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Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - March 26, 2024 Category: Nanotechnology Authors: Hussan Sobia Nisa Syeda Asma Bano Muhammad Zia Source Type: research

Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin
This study illustrates the role of quorum sensing-mediated phenotypic resistance and suggests a strategy for its prevention.PMID:38526048 | DOI:10.1128/aac.00118-24 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - March 25, 2024 Category: Microbiology Authors: Lexin Xia Yue Li Yufan Wang Hui Zhou Ajai A Dandekar Feng Xu Meizhen Wang Source Type: research

Stenotrophomonas maltophilia neonatal sepsis: a case report
ConclusionsThis report describes a neonatal sepsis case caused byS. maltophilia, a multi-drug resistant bacteria and a rare cause of neonatal sepsis. We report that early detection of the bacterial and antimicrobial management based on local antibiogram data may be essential for successful patient ’s management. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 25, 2024 Category: General Medicine Source Type: research

Mechanistic study of the electrochemical oxidation of fluoroquinolones: Ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin
Chemosphere. 2024 Mar 22:141763. doi: 10.1016/j.chemosphere.2024.141763. Online ahead of print.ABSTRACTThe fluoroquinolones ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin, occur in water bodies worldwide and therefore pose a threat to the aquatic environment. Advanced purification procedures, such as electrochemical oxidation, may act as a remedy since they contribute to eliminating contaminants and prevent micropollutants from entering open water bodies. By electrochemical treatment in a micro-flow reactor equipped with a boron-doped diamond (BDD) electrode, the fluoroquinolones were efficiently degr...
Source: Chemosphere - March 24, 2024 Category: Chemistry Authors: Melanie Voigt Jean-Michel Dluziak Nils Wellen Martin Jaeger Source Type: research

2,3-Dichloronaphthoquinone derivatives: Synthesis, antimicrobial activity, molecular modelling and ADMET studies
Bioorg Chem. 2024 Mar 20;146:107300. doi: 10.1016/j.bioorg.2024.107300. Online ahead of print.ABSTRACTIn the present study, an intermediate namely 2-(3-bromopropylamino)-3-chloronaphthalene-1,4-dione was initially synthesized via the nucleophilic addition-elimination reaction between 2,3-dichloro-1,4-naphthoquinone and 3-bromo-1-aminopropane. Then a coupling reaction between the intermediate and piperazine derivatives yielded a number of 1,4-naphthoquinone derivatives. Spectroscopic analysis successfully characterized the products that were obtained in good yields. In vitro antibacterial properties of the compounds were ex...
Source: Bioorganic Chemistry - March 24, 2024 Category: Chemistry Authors: Hakan Kolanc ılar Hafize Özcan Ay şen Şuekinci Yılmaz Alparslan Semih Salan Abdulilah Ece Source Type: research

Ultrasonic-assisted synthesis of CaCu 3 Ti 4 O 12 /reduced graphene oxide composites for enhanced photocatalytic degradation of pharmaceutical products: Ibuprofen and Ciprofloxacin
The objective of this research is to create a highly effective approach for eliminating pollutants from the environment through the process of photocatalytic degradation. The study centers around the production of composites consisting of CaCu3Ti4O12 (CCTO) and reduced graphene oxide (rGO) using an ultrasonic-assisted method, with a focus on their capacity to degrade ibuprofen (IBF) and ciprofloxacin (CIP) via photodegradation. The impact of rGO on the structure, morphology, and optical properties of CCTO was inspected using XRD, FTIR, Raman, FESEM, XPS, BET, and UV-Vis. Morphology characterization showed that rGO particle...
Source: Environmental Science and Pollution Research International - March 22, 2024 Category: Environmental Health Authors: Mohsen Ahmadipour Mohammad Rezaei Ardani Mohsen Sarafbidabad Nadhem Missaoui Meenaloshini Satgunam Ramesh Singh Hamza Kahri Ujjwal Pal Ai Ling Pang Muhammad Saqlain Iqbal Renuka Garg Anish Bhattacharya Source Type: research

Prevalence of antibiotics, antibiotic resistance genes, and their associations in municipal wastewater treatment plants along the Yangtze River basin, China
Environ Pollut. 2024 Mar 20:123800. doi: 10.1016/j.envpol.2024.123800. Online ahead of print.ABSTRACTThe overuse and misuse of antibiotics have resulted in the pollution of antibiotics and antibiotic resistance genes (ARGs) in municipal wastewater treatment plants (WWTPs), posing threats to ecological security and human health. Thus, a comprehensive investigation was conducted to assess the occurrence, removal efficiency, and ecological risks of antibiotics, along with the diversity, abundance, and co-occurrence of ARGs, and their correlations in 13 WWTPs along the Yangtze River Basin. Among 35 target antibiotics, 23 antib...
Source: Environmental Pollution - March 22, 2024 Category: Environmental Health Authors: Yangyang Zhang Yifan Hu Xiuwen Li Linjun Gao Shuya Wang Shuyu Jia Peng Shi Aimin Li Source Type: research

In vitro and in silico studies of enterobactin-inspired Ciprofloxacin and Fosfomycin first generation conjugates on the antibiotic resistant E. coli OQ866153
The emergence of antimicrobial resistance in bacterial pathogens is a growing concern worldwide due to its impact on the treatment of bacterial infections. The "Trojan Horse" strategy has been proposed as a po... (Source: BMC Microbiology)
Source: BMC Microbiology - March 22, 2024 Category: Microbiology Authors: Mohamed T. Khazaal, Ahmed H. I. Faraag and Hoda H. El-Hendawy Tags: Research Source Type: research