidemiology Authors: Xiaoyu Zhu Yue Xi Xiangdong Gong Shaochun Chen Source Type: research

Copper perchlorate catalyzed oxidative cyclisation of a novel bishydrazone ligand, formation of an unusual copper complex and in vitro biological implications
J Inorg Biochem. 2024 Mar 22;255:112538. doi: 10.1016/j.jinorgbio.2024.112538. Online ahead of print.ABSTRACTA novel hexadentate bishydrazone ligand, 1,10-bis(di(2-pyridyl)ketone) adipic acid dihydrazone (H2L1) is synthesized and characterized. With copper perchlorate as a catalytic oxidant, the ligand undergoes oxidative cyclisation and resulted in the formation of an unusual copper complex [Cu(L1a)2Cl]ClO4 (1), where L1a is 3-(2-pyridyl)triazolo[1,5-a]-pyridine. The Cu(II) complex was characterized physicochemically, while the molecular structure was confirmed by single crystal X- ray diffraction. In the complex cation, ...
Source: Journal of Inorganic Biochemistry - March 28, 2024 Category: Biochemistry Authors: Lakshmi V Menon E Manoj Source Type: research

Expression of Concern: Sunlit expeditious visible light-mediated photo-Fenton degradation of Ciprofloxacin by exfoliation of NiCo 2 O 4 and Zn 0.3 Fe 2.7 O 4 over g-C 3 N 4 matrix: A brief insight on degradation mechanism, degraded product toxicity, and genotoxic evaluation in Allium cepa (Chemosphere, Volume 303, Part 1, September 2022, 134963)
Chemosphere. 2024 Apr;353:141612. doi: 10.1016/j.chemosphere.2024.141612. Epub 2024 Mar 2.NO ABSTRACTPMID:38528405 | DOI:10.1016/j.chemosphere.2024.141612 (Source: Chemosphere)
Source: Chemosphere - March 26, 2024 Category: Chemistry Source Type: research

Expression of Concern: Sunlit expeditious visible light-mediated photo-Fenton degradation of Ciprofloxacin by exfoliation of NiCo(2)O(4) and Zn(0.3)Fe(2.7)O(4) over g-C(3)N(4) matrix: A brief insight on degradation mechanism, degraded product toxicity, and genotoxic evaluation in Allium cepa (Chemosphere, Volume 303, Part 1, September 2022, 134963)
Chemosphere. 2024 Apr;353:141612. doi: 10.1016/j.chemosphere.2024.141612. Epub 2024 Mar 2.NO ABSTRACTPMID:38528405 | DOI:10.1016/j.chemosphere.2024.141612 (Source: Chemosphere)
Source: Chemosphere - March 26, 2024 Category: Chemistry Source Type: research

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated
The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair. Here, we have employed a multi-omics approach to elucidate the temporal coordination of the SOS response. Escherichia coli was grown in batch cultivation in bioreactors to ensure highly controlled conditions, and a low dose of the antibiotic ciprofloxacin was used to activate the SOS response while avoiding extensive cell death. Our results show that expression of genes involved in error-free and error-prone repair were bo...
Source: Frontiers in Microbiology - March 26, 2024 Category: Microbiology Source Type: research

Sensors, Vol. 24, Pages 2126: Efficient Sequential Detection of Two Antibiotics Using a Fiber-Optic Surface Plasmon Resonance Sensor
Huang Su Antibiotic residues have become a worldwide public safety issue. It is vital to detect multiple antibiotics simultaneously using sensors. A new and efficient method is proposed for the combined detection of two antibiotics (enrofloxacin (Enro) and ciprofloxacin (Cip)) in milk using surface plasmon resonance (SPR) sensors. Based on the principle of immunosuppression, two antibiotic antigens (for Enro and Cip) were immobilized on an optical fiber surface with conjugates of bovine serum albumin using dopamine (DA) polymerization. Each single antigen was bound to its corresponding antibody to derive standard c...
Source: Sensors - March 26, 2024 Category: Biotechnology Authors: Zhao Yin Xiao Cui Huang Su Tags: Article Source Type: research

Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - March 26, 2024 Category: Nanotechnology Authors: Hussan Sobia Nisa Syeda Asma Bano Muhammad Zia Source Type: research

Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - March 26, 2024 Category: Nanotechnology Authors: Hussan Sobia Nisa Syeda Asma Bano Muhammad Zia Source Type: research

Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin
This study illustrates the role of quorum sensing-mediated phenotypic resistance and suggests a strategy for its prevention.PMID:38526048 | DOI:10.1128/aac.00118-24 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - March 25, 2024 Category: Microbiology Authors: Lexin Xia Yue Li Yufan Wang Hui Zhou Ajai A Dandekar Feng Xu Meizhen Wang Source Type: research